INT95507

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Context Info
Confidence 0.33
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.49
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
body 2
Ghr (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 20 99.22 Very High Very High Very High
opiate 1 98.22 Very High Very High Very High
Morphine 3 90.88 High High
Hippocampus 3 84.12 Quite High
Spinal cord 3 78.64 Quite High
cytokine 15 77.00 Quite High
Somatostatin 44 59.36 Quite High
Inflammatory response 3 30.40 Quite Low
Dopamine 18 5.00 Very Low Very Low Very Low
agonist 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Htlv Types I And Ii 2 99.58 Very High Very High Very High
Body Weight 8 98.56 Very High Very High Very High
Adenoma 20 54.20 Quite High
Cancer 25 52.96 Quite High
Acromegaly 54 50.00 Quite Low
Disease 17 43.40 Quite Low
INFLAMMATION 7 30.40 Quite Low
Atherosclerosis 11 24.80 Low Low
Obesity 8 5.00 Very Low Very Low Very Low
Pituitary Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, the recently developed antisense oligonucleotide, ATL 227446, effectively inhibited hepatic GH receptor expression and IGF-I production and decreased body weight gain in mice (Tachas et al 2006).
Negative_regulation (inhibited) of Gene_expression (expression) of GH receptor in body associated with body weight and htlv types i and ii
1) Confidence 0.33 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.20 Pain Relevance 0.15
Theoretically, this could be accomplished by the construction of GH receptor antagonists and by RNA antisense techniques, thus preventing the synthesis of the GH receptor.
Negative_regulation (preventing) of Gene_expression (synthesis) of GH receptor associated with antagonist
2) Confidence 0.33 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676637 Disease Relevance 0.29 Pain Relevance 0.16
This result indicates that the opiate does not only affect the receptor protein as shown earlier by binding studies, but also reduces the expression or turnover of the GHR as well as GHBP at the transcription level.
Negative_regulation (reduces) of Gene_expression (expression) of GHBP associated with opiate
3) Confidence 0.15 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.56
-mediated downregulation of murine growth hormone receptor expression has been shown to be due to inhibition of Sp1 and Sp3 binding [30].
Negative_regulation (downregulation) of Gene_expression (expression) of growth hormone receptor
4) Confidence 0.06 Published 2008 Journal Cell Signal Section Body Doc Link PMC2586094 Disease Relevance 0 Pain Relevance 0.04

General Comments

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