INT9552

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2011
Negated 12
Speculated 16
Reported most in Abstract
Documents 209
Total Number 225
Disease Relevance 128.67
Pain Relevance 19.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TNNI3) cytoplasm (TNNI3)
Anatomy Link Frequency
chest 22
heart 5
plasma 4
skeletal muscle 3
myocyte 3
TNNI3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 564 99.96 Very High Very High Very High
cva 171 99.90 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 25 99.52 Very High Very High Very High
Inflammation 372 99.28 Very High Very High Very High
Inflammatory response 142 98.96 Very High Very High Very High
Ultiva 13 98.80 Very High Very High Very High
Inflammatory marker 43 98.32 Very High Very High Very High
anesthesia 42 97.28 Very High Very High Very High
ischemia 217 95.48 Very High Very High Very High
cocaine 12 94.72 High High
Disease Link Frequency Relevance Heat
Injury 1401 100.00 Very High Very High Very High
Acute Coronary Syndrome 705 100.00 Very High Very High Very High
Renal Failure 66 100.00 Very High Very High Very High
Muscle Disease 37 100.00 Very High Very High Very High
Angina 409 99.96 Very High Very High Very High
Chronic Renal Insufficiency 25 99.96 Very High Very High Very High
Acute Renal Failure 3 99.96 Very High Very High Very High
Myocardial Infarction 832 99.92 Very High Very High Very High
Arrhythmias 2 Under Development 29 99.92 Very High Very High Very High
Pyometra 1740 99.90 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with acute myocardial infarction or angina pectoris, the cardiac troponin I mRNA levels were not increased over background levels.
Neg (not) Positive_regulation (increased) of cardiac troponin I mRNA associated with angina and myocardial infarction
1) Confidence 0.70 Published 2000 Journal Int. J. Clin. Lab. Res. Section Abstract Doc Link 10984126 Disease Relevance 0.34 Pain Relevance 0.10
Patients with elevated cTnI had a significantly higher APACHE II score (p < 0.001), required longer duration of mechanical ventilation (p = 0.004) and their mortality rate increased from 9.7% to 42.9% (OR 7.0, 95%CI 2.68–18.3, p < 0.001).
Positive_regulation (elevated) of cTnI
2) Confidence 0.70 Published 2005 Journal Crit Care Section Body Doc Link PMC1269455 Disease Relevance 0.62 Pain Relevance 0
Cardiac-specific troponin I (cTnI) was elevated.
Positive_regulation (elevated) of cTnI
3) Confidence 0.69 Published 2006 Journal Cardiovasc Intervent Radiol Section Abstract Doc Link 16604408 Disease Relevance 0.80 Pain Relevance 0.14
CONCLUSION: In patients with non-ST segment elevation ACS, first-pass myocardial PD in contrast-enhanced MDCT correlate closely with the presence of myocardial necrosis, as determined by increases in cTnI levels.


Spec (determined) Positive_regulation (increases) of cTnI
4) Confidence 0.69 Published 2010 Journal Eur Radiol Section Body Doc Link 20155270 Disease Relevance 0.06 Pain Relevance 0
Elevated cardiac troponin I (cTnI) is frequently observed in patients with severe sepsis and septic shock.
Positive_regulation (Elevated) of cardiac troponin I associated with sepsis
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2815772 Disease Relevance 1.00 Pain Relevance 0.04
Elevated cardiac troponin I (cTnI) is frequently observed in patients with severe sepsis and septic shock.
Positive_regulation (Elevated) of cTnI associated with sepsis
6) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2815772 Disease Relevance 1.01 Pain Relevance 0.04
Angina was diagnosed in the presence of significant coronary lesions found on CAG or MDCT or with positive test results on the treadmill test or SPECT in the absence of elevated cTn-I.
Positive_regulation (elevated) of cTn-I associated with angina
7) Confidence 0.67 Published 2011 Journal Journal of Korean Medical Science Section Body Doc Link PMC3012849 Disease Relevance 0.52 Pain Relevance 0.10
The concept of risk stratification for coronary intervention has evolved from lesion-based categorization to include clinical factors, for example, elevated levels of cardiac troponin.
Positive_regulation (levels) of cardiac troponin
8) Confidence 0.67 Published 2009 Journal Curr. Opin. Cardiol. Section Body Doc Link 19077819 Disease Relevance 0.15 Pain Relevance 0
It would seem, therefore, that PAPP-A is associated with inflammation and might be used to detect plaque instability and rupture before an increase in cardiac troponin T is detectable.
Positive_regulation (increase) of cardiac troponin T in plaque associated with inflammation and rupture
9) Confidence 0.67 Published 2010 Journal J. Int. Med. Res. Section Abstract Doc Link 20515576 Disease Relevance 1.95 Pain Relevance 0.95
Obese and very obese patients were younger and had a higher incidence of hypertension, diabetes mellitus, elevated cardiac troponin T, and C-reactive protein levels.
Positive_regulation (elevated) of cardiac troponin T
10) Confidence 0.67 Published 2007 Journal Eur. Heart J. Section Body Doc Link 17576661 Disease Relevance 0.07 Pain Relevance 0
BACKGROUND: Increased C-reactive protein (CRP) is an important prognostic indicator for early risk stratification in patients with an acute coronary syndrome (ACS), independent of, and in combination with, increased cardiac troponin T (cTnT).
Neg (independent) Positive_regulation (increased) of cardiac troponin T associated with acute coronary syndrome
11) Confidence 0.67 Published 2000 Journal Clin. Chem. Section Abstract Doc Link 11017937 Disease Relevance 0.17 Pain Relevance 0.07
In patients with acute myocardial infarction (n = 32), serum cardiac troponin-I was elevated within 4 to 6 hours, reached a mean peak level of 112 ng/ml (range 20 to 550 ng/ml) at 18 hours, and remained above normal for up to 6 to 8 days following infarction.
Positive_regulation (elevated) of cardiac troponin-I associated with infarction and myocardial infarction
12) Confidence 0.67 Published 1987 Journal Am. Heart J. Section Abstract Doc Link 3591601 Disease Relevance 0.38 Pain Relevance 0.05
In subjects (n = 34) with skeletal muscle damage (total CK = 338 to 5384 IU/L), cardiac troponin-I levels were not elevated above normal, although CK-MB isoenzyme was elevated in some patients.
Neg (not) Positive_regulation (elevated) of cardiac troponin-I in skeletal muscle
13) Confidence 0.67 Published 1987 Journal Am. Heart J. Section Abstract Doc Link 3591601 Disease Relevance 0.42 Pain Relevance 0.08
The diagnosis of myocardial infarction (MI) is established in patients with chest pain and equivocal electrocardiogram changes by demonstrating a rise in blood levels of creatine kinase MB (CK-MB) and/or an increase in cardiac troponin I (cTnI) or cardiac troponin T (cTnT).
Positive_regulation (increase) of cTnI in chest associated with angina and myocardial infarction
14) Confidence 0.66 Published 2002 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 11848617 Disease Relevance 0.34 Pain Relevance 0.10
The diagnosis of myocardial infarction (MI) is established in patients with chest pain and equivocal electrocardiogram changes by demonstrating a rise in blood levels of creatine kinase MB (CK-MB) and/or an increase in cardiac troponin I (cTnI) or cardiac troponin T (cTnT).
Positive_regulation (increase) of cardiac troponin I in chest associated with angina and myocardial infarction
15) Confidence 0.66 Published 2002 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 11848617 Disease Relevance 0.34 Pain Relevance 0.10
The sera of patients with impaired renal function without any cardiac failure showed no increase in troponin T and troponin I values.
Neg (no) Positive_regulation (increase) of troponin I associated with myocardial infarction
16) Confidence 0.65 Published 1997 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 9368795 Disease Relevance 0.40 Pain Relevance 0.07
In dogs, increased plasma levels of cTnI have been demonstrated in cases of toxaemia, babesiosis, myocarditis, and pericardial effusion and other heart diseases [10,11,14-16].
Positive_regulation (increased) of cTnI in heart associated with pressure and volume under development, heart disease, babesiosis and coronary heart disease
17) Confidence 0.64 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.28 Pain Relevance 0.04
Since even slightly increased levels of cTnI indicate myocyte injury, the analysis adds diagnostic and prognostic value to other clinical examinations in identifying patients at risk of cardiac events.
Positive_regulation (increased) of cTnI in myocyte associated with injury
18) Confidence 0.64 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.25 Pain Relevance 0.13
The cTnI levels were not increased and because no post mortem examinations were performed in these cases, it is unclear whether these deaths were consequences of the pyometra.


Neg (not) Positive_regulation (increased) of cTnI associated with pyometra
19) Confidence 0.64 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 1.08 Pain Relevance 0
In the present study, 7 of the 58 dogs with pyometra had increased plasma levels of cTnI.
Positive_regulation (increased) of cTnI in plasma associated with pyometra
20) Confidence 0.64 Published 2007 Journal Acta Vet Scand Section Body Doc Link PMC1839102 Disease Relevance 0.46 Pain Relevance 0

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