INT95631

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 13.75
Pain Relevance 5.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP8) extracellular space (MMP8) extracellular region (MMP8)
proteinaceous extracellular matrix (MMP8)
Anatomy Link Frequency
coronary artery 5
vessels 5
teeth 4
chondrocytes 2
blood 2
MMP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 108 100.00 Very High Very High Very High
metalloproteinase 78 100.00 Very High Very High Very High
Inflammatory stimuli 1 99.98 Very High Very High Very High
Pain 17 99.90 Very High Very High Very High
Inflammation 358 97.80 Very High Very High Very High
cytokine 36 91.60 High High
Inflammatory mediators 5 77.28 Quite High
Neuropeptide 2 67.96 Quite High
Osteoarthritis 56 50.00 Quite Low
qutenza 8 50.00 Quite Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 70 100.00 Very High Very High Very High
Cv General 3 Under Development 69 100.00 Very High Very High Very High
Pain 11 99.90 Very High Very High Very High
INFLAMMATION 381 99.82 Very High Very High Very High
Hemorrhage 120 99.68 Very High Very High Very High
Acute Coronary Syndrome 245 99.40 Very High Very High Very High
Injury 83 98.96 Very High Very High Very High
Atherosclerotic Plaque 37 98.64 Very High Very High Very High
Atherosclerosis 75 93.84 High High
Myocardial Infarction 116 92.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: These results suggest that capsaicin-evoked neurogenic gingival inflammation can trigger the expression and activation of MMP-8 in GCF of the adjacent teeth.


Positive_regulation (trigger) of Gene_expression (expression) of MMP-8 in teeth
1) Confidence 0.50 Published 2006 Journal J. Periodont. Res. Section Body Doc Link 16409253 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: These results suggest that capsaicin-evoked neurogenic gingival inflammation can trigger the expression and activation of MMP-8 in GCF of the adjacent teeth.


Positive_regulation (activation) of Gene_expression (expression) of MMP-8 in teeth
2) Confidence 0.50 Published 2006 Journal J. Periodont. Res. Section Body Doc Link 16409253 Disease Relevance 0 Pain Relevance 0
To elucidate whether MMP-1, MMP-8 and MMP-13 levels in blood were high in patients with unstable angina (UAP), we measured serum MMP-1 and plasma MMP-8 and MMP-13 levels in 45 patients with UAP, 175 with stable coronary artery disease (CAD), and 45 controls.
Spec (whether) Positive_regulation (elucidate) of Gene_expression (levels) of MMP-8 in blood associated with angina and coronary artery disease
3) Confidence 0.45 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 1.03 Pain Relevance 0.81
Notably, MMP-8 levels were higher in patients with stable CAD than in controls (median 3.5ng/ml vs. 2.8ng/ml, P<0.005), however, MMP-8 levels in patients with UAP were much higher than those in stable CAD (3.9ng/ml vs. 3.5ng/ml, P<0.05).
Positive_regulation (higher) of Gene_expression (levels) of MMP-8 associated with angina and coronary artery disease
4) Confidence 0.45 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 1.59 Pain Relevance 1.18
Analysis of these data indicated that pulpal pain can induce local elevations in MMP-8 levels in GCF.
Positive_regulation (induce) of Gene_expression (levels) of MMP-8 associated with pain and metalloproteinase
5) Confidence 0.41 Published 2005 Journal J. Dent. Res. Section Abstract Doc Link 15790739 Disease Relevance 0.37 Pain Relevance 0.95
Women with PPROM had elevated levels of MMP-8.
Positive_regulation (elevated) of Gene_expression (levels) of MMP-8
6) Confidence 0.24 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1769412 Disease Relevance 0.24 Pain Relevance 0.04
Some authors measured MMP-8 concentrations in 181 patients positive for coronary artery disease (CAD) after angiography and they found that these subjects had higher MMP-8 concentrations, compared with patients without CAD, increasing with the number of stenotic vessels.44
Positive_regulation (had) of Gene_expression (concentrations) of MMP-8 in vessels associated with coronary artery disease
7) Confidence 0.15 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.26 Pain Relevance 0.15
Some authors measured MMP-8 concentrations in 181 patients positive for coronary artery disease (CAD) after angiography and they found that these subjects had higher MMP-8 concentrations, compared with patients without CAD, increasing with the number of stenotic vessels.44
Positive_regulation (after) of in coronary artery Gene_expression (concentrations) of MMP-8 in vessels associated with coronary artery disease
8) Confidence 0.15 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.28 Pain Relevance 0.16
Some authors measured MMP-8 concentrations in 181 patients positive for coronary artery disease (CAD) after angiography and they found that these subjects had higher MMP-8 concentrations, compared with patients without CAD, increasing with the number of stenotic vessels.44
Positive_regulation (measured) of Gene_expression (concentrations) of MMP-8 in coronary artery associated with coronary artery disease
9) Confidence 0.15 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.18 Pain Relevance 0.16
Some authors measured MMP-8 concentrations in 181 patients positive for coronary artery disease (CAD) after angiography and they found that these subjects had higher MMP-8 concentrations, compared with patients without CAD, increasing with the number of stenotic vessels.44
Positive_regulation (after) of Gene_expression (concentrations) of MMP-8 in coronary artery associated with coronary artery disease
10) Confidence 0.15 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.21 Pain Relevance 0.16
Some authors measured MMP-8 concentrations in 181 patients positive for coronary artery disease (CAD) after angiography and they found that these subjects had higher MMP-8 concentrations, compared with patients without CAD, increasing with the number of stenotic vessels.44
Positive_regulation (higher) of Gene_expression (concentrations) of MMP-8 in vessels associated with coronary artery disease
11) Confidence 0.15 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.26 Pain Relevance 0.15
Immunoassays for interleukin-6 (IL-6) and matrix metalloprotease-8 (MMP-8)
Positive_regulation (for) of Gene_expression (Immunoassays) of MMP-8
12) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 0.52 Pain Relevance 0.13
The bleeding alone group was characterized by elevated LDH activity levels in the context of a higher RBC (but not WBC) count, and normal IL-6 and MMP-8 levels.
Positive_regulation (elevated) of Gene_expression (levels) of MMP-8 associated with hemorrhage
13) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 1.26 Pain Relevance 0.27
This was determined to be in sharp contrast to the women who had the inflammation profile present (with or without bleeding) who had significantly lower glucose and elevated LDH activity, WBC, RBC counts and elevated levels of IL-6 and MMP-8.
Positive_regulation (elevated) of Gene_expression (levels) of MMP-8 associated with inflammation and hemorrhage
14) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 1.03 Pain Relevance 0.28
Inflammatory stimuli augment the production of the interstitial collagenases MMP-1, MMP-13, MMP-8 from several cell types found in atherosclerotic plaques.
Positive_regulation (augment) of Gene_expression (production) of MMP-8 in plaques associated with atherosclerotic plaque and inflammatory stimuli
15) Confidence 0.08 Published 2008 Journal Biomarker Insights Section Body Doc Link PMC2688349 Disease Relevance 1.18 Pain Relevance 0.30
Studies with cartilage explants that are subjected to mechanical impact injury demonstrate that the remaining viable chondrocytes express increased levels of matrix metalloproteinase (MMP)-1, MMP-3, MMP-8, MMP-9, MMP-13 and ADAM-TS5 [46,47].
Positive_regulation (increased) of Gene_expression (express) of MMP-8 in chondrocytes associated with injury and metalloproteinase
16) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911903 Disease Relevance 0.36 Pain Relevance 0.38
The elevated levels of MMP-2, MMP-9, and MMP-8 in the SF of patients with mild TMJ-ID eventually reflect the active phase of TMJ destruction.
Positive_regulation (elevated) of Gene_expression (levels) of MMP-8
17) Confidence 0.02 Published 2001 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 11346728 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox