INT95511

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Context Info
Confidence 0.43
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Ghr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 6 98.88 Very High Very High Very High
opiate 2 98.22 Very High Very High Very High
Hippocampus 6 97.16 Very High Very High Very High
Spinal cord 6 91.68 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result indicates that the opiate does not only affect the receptor protein as shown earlier by binding studies, but also reduces the expression or turnover of the GHR as well as GHBP at the transcription level.
Negative_regulation (reduces) of Transcription (transcription) of GHR associated with opiate
1) Confidence 0.43 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.56
Northern blot analysis showed that in both tissues the levels of the transcripts for both GHR and GHBP were significantly decreased 4 h after a single dose of morphine.
Negative_regulation (decreased) of Transcription (transcripts) of GHR associated with morphine
2) Confidence 0.43 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.60

General Comments

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