INT95512

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Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 3.10
Pain Relevance 4.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
uterine 3
uterus 2
spinal cord 2
liver 1
brain stem 1
Ghr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 312 100.00 Very High Very High Very High
Pain 6 100.00 Very High Very High Very High
Morphine 12 99.74 Very High Very High Very High
Spinal cord 20 99.08 Very High Very High Very High
Hippocampus 12 97.84 Very High Very High Very High
opiate 4 97.38 Very High Very High Very High
antagonist 44 87.60 High High
agonist 44 87.00 High High
Locus ceruleus 2 86.48 High High
parabrachial 2 80.32 Quite High
Disease Link Frequency Relevance Heat
Sepsis 222 99.56 Very High Very High Very High
Acid Base Imbalance 68 97.68 Very High Very High Very High
Uremia 2 95.76 Very High Very High Very High
Hyperplasia 11 92.24 High High
Endometrial Cancer 88 89.52 High High
Infection 12 87.84 High High
Acidosis 12 84.68 Quite High
Starvation 30 76.64 Quite High
Delayed Puberty 11 76.32 Quite High
Targeted Disruption 22 71.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Northern blot analysis showed that in both tissues the levels of the transcripts for both GHR and GHBP were significantly decreased 4 h after a single dose of morphine.
Transcription (transcripts) of GHR associated with morphine
1) Confidence 0.69 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.59
We failed to demonstrate significant differences between septic and sham-operated animals in expression of mRNA of the GHR or IGF-I, nutritional differences appearing to be of more importance.
Transcription (expression) of GHR
2) Confidence 0.57 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.38 Pain Relevance 0.03
The mRNA expression of SOCS2, SOCS3, CIS, IGF-1 and GHR was defined as the mean normalized gene expression (MNE) difference in target gene expression relative to the 'housekeeping gene' 18S rRNA using the following equation [18]: MNE = [(Eref)CTref,mean]/[(Etarget)CTtarget,mean].


Transcription (expression) of GHR
3) Confidence 0.57 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0 Pain Relevance 0.03
Distribution of growth hormone receptor mRNA in the brain stem and spinal cord of the rat.
Transcription (Distribution) of growth hormone receptor mRNA in brain stem associated with pain and spinal cord
4) Confidence 0.56 Published 2005 Journal Neuroscience Section Title Doc Link 15664698 Disease Relevance 0 Pain Relevance 0.54
In this study we have characterized the nucleotide sequence of the cDNA for the growth hormone receptor (GHR) and examined the effects of morphine on the gene transcripts for GHR as well as GH binding protein (GHBP) in the male rat hippocampus and spinal cord.
Transcription (transcripts) of GHR in spinal cord associated with hippocampus, spinal cord and morphine
5) Confidence 0.53 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.48
This result indicates that the opiate does not only affect the receptor protein as shown earlier by binding studies, but also reduces the expression or turnover of the GHR as well as GHBP at the transcription level.
Transcription (transcription) of GHR associated with opiate
6) Confidence 0.53 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.55
Nutrition increased the expression of mRNA of both IGF-I and the GHR, while these were not affected by sepsis.
Transcription (expression) of GHR associated with sepsis
7) Confidence 0.52 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.48 Pain Relevance 0.09
The liver was stored at -70°C for subsequent analysis for the expression of mRNA of CIS, SOCS-2, SOCS-3, IGF-I and the GHR.


Transcription (expression) of GHR in liver
8) Confidence 0.52 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0 Pain Relevance 0.21
In established sepsis, nutrition and the route of administration of nutrition influences the circulating cytokine patterns and expression of mRNA of SOCS proteins, GHR and IGF-I.
Transcription (expression) of GHR associated with sepsis and cytokine
9) Confidence 0.44 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2206515 Disease Relevance 0.15 Pain Relevance 0.19
Parenteral versus enteral nutrition: effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis

Introduction

Transcription (expression) of growth hormone receptor associated with sepsis and cytokine
10) Confidence 0.44 Published 2007 Journal Crit Care Section Title Doc Link PMC2206515 Disease Relevance 0.35 Pain Relevance 0.20
In a study on bovines, GH-receptor mRNA was only found in the pregnant uterus, not in the non-pregnant [29], while in an immunohistochemistry study on the non-pregnant rat the GH receptor was found in the uterus (e.g. in luminal and glandular epithelium, and vascular endothelium) [14].
Neg (not) Transcription (found) of GH-receptor in uterus
11) Confidence 0.27 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
In the ICI treated animals no GH-receptor mRNA could be detected (Fig. 1).
Transcription (detected) of GH-receptor
12) Confidence 0.27 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
The wet weight of the uteri showed a similar pattern as induction of LE height and the GH-receptor mRNA levels, implicating that GH is involved in the regulation of uterine weight.
Transcription (levels) of GH-receptor in uterine
13) Confidence 0.27 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.34 Pain Relevance 0
Thus, when stated in the following text that the GH receptor mRNA was measured, it means in fact a combination of the mRNAs for the GH receptor and the GH binding protein was assessed.
Transcription (measured) of GH receptor
14) Confidence 0.26 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
In one study GH receptor mRNA was found in the mouse uterus, and the stromal expression decreased after progesterone treatment but E2 had no regulatory effect [28].
Transcription (found) of GH receptor in uterus
15) Confidence 0.24 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
The uterine wet weight, the LE height and the GH-receptor mRNA levels showed similar patterns, indicating that GH is involved in the regulation of uterine weight.
Transcription (levels) of GH-receptor in uterine
16) Confidence 0.20 Published 2003 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC156658 Disease Relevance 0.09 Pain Relevance 0
In sheep the GH receptor mRNA was found both in endometrium of cycling and pregnant animals [30].
Transcription (found) of GH receptor in endometrium
17) Confidence 0.20 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
The GH-receptor mRNA level was increased in the uteri of the animals that were treated with E2 as compared to the ICI group (Fig. 1).
Transcription (level) of GH-receptor
18) Confidence 0.20 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0
In this study we examined the effects of these compounds on the mRNA levels of the GH receptor/GH binding protein, IGF-I, ER?
Transcription (levels) of GH receptor
19) Confidence 0.20 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0.20 Pain Relevance 0.16
However, the animals treated with the pure antiestrogen ICI had levels of GH receptor mRNA below detection limit.
Transcription (levels) of GH receptor
20) Confidence 0.20 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC156658 Disease Relevance 0 Pain Relevance 0

General Comments

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