INT95566

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 7.47
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
T cells 6
dendritic cells 2
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 73 100.00 Very High Very High Very High
Inflammation 70 93.92 High High
chemokine 9 89.48 High High
interstitial cystitis 1 67.52 Quite High
withdrawal 3 66.72 Quite High
Arthritis 2 66.48 Quite High
headache 3 63.96 Quite High
dexamethasone 13 5.00 Very Low Very Low Very Low
Opioid 12 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis C Virus Infection 234 99.16 Very High Very High Very High
Opiate Addiction 158 98.64 Very High Very High Very High
Cancer 177 95.08 Very High Very High Very High
Infection 134 94.72 High High
INFLAMMATION 75 93.92 High High
Glioblastoma 21 89.60 High High
Glioma 117 74.96 Quite High
Granuloma 1 74.40 Quite High
Disease 35 73.28 Quite High
Recurrence 24 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We unexpectedly found that the induction of IL-12 and TNF-alpha by these HA preparations was not due to their degradation to low-molecular-weight fragments, since their native high-molecular-weight forms possessed the same ability to stimulate IL-12 and TNF-alpha synthesis, but was due to the presence of contaminating DNA.
Neg (not) Positive_regulation (due) of Positive_regulation (induction) of IL-12
1) Confidence 0.41 Published 2001 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 11341374 Disease Relevance 0.70 Pain Relevance 0.45
The relative abundance of these elements in IL-12-stimulated CD56+ T cells were correlated to GAPDH mRNA and there was no difference in the expression patterns of these mRNAs between normal subjects, heroin users with HCV infection, and heroin users without HCV infection (P>0.05) (Fig. 6).
Positive_regulation (correlated) of Positive_regulation (abundance) of IL-12-stimulated in T cells associated with hepatitis c virus infection, opiate addiction and infection
2) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.42 Pain Relevance 0.03
When stimulated by IL-12, CD56+ T cells from HCV-infected heroin users produced significantly lower levels of IFN-?
Positive_regulation (When) of Positive_regulation (stimulated) of IL-12 in T cells associated with opiate addiction and hepatitis c virus infection
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.24 Pain Relevance 0
Novel type-1 DCs were employed in UPCI 99-111, and these DCs generated from each participant demonstrated enhanced IL-12 p70 producing capability in vitro compared to standard DCs from the same donors.
Positive_regulation (enhanced) of Positive_regulation (capability) of IL-12
4) Confidence 0.15 Published 2007 Journal J Transl Med Section Body Doc Link PMC2254376 Disease Relevance 0.24 Pain Relevance 0.04
These results demonstrate that type-1 DCs capable of producing high levels of IL-12 were successfully generated in the current trial.


Positive_regulation (generated) of Positive_regulation (levels) of IL-12
5) Confidence 0.15 Published 2007 Journal J Transl Med Section Body Doc Link PMC2254376 Disease Relevance 0.27 Pain Relevance 0.06
On the vaccination day, a small aliquot of DCs (8 × 104) were tested for IL-12 production capability by specific ELISA.


Positive_regulation (tested) of Positive_regulation (capability) of IL-12
6) Confidence 0.15 Published 2007 Journal J Transl Med Section Body Doc Link PMC2254376 Disease Relevance 0.37 Pain Relevance 0.12
The biologically active IL-12 (IL-12p70) is a heterodimeric cytokine that consists of two heterologous chains, named p40 and p35.
Positive_regulation (named) of Positive_regulation (active) of IL-12p70 associated with cytokine
7) Confidence 0.09 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.34 Pain Relevance 0.24
The biologically active IL-12 (IL-12p70) is a heterodimeric cytokine that consists of two heterologous chains, named p40 and p35.
Positive_regulation (named) of Positive_regulation (active) of IL-12 associated with cytokine
8) Confidence 0.09 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2491649 Disease Relevance 0.34 Pain Relevance 0.24
This phenotype is characterized by high capacity to present antigens and high capacity to produce IL-12 (promoting Th1 responses) and IL-23 (promoting maturation and survival of IL-17 producing T cells), as well as microbicidal nitric oxide and reactive oxygen intermediates.
Positive_regulation (promoting) of Positive_regulation (promoting) of IL-12 in T cells
9) Confidence 0.08 Published 2010 Journal Respir Res Section Body Doc Link PMC2939603 Disease Relevance 0.49 Pain Relevance 0.21
Lectin-induced enhancement of IL-12 may indicate the selective activation of the Th1 pathway in dendritic cells derived from CD16?
Positive_regulation (Lectin-induced) of Positive_regulation (enhancement) of IL-12 in dendritic cells
10) Confidence 0.04 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062151 Disease Relevance 0.05 Pain Relevance 0.04

General Comments

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