INT95621

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Context Info
Confidence 0.64
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 1.06
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gck) nucleoplasm (Gck) mitochondrion (Gck)
nucleus (Gck) carbohydrate metabolic process (Gck) kinase activity (Gck)
Anatomy Link Frequency
liver 2
plasma 1
hypothalamus 1
cerebral cortex 1
beta cells 1
Gck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tramadol 16 98.28 Very High Very High Very High
cerebral cortex 4 97.26 Very High Very High Very High
addiction 4 96.40 Very High Very High Very High
mu opioid receptor 10 91.80 High High
dexamethasone 2 90.56 High High
narcan 4 89.20 High High
Serotonin 2 73.80 Quite High
agonist 4 73.24 Quite High
Central nervous system 2 54.08 Quite High
Paracetamol 2 50.32 Quite High
Disease Link Frequency Relevance Heat
Appetite Loss 129 92.08 High High
Diabetes Mellitus 12 76.68 Quite High
Metabolic Syndrome 4 76.44 Quite High
Stress 6 75.52 Quite High
Obesity 1 71.52 Quite High
Apoptosis 2 17.52 Low Low
Metabolic Disorder 7 17.20 Low Low
Body Weight 17 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 12 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This glucose concentration-dependent activation of metabolism, results in progressive recruitment of more beta cells into a state of activated insulin synthesis [4] and secretion [5], whereby the activation threshold of individual beta cells correlates with their Gck expression and activity [2].
Gene_expression (expression) of Gck in beta cells
1) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997773 Disease Relevance 0 Pain Relevance 0.05
PLS also identified a correlation between decreased plasma lipids and increased hepatic lipoprotein lipase (LPL) at days 7 and 14 (figure 6B) and confirmed the association between decreased in glucokinase expression and decreased hepatic glycogen.


Gene_expression (expression) of glucokinase in plasma
2) Confidence 0.51 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.08 Pain Relevance 0
Low molar Gck abundance fits with the low levels of its mRNA (3, 8 and 240 times lower than that of respectively Gad2, Hadh and Slc2a2/Glut2, our unpublished data).
Gene_expression (abundance) of Gck in molar
3) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997773 Disease Relevance 0 Pain Relevance 0
In livers from S4048-treated rats, mRNA levels of genes encoding Glc-6-P hydrolase (approximately 9-fold), Glc-6-P translocase (approximately 4-fold), glycogen synthase (approximately 7-fold) and L-type pyruvate kinase (approximately 4-fold) were increased, whereas glucokinase expression was almost abolished.
Gene_expression (expression) of glucokinase in livers
4) Confidence 0.44 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11346646 Disease Relevance 0 Pain Relevance 0.05
Glucose utilization of the cerebral cortex and hypothalamus was enhanced by a 4-week-tramadol administration in 90% pancreatectomized rats, in vivo, as assessed by measurement of glucokinase expression and glycogen deposition via activating insulin signaling cascade such as neuronal cells in vitro.
Gene_expression (expression) of glucokinase in hypothalamus associated with tramadol and cerebral cortex
5) Confidence 0.43 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 16140165 Disease Relevance 0.08 Pain Relevance 1.08
In the liver low protein in the diet induces a decrease in the production of glucokinase and increase in phosphoenolpyruvate carboxykinase, two enzymes involved in the glycolytic and gluconeogenic functions, respectively, resulting in a higher level of continuous endogenous glucose production by the liver 10.
Gene_expression (production) of glucokinase in liver
6) Confidence 0.17 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 0.83 Pain Relevance 0
Glucose utilization of the cerebral cortex and hypothalamus was enhanced by a 4-week-tramadol administration in 90% pancreatectomized rats, in vivo, as assessed by measurement of glucokinase expression and glycogen deposition via activating insulin signaling cascade such as neuronal cells in vitro.
Gene_expression (expression) of glucokinase in cerebral cortex associated with tramadol and cerebral cortex
7) Confidence 0.15 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 16140165 Disease Relevance 0.08 Pain Relevance 1.08

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