INT95565

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Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 47
Total Number 50
Disease Relevance 33.96
Pain Relevance 10.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
T cells 7
Th1 cell 2
fibroblasts 2
monocytes 2
Immune cells 2
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 802 100.00 Very High Very High Very High
Inflammation 503 100.00 Very High Very High Very High
psoriasis 139 99.44 Very High Very High Very High
rheumatoid arthritis 560 98.68 Very High Very High Very High
Inflammatory response 30 97.28 Very High Very High Very High
interstitial cystitis 3 97.16 Very High Very High Very High
monoamine 4 96.28 Very High Very High Very High
Arthritis 58 96.12 Very High Very High Very High
tricyclic antidepressant 1 95.16 Very High Very High Very High
Fibrositis 97 93.56 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 528 100.00 Very High Very High Very High
Infection 383 99.98 Very High Very High Very High
Cancer 553 99.96 Very High Very High Very High
Hepatitis C Virus Infection 423 99.78 Very High Very High Very High
Opiate Addiction 237 99.60 Very High Very High Very High
Coronary Artery Disease 30 99.60 Very High Very High Very High
Psoriasis 168 99.44 Very High Very High Very High
Bronchiectasis 70 99.36 Very High Very High Very High
Disease 362 99.24 Very High Very High Very High
Acne 11 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of these two HA preparations with deoxyribonuclease I abrogated or reduced the induction of IL-12 and TNF-alpha.
Positive_regulation (induction) of IL-12
1) Confidence 0.56 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.72 Pain Relevance 0.49
To assess whether co-administration of recombinant human IL-12 (rhIL-12) and 23-valent pneumococcal polysaccharide vaccine (PPV) enhances the antibody response to this T cell-independent antigen, healthy immunocompetent volunteers (n=34, 55-65 years old) were vaccinated intramusculary with PPV and concurrently-treated subcutaneously with either rhIL-12 (1 or 4 microg) or placebo.
Spec (whether) Positive_regulation (enhances) of rhIL-12 in T cell
2) Confidence 0.50 Published 2001 Journal Vaccine Section Abstract Doc Link 11567761 Disease Relevance 0 Pain Relevance 0
Primary dermal fibroblasts cultured from the patients were transduced with retroviral vector carrying human IL-12 genes (p35 and p40) as well as the neomycin phosphotransferase gene (TFG-hIL-12-Neo).
Positive_regulation (carrying) of p35 in fibroblasts
3) Confidence 0.50 Published 2001 Journal Hum. Gene Ther. Section Abstract Doc Link 11426466 Disease Relevance 0.34 Pain Relevance 0
Primary dermal fibroblasts cultured from the patients were transduced with retroviral vector carrying human IL-12 genes (p35 and p40) as well as the neomycin phosphotransferase gene (TFG-hIL-12-Neo).
Positive_regulation (carrying) of IL-12 in fibroblasts
4) Confidence 0.43 Published 2001 Journal Hum. Gene Ther. Section Abstract Doc Link 11426466 Disease Relevance 0.33 Pain Relevance 0
We unexpectedly found that the induction of IL-12 and TNF-alpha by these HA preparations was not due to their degradation to low-molecular-weight fragments, since their native high-molecular-weight forms possessed the same ability to stimulate IL-12 and TNF-alpha synthesis, but was due to the presence of contaminating DNA.
Positive_regulation (induction) of IL-12
5) Confidence 0.41 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.69 Pain Relevance 0.45
Low-molecular-weight fragments derived from HA have been reported to induce pro-inflammatory cytokines such as IL-12 and TNF-alpha, and could therefore potentially exacerbate existing inflammation.
Positive_regulation (induce) of IL-12 associated with inflammation and cytokine
6) Confidence 0.38 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.74 Pain Relevance 0.47
Additional data support the role of IL-12 and IL-23 in psoriasis, when genetic studies found associations between certain polymorphisms of the IL-12 receptor (IL-12R) and IL-23R genes and psoriasis.27 It is noteworthy that the sequences/processes depicted above portray a simplified version of what is rather a very complex and intricate model.
Positive_regulation (role) of IL-12 associated with psoriasis
7) Confidence 0.36 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.66 Pain Relevance 0.22
production in response to IL-12 and IL-18 when compared with H-PBMCs.
Positive_regulation (response) of IL-12
8) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400411 Disease Relevance 1.10 Pain Relevance 0.57
In order to assess overall differences in systemic response to the Th1-inducing cytokines, IL-12 and IL-18, we compared the IFN-?
Positive_regulation (inducing) of IL-12 associated with cytokine
9) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.66 Pain Relevance 0.42
in response to IL-12 and IL-18 than those of healthy volunteers.
Positive_regulation (response) of IL-12
10) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.50 Pain Relevance 0.33
Early studies suggested that the effects of IL-18 on Th1 differentiation were independent of IL-12.
Neg (independent) Positive_regulation (independent) of IL-12
11) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.38 Pain Relevance 0.31
However, later studies showed that exogenous IL-18 in the absence of IL-12 failed to drive the differentiation of naive T cells to Th1 cells [16] and that IL-18 was a potent inducer of IFN-?
Positive_regulation (absence) of IL-12 in Th1 cells
12) Confidence 0.33 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.34 Pain Relevance 0.27
To further explore the mechanisms involved in heroin use- or heroin use plus HCV infection-mediated impairment of CD56+ T cell function, we attempted to determine whether heroin use or heroin use plus HCV infection induce the expression of negative regulators in IL-12 signaling pathway.
Spec (whether) Positive_regulation (induce) of IL-12 in T cell associated with hepatitis c virus infection, opiate addiction and infection
13) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 1.28 Pain Relevance 0
The relative abundance of these elements in IL-12-stimulated CD56+ T cells were correlated to GAPDH mRNA and there was no difference in the expression patterns of these mRNAs between normal subjects, heroin users with HCV infection, and heroin users without HCV infection (P>0.05) (Fig. 6).
Positive_regulation (abundance) of IL-12-stimulated in T cells associated with hepatitis c virus infection, opiate addiction and infection
14) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.40 Pain Relevance 0.03
However, we also noted a significant elevation for IL-12 plasma levels for all groups compared to unrelated controls (Figure 2).
Positive_regulation (nt elevat) of IL-12 in plasma
15) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794536 Disease Relevance 1.04 Pain Relevance 0.51
When stimulated by IL-12, CD56+ T cells from HCV-infected heroin users produced significantly lower levels of IFN-?
Positive_regulation (stimulated) of IL-12 in T cells associated with opiate addiction and hepatitis c virus infection
16) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.24 Pain Relevance 0
Although there was significant upregulation of IL-12 and TNF in the responders of all the groups who were cured 6-months posttreatment compared to the untreated (P?
Positive_regulation (upregulation) of IL-12
17) Confidence 0.18 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2910702 Disease Relevance 0.42 Pain Relevance 0.11
These studies showed that stage I tumors displayed a significantly higher frequency of IL-12R?
Positive_regulation (frequency) of IL-12R associated with cancer
18) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 1.09 Pain Relevance 0.09
The IL-12 receptor (R) is comprised of two subunits, i.e. the ubiquitous IL-12R?
Positive_regulation (ubiquitous) of IL-12R
19) Confidence 0.16 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2702099 Disease Relevance 0.49 Pain Relevance 0.13
0.012) higher frequency of IL-12R?
Positive_regulation (frequency) of IL-12R
20) Confidence 0.16 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2702099 Disease Relevance 1.41 Pain Relevance 0

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