INT95619

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.88
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gck) nucleoplasm (Gck) mitochondrion (Gck)
nucleus (Gck) carbohydrate metabolic process (Gck) kinase activity (Gck)
Gck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 2 68.12 Quite High
Glutamate 15 50.40 Quite High
agonist 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
halothane 3 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 37 95.36 Very High Very High Very High
Stress 18 75.92 Quite High
Apoptosis 3 75.20 Quite High
Hypertrophy 12 67.20 Quite High
Toxicity 6 58.08 Quite High
Body Weight 14 5.00 Very Low Very Low Very Low
Porphyria 9 5.00 Very Low Very Low Very Low
Liver Cancer 6 5.00 Very Low Very Low Very Low
Exsanguination 3 5.00 Very Low Very Low Very Low
Hyperplasia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both direct mapping of changes in gene expression onto the pathways and PLS regression between transcriptional and metabolomic data identified a decrease in glucokinase as being correlated with the decrease in glycogen.
Negative_regulation (decrease) of glucokinase
1) Confidence 0.39 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.13 Pain Relevance 0.03
In this way an association between the decrease in hepatic glycogen and a decrease in glucokinase (hexokinase D) on the glycogen synthesis pathway was identified (figures 5A and 5B, table 3).
Negative_regulation (decrease) of hexokinase D
2) Confidence 0.34 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.15 Pain Relevance 0
In this way an association between the decrease in hepatic glycogen and a decrease in glucokinase (hexokinase D) on the glycogen synthesis pathway was identified (figures 5A and 5B, table 3).
Negative_regulation (decrease) of glucokinase
3) Confidence 0.34 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.15 Pain Relevance 0
This was associated with a strong inhibition (-82%) of the flux through glucokinase and an increase (+83%) of the flux through glycogen synthase, while the flux through glycogen phosphorylase remained unaffected.
Negative_regulation (inhibition) of glucokinase
4) Confidence 0.24 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11346646 Disease Relevance 0 Pain Relevance 0.13
Insulin has been shown to be a potentiator of hexokinase and glucokinase.[13] The decreased levels of glycogen synthase, glucokinase, lactate dehydrogenase, succinate dehydrogenase and malate dehydrogenase may be due to decreased insulin levels in diabetic rats.
Negative_regulation (decreased) of glucokinase associated with diabetes mellitus
5) Confidence 0.09 Published 2008 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2772005 Disease Relevance 0.46 Pain Relevance 0

General Comments

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