INT95538

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Context Info
Confidence 0.81
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 5.69
Pain Relevance 4.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (CYP2D6) small molecule metabolic process (CYP2D6) oxidoreductase activity (CYP2D6)
endoplasmic reticulum (CYP2D6)
Anatomy Link Frequency
liver 3
pyramidal cells 1
brain 1
cortex 1
CYP2D6 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 60 99.98 Very High Very High Very High
Antiemetics 6 99.78 Very High Very High Very High
tricyclic antidepressant 35 99.60 Very High Very High Very High
sSRI 59 99.48 Very High Very High Very High
Analgesic 11 99.44 Very High Very High Very High
Nortriptyline 6 99.20 Very High Very High Very High
beta blocker 1 99.04 Very High Very High Very High
Substantia nigra 6 98.80 Very High Very High Very High
Endep 8 98.60 Very High Very High Very High
Pyramidal cell 6 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Vomiting 142 99.78 Very High Very High Very High
Disease 591 98.08 Very High Very High Very High
Glaucoma 2 94.16 High High
Attention Deficit Hyperactivity Disorder 52 93.60 High High
Hepatic Insufficiency 3 92.84 High High
Suicidal Behaviour 3 92.56 High High
Depression 96 91.12 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 89.68 High High
Autoimmune Hepatitis 68 87.92 High High
Breast Cancer 2 87.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, CYP2D6 protein was primarily localized in large principal neurons such as pyramidal cells of the cortex, pyramidal cells of the hippocampus, and Purkinje cells of the cerebellum.
Localization (localized) of CYP2D6 protein in pyramidal cells associated with pyramidal cell and hippocampus
1) Confidence 0.81 Published 2001 Journal Pharmacogenetics Section Abstract Doc Link 11337939 Disease Relevance 0 Pain Relevance 0.50
Timolol is mainly metabolized by cytochrome P450 2D6 (CYP2D6) in the liver.
Localization (metabolized) of CYP2D6 in liver
2) Confidence 0.75 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 19912165 Disease Relevance 0.09 Pain Relevance 0.14
Cellular localization and regional distribution of CYP2D6 mRNA and protein expression in human brain.
Localization (localization) of CYP2D6 in brain
3) Confidence 0.75 Published 2001 Journal Pharmacogenetics Section Title Doc Link 11337939 Disease Relevance 0 Pain Relevance 0.40
Dolasetron, ondansetron and tropisetron, all in part metabolized by CYP2D6, are less effective in UMs than in other patients.
Localization (metabolized) of CYP2D6
4) Confidence 0.75 Published 2009 Journal Clin Pharmacokinet Section Abstract Doc Link 19902987 Disease Relevance 0.57 Pain Relevance 0.31
In absence of reductase, immobilized CYP2D6 might receive electrons from a reducing agent present in solution or directly from the electrode, by applying a proper voltage.
Localization (immobilized) of CYP2D6
5) Confidence 0.74 Published 2007 Journal J Biol Inorg Chem Section Body Doc Link PMC2099460 Disease Relevance 0 Pain Relevance 0
It is metabolized by the cytochrome P450 enzymes CYP2D6 and CYP3A4 and may interact with drugs that inhibit these enzymes, such as cimetidine, ketoconazole, paroxetine, fluoxetine, and fluvoxamine.
Localization (metabolized) of CYP2D6 associated with fluoxetine
6) Confidence 0.73 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647161 Disease Relevance 0.11 Pain Relevance 0.18
Clinically well-established polymorphic CYPs (i.e., CYP2C9, CYP2C19, and CYP2D6) were involved in the metabolism of approximately half of those drugs, including (in particular) NSAIDs metabolized mainly by CYP2C9, proton-pump inhibitors metabolized by CYP2C19, and beta blockers and several antipsychotics and antidepressants metabolized by CYP2D6.
Localization (metabolized) of CYP2D6 associated with antidepressant, beta blocker and cinod
7) Confidence 0.71 Published 2008 Journal Anal Bioanal Chem Section Abstract Doc Link 18695978 Disease Relevance 0 Pain Relevance 0.20
Extensive metabolism, predominantly via CYP1A2, to a lesser extent via CYP2D6, and at a very low rate via CYP2C9,151,152 has been reported, but the metabolites have no significant activity.153 Duloxetine is a moderate CYP2D6 inhibitor and may inhibit its own metabolism154,155 as well as the metabolism of CYP2D6 substrates, such as desimipramine.90,195 The inhibition or induction of CYP1A2 is not clinically important, and coadministration of duloxetine with CYP1A2 substrates does not necessitate their dose adjustment.193 However, potent inhibitors of CYP2D6 and CYP1A2 may result in enhanced duloxetine concentrations and a need for dose adjustment.191,193
Localization (extent) of CYP2D6 associated with duloxetine
8) Confidence 0.71 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.11 Pain Relevance 0.59
Timolol is mainly metabolized by cytochrome P450 2D6 (CYP2D6) in the liver.
Localization (metabolized) of cytochrome P450 2D6 in liver
9) Confidence 0.66 Published 2010 Journal Basic Clin. Pharmacol. Toxicol. Section Abstract Doc Link 19912165 Disease Relevance 0.09 Pain Relevance 0.13
CYP2D6 inhibitors, such as paroxetine, are associated with changes in atomoxetine pharmacokinetics similar to those observed among poor CYP2D6 metabolizers.
Localization (metabolizers) of CYP2D6
10) Confidence 0.61 Published 2009 Journal Paediatr Drugs Section Abstract Doc Link 19445548 Disease Relevance 0.40 Pain Relevance 0
Therefore, interactions with medicines may be seen with diazepam, propranolol, phenytoin, S-mephenytoin, and tricyclic or some SSRI antidepressants (in poor metabolizers of CYP2D6), whereas decreased efficacy of added medicines may be seen with cyclosporine and birth control hormones (Cephalon 2004).
Localization (metabolizers) of CYP2D6 associated with antidepressant and ssri
11) Confidence 0.61 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654790 Disease Relevance 0.13 Pain Relevance 0.25
This pattern suggests positive selection for CYP2D6 (Ingelman-Sundberg 2005), an enzyme that metabolizes opiates and amphetamine-like compounds, together with other substrates.
Localization (selection) of CYP2D6 associated with opiate
12) Confidence 0.54 Published 2008 Journal Proceedings of the Royal Society B: Biological Sciences Section Body Doc Link PMC2367444 Disease Relevance 0 Pain Relevance 0.10
Iloperidone should therefore not be given to people with mild, moderate or severe hepatic impairment, especially if a CYP2D6 deficiency is suspected or drugs that inhibit CYP2D6 or induce or inhibit CYP3A are added to or subtracted from iloperidone.33
Localization (deficiency) of CYP2D6
13) Confidence 0.52 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846148 Disease Relevance 0.35 Pain Relevance 0
Thus, the clinician should consider decreasing the dosage of concomitant drugs that are metabolized by CYP2D6, such as TCAs (eg, nortriptyline, amitriptyline, imipramine); phenothiazines; and Type 1C antiarrhythmics (eg, propafenone, flecainide).
Localization (metabolized) of CYP2D6 associated with nortriptyline, endep and tricyclic antidepressant
14) Confidence 0.45 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004640 Disease Relevance 0.61 Pain Relevance 0.67
7 hours) is predominantly metabolized in the liver via the cytochrome P450 enzyme CYP2D6.
Localization (metabolized) of CYP2D6 in liver
15) Confidence 0.37 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697527 Disease Relevance 0.46 Pain Relevance 0.17
Of particular interest are the potential interactions of cholinesterase inhibitors with other drugs of current use in patients with AD, such as antidepressants, neuroleptics, antiarrhythmics, analgesics, and antiemetics which are metabolized by the cytochrome P450 CYP2D6 enzyme (Bernard et al 2006).
Localization (metabolized) of CYP2D6 enzyme associated with antidepressant, analgesic, disease and antiemetics
16) Confidence 0.35 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.41 Pain Relevance 0.20
Donepezil potentially may interact with drugs metabolized via CYP1A2-, CYP2D6-, and CYP3A4-related enzymes; however, formal pharmacokinetic studies have revealed no clinically meaningful interactions with memantine, risperidone, sertraline, carbidopa/levodopa, theophylline, furosemide, cimetidine, warfarin, and digoxin (Tiseo et al 1998a, b, c, d, e, f; Seltzer 2005).
Localization (metabolized) of CYP2D6
17) Confidence 0.35 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0 Pain Relevance 0.03
CYP2D6-related therapeutic response
Localization (response) of CYP2D6
18) Confidence 0.35 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654795 Disease Relevance 0.30 Pain Relevance 0.19
In contrast, CYP2D6 protein was primarily localized in large principal neurons such as pyramidal cells of the cortex, pyramidal cells of the hippocampus, and Purkinje cells of the cerebellum.
Localization (localized) of CYP2D6 protein in cortex associated with pyramidal cell and hippocampus
19) Confidence 0.27 Published 2001 Journal Pharmacogenetics Section Abstract Doc Link 11337939 Disease Relevance 0 Pain Relevance 0.50
CYP2D6 is only found in small amounts (<2%), but accounts for the metabolism of almost 30% of all drugs [37].
Localization (found) of CYP2D6
20) Confidence 0.27 Published 2010 Journal Hepatitis Research and Treatment Section Body Doc Link PMC3021850 Disease Relevance 0.95 Pain Relevance 0.07

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