INT95537

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Context Info
Confidence 0.68
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.20
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP2D6) small molecule metabolic process (CYP2D6) oxidoreductase activity (CYP2D6)
endoplasmic reticulum (CYP2D6)
Anatomy Link Frequency
brain 1
hearts 1
CYP2D6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 8 94.76 High High
Opioid 2 93.16 High High
Hippocampus 4 74.88 Quite High
Thalamus 2 72.72 Quite High
Substantia nigra 2 71.92 Quite High
Pyramidal cell 4 62.32 Quite High
Inflammation 2 56.00 Quite High
Dextromethorphan 30 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
fluoxetine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 2 86.88 High High
INFLAMMATION 2 56.00 Quite High
Fibrosis 1 54.24 Quite High
Apoptosis 1 43.20 Quite Low
Coronary Heart Disease 1 40.00 Quite Low
Cardiovascular Disease 3 11.92 Low Low
Myocardial Infarction 9 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Neurological Disease 2 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The sloping background of the spectra was subtracted using a baseline fitted to the experimental data with the Andor CCD camera software, while the fitting of the CYP2D6 spectrum at ?
Transcription (spectrum) of CYP2D6
1) Confidence 0.68 Published 2007 Journal J Biol Inorg Chem Section Body Doc Link PMC2099460 Disease Relevance 0 Pain Relevance 0
Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain.
Transcription (expression) of CYP2D6 in brain
2) Confidence 0.53 Published 2001 Journal Pharmacogenetics Section Title Doc Link 11337939 Disease Relevance 0 Pain Relevance 0.41
A combination of in-situ hybridization coupled with immunohistochemistry on adjacent sections allowed simultaneous detection of CYP2D6 mRNA and protein.
Transcription (detection) of CYP2D6
3) Confidence 0.53 Published 2001 Journal Pharmacogenetics Section Abstract Doc Link 11337939 Disease Relevance 0 Pain Relevance 0.41
When information is available, it is based on a small number (often <10) of explanted hearts from subjects with various conditions.[10], [11], [12], [13] For instance, Thum and Borlak report the presence of CYP1A1, CYP2B6, CYP2C8, CYP2C19, CYP2D6 and CYP4B1 mRNAs in seven explanted hearts.
Transcription (presence) of CYP2D6 in hearts
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.20 Pain Relevance 0.03

General Comments

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