INT95556

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Context Info
Confidence 0.58
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.10
Pain Relevance 3.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
nerve 2
striatum 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 59 100.00 Very High Very High Very High
agonist 35 100.00 Very High Very High Very High
Antihyperalgesic 2 99.26 Very High Very High Very High
Cancer pain 3 98.70 Very High Very High Very High
GABAergic 5 98.26 Very High Very High Very High
antagonist 15 98.04 Very High Very High Very High
tolerance 7 97.76 Very High Very High Very High
Inflammation 4 96.36 Very High Very High Very High
Hyperalgesia 10 95.56 Very High Very High Very High
Analgesic 3 86.48 High High
Disease Link Frequency Relevance Heat
Epilepsy 51 99.12 Very High Very High Very High
Cancer Pain 3 98.70 Very High Very High Very High
INFLAMMATION 4 96.36 Very High Very High Very High
Hyperalgesia 10 95.56 Very High Very High Very High
Sprains And Strains 5 94.00 High High
Vomiting 1 90.28 High High
Cancer 5 87.84 High High
Catalepsy 1 85.44 High High
Myalgia 2 75.00 Quite High
Status Epilepticus 37 72.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The loss of hilar mossy cells and GABAergic interneurons during the development of TLE in similar models [55] and the concomitant loss of CB1R associated with these nerve terminals could contribute to a reduction in the density of CB1R observed in immunohistochemical analyses.
Negative_regulation (loss) of CB1R Binding (associated) of in nerve associated with epilepsy and gabaergic
1) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2871782 Disease Relevance 0.58 Pain Relevance 0.37
The net CB1 receptor agonist (WIN55,212-2 or HU-210 or CP55,940)-stimulated [(35)S]GTPgammaS binding was reduced significantly (-10% to -12%, P < 0.05) in PM from DBA/2 mice; no significant differences were observed in basal [(35)S]GTPgammaS binding among these strains.
Negative_regulation (reduced) of CB1 receptor Binding (binding) of associated with cannabinoid, agonist and sprains and strains
2) Confidence 0.43 Published 2001 Journal J. Neurosci. Res. Section Abstract Doc Link 11340650 Disease Relevance 0.25 Pain Relevance 0.73
The cannabinoid 1 (CB1) receptors can be downregulated in vitro through an interaction with the G-protein-coupled receptor-associated sorting protein1, GASP1, that targets CB1 receptors for degradation after their agonist-mediated endocytosis.
Negative_regulation (downregulated) of CB1 Binding (interaction) of associated with cannabinoid and agonist
3) Confidence 0.41 Published 2010 Journal Neuropsychopharmacology Section Abstract Doc Link 20164830 Disease Relevance 0.29 Pain Relevance 0.77
Interestingly, TRPV1 binding was increased in the striatum of DAT KO mice, while CB1 receptor binding was unaffected.
Neg (unaffected) Negative_regulation (unaffected) of CB1 receptor Binding (binding) of in striatum
4) Confidence 0.39 Published 2006 Journal Biol. Psychiatry Section Body Doc Link 16199010 Disease Relevance 0.17 Pain Relevance 0
In the cancer pain model, the antihyperalgesic effect of WIN55,212-2 was partially blocked by pretreatment with the selective CB1 (SR141716A) but not the CB2 (SR144528) receptor antagonist.
Negative_regulation (blocked) of CB1 Binding (pretreatment) of associated with antihyperalgesic, cancer pain and antagonist
5) Confidence 0.33 Published 2003 Journal Pain Section Abstract Doc Link 12749972 Disease Relevance 1.82 Pain Relevance 1.80

General Comments

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