INT95623

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Context Info
Confidence 0.39
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.91
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gck) nucleoplasm (Gck) mitochondrion (Gck)
nucleus (Gck) carbohydrate metabolic process (Gck) kinase activity (Gck)
Anatomy Link Frequency
liver 4
plasma 2
Gck (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 2 50.32 Quite High
tolerance 6 5.00 Very Low Very Low Very Low
Glutamate 5 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Appetite Loss 129 92.72 High High
Metabolic Syndrome 4 77.08 Quite High
Stress 6 76.04 Quite High
Diabetes Mellitus 4 75.84 Quite High
Obesity 1 71.52 Quite High
Apoptosis 2 18.04 Low Low
Metabolic Disorder 7 17.20 Low Low
Body Weight 17 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 8 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PLS also identified a correlation between decreased plasma lipids and increased hepatic lipoprotein lipase (LPL) at days 7 and 14 (figure 6B) and confirmed the association between decreased in glucokinase expression and decreased hepatic glycogen.


Negative_regulation (decreased) of Gene_expression (expression) of glucokinase in plasma
1) Confidence 0.39 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2826316 Disease Relevance 0.08 Pain Relevance 0
In livers from S4048-treated rats, mRNA levels of genes encoding Glc-6-P hydrolase (approximately 9-fold), Glc-6-P translocase (approximately 4-fold), glycogen synthase (approximately 7-fold) and L-type pyruvate kinase (approximately 4-fold) were increased, whereas glucokinase expression was almost abolished.
Negative_regulation (abolished) of Gene_expression (expression) of glucokinase in livers
2) Confidence 0.33 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11346646 Disease Relevance 0 Pain Relevance 0.05
In the liver low protein in the diet induces a decrease in the production of glucokinase and increase in phosphoenolpyruvate carboxykinase, two enzymes involved in the glycolytic and gluconeogenic functions, respectively, resulting in a higher level of continuous endogenous glucose production by the liver 10.
Negative_regulation (decrease) of Gene_expression (production) of glucokinase in liver
3) Confidence 0.12 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2586678 Disease Relevance 0.84 Pain Relevance 0

General Comments

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