INT95544

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Context Info
Confidence 0.59
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.60
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Itpr1) nuclear envelope (Itpr1) endoplasmic reticulum (Itpr1)
protein complex (Itpr1) transmembrane transport (Itpr1) cytoplasm (Itpr1)
Anatomy Link Frequency
neuronal 1
Itpr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 1 99.16 Very High Very High Very High
Neuronal nitric oxide synthase 1 96.12 Very High Very High Very High
antinociception 10 94.40 High High
Morphine 6 93.44 High High
Glutamate 1 90.76 High High
IPN 1 89.44 High High
Antinociceptive 2 88.72 High High
antagonist 1 85.16 High High
Pain 4 83.32 Quite High
Intracerebroventricular 2 80.32 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 1 99.16 Very High Very High Very High
Adhesions 1 98.40 Very High Very High Very High
Nociception 1 97.68 Very High Very High Very High
Targeted Disruption 8 93.04 High High
Neuropathic Pain 1 91.28 High High
Inflammatory Pain 1 89.44 High High
Fever 5 86.72 High High
Pain 3 83.32 Quite High
Cv General 2 Under Development 2 81.84 Quite High
Stroke 17 75.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A selective IP3R protein level reduction of approximately 30-50% produced by aODN administration for each receptor subtype investigated was demonstrated by Western blotting experiments.
Negative_regulation (reduction) of IP3R
1) Confidence 0.59 Published 2007 Journal Neuroscience Section Abstract Doc Link 17890015 Disease Relevance 0 Pain Relevance 0.31
In the present study, we confirmed that the IP3R1 mRNA in opisthonos (opt) heterozygote mice was approximately 50% reduced as compared to that in wild-type mice.
Negative_regulation (reduced) of IP3R1
2) Confidence 0.41 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12972155 Disease Relevance 0 Pain Relevance 1.00
Nociceptive responses to an intraperitoneal injection of acetic acid and hyperalgesia induced by carrageenan were abolished by IP-receptor deficiency.
Negative_regulation (deficiency) of IP-receptor associated with nociception and hyperalgesia
3) Confidence 0.19 Published 2001 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 11338373 Disease Relevance 1.08 Pain Relevance 0.35
These cAMP cascades can provide protection for example by: (1) reducing the release of endoplasmic Ca2+ through the inositol triphosphate receptor [23], (2) inhibiting the expression of adhesion molecules [24], (3) suppressing the activity of neuronal nitric oxide synthase [25], (4) stimulating cAMP response element binding (CREB) [26], and (5) stimulating the high-affinity glutamate transporter [27].
Negative_regulation (reducing) of inositol triphosphate receptor in neuronal associated with glutamate, adhesions and neuronal nitric oxide synthase
4) Confidence 0.08 Published 2010 Journal Exp Transl Stroke Med Section Body Doc Link PMC2912268 Disease Relevance 0.51 Pain Relevance 0.20

General Comments

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