INT956

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Context Info
Confidence 0.59
First Reported 1975
Last Reported 2010
Negated 3
Speculated 1
Reported most in Abstract
Documents 94
Total Number 95
Disease Relevance 42.72
Pain Relevance 23.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (PRL) cytosol (PRL) extracellular region (PRL)
Anatomy Link Frequency
plasma 12
pituitary 3
thyroid 2
thyrotrophs 1
DA neurons 1
PRL (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 103 100.00 Very High Very High Very High
Opioid 46 100.00 Very High Very High Very High
Catecholamine 7 100.00 Very High Very High Very High
narcan 52 99.98 Very High Very High Very High
Sumatriptan 12 99.98 Very High Very High Very High
antagonist 335 99.96 Very High Very High Very High
Cluster headache 8 99.96 Very High Very High Very High
Dopamine 1153 99.80 Very High Very High Very High
Pain 48 99.78 Very High Very High Very High
agonist 505 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 403 99.96 Very High Very High Very High
Cluster Headache 8 99.96 Very High Very High Very High
Prolactinoma 147 99.84 Very High Very High Very High
Pain 28 99.78 Very High Very High Very High
Headache 47 99.76 Very High Very High Very High
Galactorrhea 2145 99.72 Very High Very High Very High
Hypoglycemia 6 99.70 Very High Very High Very High
Sleep Disorders 91 99.60 Very High Very High Very High
Congenital Anomalies 95 99.48 Very High Very High Very High
Adenoma 271 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is a highly significant decline in PRL levels during active labor which reaches a nadir about two hours prior to delivery.
Negative_regulation (decline) of PRL
1) Confidence 0.59 Published 1977 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 857677 Disease Relevance 0 Pain Relevance 0.10
PRL levels were significantly reduced +15, +30, and +60 min after the clonidine infusion.
Negative_regulation (reduced) of PRL associated with clonidine
2) Confidence 0.59 Published 1978 Journal Endocrinology Section Abstract Doc Link 217617 Disease Relevance 0 Pain Relevance 0.29
A 37-yr-old man with a 60-mm invasive tumor and a serum PRL level of 13,969 +/- 332 ng/ml (mean +/- SD) responded to BRC therapy with rapid disappearance of visual field defect, headache, and facial pain as well as decrease in serum PRL to 5,103 +/- 1,446 ng/ml.
Negative_regulation (decrease) of PRL associated with scotoma, pain, cancer and headache
3) Confidence 0.59 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3793856 Disease Relevance 1.00 Pain Relevance 0.39
Bromocriptine challenge induced a significant GH increase and a significant suppression of PRL.
Negative_regulation (suppression) of PRL
4) Confidence 0.59 Published 2000 Journal Psychoneuroendocrinology Section Abstract Doc Link 10818282 Disease Relevance 0 Pain Relevance 0.65
Tollin (Tollin 2000) reported 4 patients on risperidone, with significant hyperprolactinemia (65.5 to 209 ng/ml) that showed reduction of prolactin level and alleviated hypogonadism after dopamine agonists (bromocriptine or cabergoline) were added, without deterioration of psychotic symptoms.
Negative_regulation (reduction) of prolactin associated with reprotox - general 2, galactorrhea, dopamine, psychosis and agonist
5) Confidence 0.59 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 1.08 Pain Relevance 0.10
The neurobehavioral syndrome, that appears with the withdrawal of H2 receptors blockers and subsides with the restoration of the treatment or with the administration of a potent prolactin inducing drug as domperidone, should be related to a prompt reduction of prolactin levels (Rampello et al 1997).
Negative_regulation (reduction) of prolactin associated with syndrome, withdrawal and neurobehavioral
6) Confidence 0.59 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.34 Pain Relevance 0.49
Clonazepam (a central type benzodiazepine agonist) and diazepam (a mixed agonist) are reported to decrease prolactin levels, possibly through a direct action on the anterior pituitary gland (Jarvinen et al 1992) (Figure 2).
Negative_regulation (decrease) of prolactin in gland associated with agonist
7) Confidence 0.59 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.34 Pain Relevance 0.48
A significant decrease in prolactin levels has been reported in patients treated with flutamide alone (Akaza et al 1993) or with flutamide and an oral contraceptive formulation with ethinyl estradiol and cyproterone acetate (Taner et al 2002).
Negative_regulation (decrease) of prolactin
8) Confidence 0.59 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.28 Pain Relevance 0
Since the discontinuation of a neuroleptic therapy, or the addition of dopamine-agonists, may worsen the psychosis, and the reduction of the neuroleptic dose may not necessarily lead to decrease in prolactin, switching to prolactin sparing agents acquires great relevance.
Negative_regulation (decrease) of prolactin associated with dopamine, psychosis and agonist
9) Confidence 0.59 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376090 Disease Relevance 0.82 Pain Relevance 0.16
In women, a similar response was also observed but prolactin levels decreased earlier (30 min from the PGE2 infusion).
Negative_regulation (decreased) of prolactin
10) Confidence 0.59 Published 1992 Journal Eicosanoids Section Abstract Doc Link 1419076 Disease Relevance 0.08 Pain Relevance 0.25
Since the LOD and control group were in the same condition concerning the surgical and anesthesiologic stress, and the post-operation elevated PRL level was supposed to decrease after one week, the elevated PRL levels 6–10 weeks after operation in LOD group may be due to other cause than surgical or anesthesiologic stress.
Negative_regulation (decrease) of PRL associated with stress
11) Confidence 0.58 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1188073 Disease Relevance 0.71 Pain Relevance 0.15
A significative reduction of GH at 60' and of PRL at 30' was observed in both groups.
Negative_regulation (reduction) of PRL
12) Confidence 0.58 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0.18 Pain Relevance 0.13
In conclusion NLA and enflurane induced a decrease of GH and PRL plasma levels; in both groups the anaesthetic agents, at the dosage used during anaesthesia, blocked the response of these hormones to the surgical stress likely due to a block of the hypothalamic-pituitary response.
Negative_regulation (decrease) of PRL in plasma associated with stress
13) Confidence 0.58 Published 1985 Journal Minerva Med. Section Abstract Doc Link 4069417 Disease Relevance 0.26 Pain Relevance 0.07
Similarly, the inability of amphetamine or methylphenidate to decrease serum PRL levels in man suggests important differences between the tuberoinfundibular DA neurons in man and the rat.
Negative_regulation (decrease) of PRL in DA neurons
14) Confidence 0.58 Published 1982 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 6124090 Disease Relevance 0 Pain Relevance 0.34
One patient showed no increase in IR-LHRH or LH with BRCR therapy and failed to show a decrease in serum PRL to normal levels after five days of this treatment.
Negative_regulation (decrease) of PRL
15) Confidence 0.57 Published 1987 Journal J Reprod Med Section Abstract Doc Link 3550065 Disease Relevance 0.27 Pain Relevance 0.11
Three patients showed a significant rise in mean IR-LHRH plasma levels coincident with a significant decrease in mean PRL concentrations five days to two weeks following BRCR therapy, whereas mean LH titers increased significantly in only one patient.
Negative_regulation (decrease) of PRL in plasma
16) Confidence 0.57 Published 1987 Journal J Reprod Med Section Abstract Doc Link 3550065 Disease Relevance 0.30 Pain Relevance 0.12
The association of naloxone with insulin-induced hypoglycemia significantly reduced the PRL peak (p less than 0.05), did not affect the rise of GH and lowered the ACTH peak, without altering the LPH peak.
Negative_regulation (reduced) of PRL associated with hypoglycemia and narcan
17) Confidence 0.57 Published 1982 Journal Nouv Presse Med Section Abstract Doc Link 6280130 Disease Relevance 0.41 Pain Relevance 0.68
Diclofenac resulted in a significant and sustained decrease in plasma level of prolactin (p less than 0.005).
Negative_regulation (decrease) of prolactin in plasma associated with diclofenac
18) Confidence 0.57 Published 1988 Journal Horm. Res. Section Abstract Doc Link 2975630 Disease Relevance 0.08 Pain Relevance 0.30
Prl decreases were 11.7% and 24.8%, respectively.
Negative_regulation (decreases) of Prl
19) Confidence 0.57 Published 1984 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 6595321 Disease Relevance 0.18 Pain Relevance 0.18
Naloxone, a relatively specific narcotic antagonist, decreases serum prolactin and growth hormone levels in animals.
Negative_regulation (decreases) of prolactin associated with antagonist and narcan
20) Confidence 0.55 Published 1979 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 116298 Disease Relevance 0 Pain Relevance 0.28

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