INT95514

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.30
Pain Relevance 0.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ghr) extracellular space (Ghr) extracellular region (Ghr)
plasma membrane (Ghr) nucleus (Ghr) cytoplasm (Ghr)
Anatomy Link Frequency
thyroid 1
Ghr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 3 98.88 Very High Very High Very High
Hippocampus 3 96.32 Very High Very High Very High
Spinal cord 9 90.84 High High
Inflammation 49 90.48 High High
cytokine 60 90.44 High High
opiate 1 86.48 High High
Inflammatory response 4 81.20 Quite High
fibrosis 5 77.12 Quite High
anesthesia 4 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinal Cord Injury 62 100.00 Very High Very High Very High
Sepsis 38 99.76 Very High Very High Very High
Apoptosis 2 90.72 High High
INFLAMMATION 54 90.48 High High
Death 2 89.20 High High
Fibrosis 5 77.12 Quite High
Immune System Diseases 1 75.28 Quite High
Renal Disease 2 63.96 Quite High
Malignant Neoplastic Disease 1 49.76 Quite Low
Pathologic Processes 1 47.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Yumet and colleagues [13] have recently shown in rats with abdominal sepsis that total GHR numbers are unchanged, with the impaired IGF-I response to GH being temporally related to a defect in STAT5 activation and increased SOCS mRNA expression.
Negative_regulation (numbers) of GHR associated with sepsis
1) Confidence 0.36 Published 2007 Journal Crit Care Section Body Doc Link PMC2206515 Disease Relevance 0.44 Pain Relevance 0.10
Northern blot analysis showed that in both tissues the levels of the transcripts for both GHR and GHBP were significantly decreased 4 h after a single dose of morphine.
Negative_regulation (decreased) of GHR associated with morphine
2) Confidence 0.19 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11335057 Disease Relevance 0 Pain Relevance 0.59
THRB (thyroid hormone receptor beta) is down-regulated at day 3 and 7 post-SCI, and GHR (growth hormone receptor) at day 7 (Figure 1b) and 25.
Negative_regulation (regulated) of growth hormone receptor in thyroid associated with spinal cord injury
3) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.86 Pain Relevance 0.30

General Comments

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