INT95605

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Context Info
Confidence 0.44
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.20
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AGT) small molecule metabolic process (AGT) aging (AGT)
extracellular region (AGT) extracellular matrix organization (AGT) cell-cell signaling (AGT)
AGT (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 2 92.96 High High
bradykinin 3 78.64 Quite High
substance P 2 71.48 Quite High
medulla 1 54.24 Quite High
Catecholamine 1 53.24 Quite High
COX2 2 50.00 Quite Low
Bioavailability 6 28.40 Quite Low
Potency 3 23.76 Low Low
withdrawal 4 5.00 Very Low Very Low Very Low
cINOD 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 16 75.44 Quite High
Cough 2 74.84 Quite High
Cognitive Disorder 1 50.04 Quite High
Volume Depletion And Dehydration 1 50.00 Quite Low
Increased Venous Pressure Under Development 4 48.12 Quite Low
Chronic Renal Failure 2 14.96 Low Low
Heart Rate Under Development 2 13.92 Low Low
Disease 2 12.04 Low Low
Hypertension 8 5.00 Very Low Very Low Very Low
Diarrhoea 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Renin is the rate-limiting step of the RAAS and has unique specificity for its substrate, angiotensinogen.
Regulation (has) of angiotensin Binding (specificity) of
1) Confidence 0.44 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350136 Disease Relevance 0.15 Pain Relevance 0.16
Moreover, our data obtained in humans appear to confirm the co-regulatory interaction of COX-2 and angiotensin II in the control of renin release, as suggested by animal studies.


Regulation (confirm) of angiotensin II Binding (interaction) of
2) Confidence 0.29 Published 2001 Journal Swiss Med Wkly Section Body Doc Link 11345810 Disease Relevance 0 Pain Relevance 0
An 11-fold reduction in the affinity of the peptide inhibitor norleucine1-angiotensin IV was observed, whereas the affinity of angiotensin IV remained unaltered.
Regulation (unaltered) of angiotensin IV Binding (affinity) of
3) Confidence 0.01 Published 2008 Journal Biochem. Cell Biol. Section Abstract Doc Link 18523486 Disease Relevance 0.05 Pain Relevance 0.17

General Comments

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