INT95616

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Context Info
Confidence 0.78
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 48
Total Number 49
Disease Relevance 21.51
Pain Relevance 5.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Thpo) extracellular space (Thpo) extracellular region (Thpo)
Anatomy Link Frequency
platelet 14
neurons 3
liver 2
brain 2
central nervous system 2
Thpo (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 30 99.74 Very High Very High Very High
Central nervous system 231 99.68 Very High Very High Very High
Angina 18 99.20 Very High Very High Very High
Inflammation 39 98.92 Very High Very High Very High
Hippocampus 144 98.56 Very High Very High Very High
agonist 45 98.08 Very High Very High Very High
cerebral cortex 112 98.04 Very High Very High Very High
Paracetamol 12 97.48 Very High Very High Very High
Inflammatory response 16 95.12 Very High Very High Very High
ischemia 16 92.64 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 219 100.00 Very High Very High Very High
Hematologic Neoplasms 5 99.98 Very High Very High Very High
Syndrome 74 99.96 Very High Very High Very High
Hypoxia 64 99.96 Very High Very High Very High
Nicotine Addiction 43 99.92 Very High Very High Very High
Hepatotoxicity 3 99.84 Very High Very High Very High
Thrombocytopenia 408 99.78 Very High Very High Very High
Uremia 5 99.78 Very High Very High Very High
Myelofibrosis 19 99.76 Very High Very High Very High
Purpura 20 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test its effect, we used the lethal murine model of myelofibrosis induced by thrombopoietin (TPO) overexpression.
Gene_expression (overexpression) of TPO associated with myelofibrosis
1) Confidence 0.78 Published 2007 Journal Blood Section Abstract Doc Link 17374740 Disease Relevance 1.06 Pain Relevance 0.25
To test its effect, we used the lethal murine model of myelofibrosis induced by thrombopoietin (TPO) overexpression.
Gene_expression (overexpression) of thrombopoietin associated with myelofibrosis
2) Confidence 0.78 Published 2007 Journal Blood Section Abstract Doc Link 17374740 Disease Relevance 1.07 Pain Relevance 0.25
TPO is produced in the liver and levels are low in patients with cirrhosis.
Gene_expression (produced) of TPO in liver associated with cirrhosis
3) Confidence 0.78 Published 2003 Journal Hepatology Section Abstract Doc Link 12601353 Disease Relevance 0.67 Pain Relevance 0.13
To further clarify the data on the developmental pattern of Thpo/Mpl expression, we analysed expression of both genes in the brain of wild-type mice (Additional file 1).
Gene_expression (expression) of Thpo in brain
4) Confidence 0.76 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.03
Thpo mRNA and protein have been detected in neurons, astrocytes and microglia derived from the cerebral cortex and the hippocampi, as well as in Purkinje cells and in granule cells of the cerebellum [3,6].
Gene_expression (detected) of Thpo mRNA in neurons associated with cerebral cortex
5) Confidence 0.76 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.49 Pain Relevance 0.31
Under experimental conditions of hypoxia, Thpo mRNA expression is down-regulated [3,6,8].
Gene_expression (expression) of Thpo mRNA associated with hypoxia
6) Confidence 0.76 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.54 Pain Relevance 0.37
In murine neuronal stem cells, Thpo mRNA was highly expressed, while these cells did not express detectable amounts of Mpl mRNA (Figure 5B).


Gene_expression (expressed) of Thpo mRNA in neuronal stem cells
7) Confidence 0.76 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.08 Pain Relevance 0
Developmental changes in Mpl and Thpo mRNA expression throughout development
Gene_expression (expression) of Thpo mRNA
8) Confidence 0.76 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0.04
Mpl and Thpo mRNA expression in primary neurons, astrocytes, microglia, and neuronal stem cells
Gene_expression (expression) of Thpo mRNA in astrocytes
9) Confidence 0.76 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0 Pain Relevance 0
HYPOTHESIS: In this study, platelets, MPV, and thrombopoietin (TP) levels were investigated in patients with coronary artery disease (CAD) and healthy controls.
Spec (investigated) Gene_expression (levels) of thrombopoietin in coronary artery
10) Confidence 0.74 Published 2001 Journal Clin Cardiol Section Body Doc Link 11346249 Disease Relevance 0 Pain Relevance 0
TPO is primarily produced in the liver and binds to membrane receptors on platelets with a high affinity to be internalized thereafter.23,24 At high platelet counts, most of the circulating TPO is taken up by the platelets and little is left to bind to TPO receptors on megakaryocytes.
Gene_expression (produced) of TPO in liver
11) Confidence 0.72 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880346 Disease Relevance 0.74 Pain Relevance 0
Another concern is that long-term intake of TPO agonists could contribute to carcinogenesis, as the neoplastic cells in many hematopoietic malignancies express TPO receptors.41 Likewise, in 6 of 44 patients with myelodysplasia treated with romiplostim, a transient increase of peripheral blasts was seen.
Gene_expression (express) of TPO associated with agonist, myelodysplastic syndromes and hematologic neoplasms
12) Confidence 0.72 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2880346 Disease Relevance 0.49 Pain Relevance 0.17
We measured TPO and C-reactive protein (CRP), as well as monocyte-platelet binding and the platelet expression of P-selectin and of the TPO receptor, c-Mpl.
Gene_expression (expression) of TPO in platelet
13) Confidence 0.69 Published 2006 Journal J. Am. Coll. Cardiol. Section Body Doc Link 17161245 Disease Relevance 0.08 Pain Relevance 0
The UA patients also showed reduced platelet expression of the TPO receptor, c-Mpl.
Gene_expression (expression) of TPO in platelet
14) Confidence 0.69 Published 2006 Journal J. Am. Coll. Cardiol. Section Body Doc Link 17161245 Disease Relevance 0.06 Pain Relevance 0
Despite severe hepatic dysfunction, serum TPO levels were initially normal and increased during hospitalization in acetaminophen-induced ALF, but did not prevent the development of thrombocytopenia.
Gene_expression (levels) of TPO associated with paracetamol, thrombocytopenia, acute liver failure and hepatotoxicity
15) Confidence 0.67 Published 2003 Journal Hepatology Section Abstract Doc Link 12601353 Disease Relevance 0.96 Pain Relevance 0.31
Thpo is most likely produced locally, since its high molecular weight (about 70-80 kDa) makes its crossing over the intact blood-brain barrier rather unlikely [11].
Gene_expression (produced) of Thpo in brain
16) Confidence 0.66 Published 2010 Journal BMC Dev Biol Section Body Doc Link PMC2921376 Disease Relevance 0.51 Pain Relevance 0.37
Results: Chronic cigarette smokers had higher circulating TPO levels than nonsmoking controls, as well as increased platelet-leukocyte binding, P-selectin expression, and CRP levels.
Gene_expression (levels) of TPO in leukocyte associated with nicotine addiction
17) Confidence 0.64 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 20006331 Disease Relevance 0.88 Pain Relevance 0.11
We then studied the effects of acute smoking and smoking cessation on TPO levels and platelet activation indices.
Gene_expression (levels) of TPO in platelet associated with nicotine addiction
18) Confidence 0.64 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 20006331 Disease Relevance 0.84 Pain Relevance 0.12
Serum cotinine concentrations correlated with TPO concentrations, platelet-monocyte aggregates and P-selectin expression.
Gene_expression (expression) of TPO in platelet
19) Confidence 0.64 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 20006331 Disease Relevance 0.93 Pain Relevance 0.10
In patients with active inflammatory bowel disease, Heits et al. [20], disclosed that the levels of thrombopoietin (TPO), which is the main regulator hormone of platelet production, were significantly increased in association with thrombocytosis and elevated IL-6 levels.
Gene_expression (levels) of thrombopoietin in platelet associated with inflammation and thrombosis related under development
20) Confidence 0.62 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2860341 Disease Relevance 0.96 Pain Relevance 0.29

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