INT95580

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Context Info
Confidence 0.21
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.51
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Afm) extracellular space (Afm) extracellular region (Afm)
Anatomy Link Frequency
blood 1
hepatocyte 1
Afm (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 35 100.00 Very High Very High Very High
cytokine 93 70.08 Quite High
Inflammation 16 69.68 Quite High
fibrosis 16 69.12 Quite High
Potency 2 36.48 Quite Low
alcohol 6 5.00 Very Low Very Low Very Low
Bile 6 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Liver Failure 64 100.00 Very High Very High Very High
Apoptosis 50 99.74 Very High Very High Very High
Death 7 97.96 Very High Very High Very High
Disease 38 93.84 High High
Poisoning 2 91.92 High High
Cerebral Edema 19 90.32 High High
Injury 14 90.00 High High
Pressure And Volume Under Development 94 89.84 High High
Targeted Disruption 29 89.76 High High
Hepatotoxicity 8 82.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The toxic metabolite, N-acetyl-p-benzoquinone-imine (NAPQI), that leads to gluthatione depletion has been suspected to be the main effector of hepatocyte apoptosis during APAP-induced ALF.
Positive_regulation (induced) of ALF in hepatocyte associated with paracetamol, acute liver failure and apoptosis
1) Confidence 0.21 Published 2001 Journal Hepatology Section Abstract Doc Link 11343246 Disease Relevance 0.81 Pain Relevance 0.66
We have investigated whether reactive oxygen species (ROS) also play a role in APAP-induced ALF, and whether manganese III tetrakis (5,10,15,20 benzoic acid) (MnTBAP), a mimic of superoxide dismutase (SOD) with catalase-like activity, can treat the disease in mice.
Positive_regulation (role) of ALF associated with paracetamol, acute liver failure and disease
2) Confidence 0.15 Published 2001 Journal Hepatology Section Abstract Doc Link 11343246 Disease Relevance 0.87 Pain Relevance 0.68
By contrast, using a rat model of ALF induced by the hepatotoxin thioacetamide, which displays a more protracted clinical course (death occurring at 72-80 h), we found a modest increase (32%) in IFN-?
Positive_regulation (induced) of ALF associated with acute liver failure and death
3) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964656 Disease Relevance 1.54 Pain Relevance 0.10
Among the single polymorphisms, the K8 R340H variant was found at significantly higher frequencies in the whole ALF cohort as well as in the acetaminophen-induced ALF subgroup (frequency 6.6 and 7.1%, respectively vs. 3.1% in the control group; P < 0.03 for both comparisons).
Positive_regulation (induced) of ALF associated with paracetamol and acute liver failure
4) Confidence 0.07 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.20 Pain Relevance 0.33
K8/K18 variants were significantly more frequent in total ALF patient cohort (46/345; 13.3%) and in patients with acetaminophen-induced ALF (21/169; 12.4%) when compared to blood bank donors (11/349; 3.7%; P < 0.002 for both comparisons).
Positive_regulation (induced) of ALF in blood associated with paracetamol and acute liver failure
5) Confidence 0.07 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 1.10 Pain Relevance 0.28

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