INT95632

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 26
Disease Relevance 10.06
Pain Relevance 9.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP8) extracellular space (MMP8) extracellular region (MMP8)
proteinaceous extracellular matrix (MMP8)
Anatomy Link Frequency
tooth 7
neutrophil 2
chondrocytes 1
PMNL 1
plaques 1
MMP8 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 270 100.00 Very High Very High Very High
Neuropeptide 14 100.00 Very High Very High Very High
substance P 8 100.00 Very High Very High Very High
Pain 53 99.98 Very High Very High Very High
qutenza 32 99.70 Very High Very High Very High
Inflammation 315 98.32 Very High Very High Very High
Inflammatory mediators 13 97.08 Very High Very High Very High
Osteoarthritis 71 96.36 Very High Very High Very High
cytokine 52 93.32 High High
long-term potentiation 4 78.16 Quite High
Disease Link Frequency Relevance Heat
Pain 43 99.98 Very High Very High Very High
Metabolic Syndrome 10 99.72 Very High Very High Very High
Periodontal Disease 48 99.36 Very High Very High Very High
Hemorrhage 83 99.16 Very High Very High Very High
Injury 60 98.80 Very High Very High Very High
Atherosclerotic Plaque 1 98.36 Very High Very High Very High
INFLAMMATION 342 98.32 Very High Very High Very High
Alveolar Bone Loss 1 98.28 Very High Very High Very High
Osteoarthritis 16 96.36 Very High Very High Very High
Adhesions 1 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Capsaicin stimulation of the alveolar mucosa induced significant local elevations in levels and activation of MMP-8 in GCF of the adjacent teeth.
Positive_regulation (activation) of MMP-8 in teeth
1) Confidence 0.70 Published 2006 Journal J. Periodont. Res. Section Body Doc Link 16409253 Disease Relevance 0 Pain Relevance 0
Painful tooth stimulation elevates matrix metalloproteinase-8 levels locally in human gingival crevicular fluid.
Positive_regulation (elevates) of matrix metalloproteinase-8 in tooth associated with pain and metalloproteinase
2) Confidence 0.69 Published 2005 Journal J. Dent. Res. Section Title Doc Link 15790739 Disease Relevance 0.36 Pain Relevance 0.97
Painful stimulation of the upper incisor provoked significant elevations in GCF MMP-8 levels of the stimulated tooth.
Positive_regulation (elevations) of GCF MMP-8 in upper associated with pain and metalloproteinase
3) Confidence 0.69 Published 2005 Journal J. Dent. Res. Section Abstract Doc Link 15790739 Disease Relevance 0.31 Pain Relevance 1.01
Experimental tooth pain elevates substance P and matrix metalloproteinase-8 levels in human gingival crevice fluid.
Positive_regulation (elevates) of matrix metalloproteinase-8 in tooth associated with pain, metalloproteinase and substance p
4) Confidence 0.59 Published 2008 Journal Acta Odontol. Scand. Section Title Doc Link 18320414 Disease Relevance 0.38 Pain Relevance 0.77
With this background, we wished to study whether capsaicin stimulation of alveolar mucosa can induce changes in the GCF MMP-8 levels.
Positive_regulation (induce) of GCF MMP-8 associated with qutenza
5) Confidence 0.50 Published 2006 Journal J. Periodont. Res. Section Abstract Doc Link 16409253 Disease Relevance 0.52 Pain Relevance 0.59
Capsaicin-induced local elevations in collagenase-2 (matrix metalloproteinase-8) levels in human gingival crevice fluid.
Positive_regulation (elevations) of collagenase-2 associated with qutenza and metalloproteinase
6) Confidence 0.47 Published 2006 Journal J. Periodont. Res. Section Title Doc Link 16409253 Disease Relevance 0.55 Pain Relevance 0.75
CONCLUSIONS: These results suggest that capsaicin-evoked neurogenic gingival inflammation can trigger the expression and activation of MMP-8 in GCF of the adjacent teeth.


Positive_regulation (activation) of MMP-8 in teeth
7) Confidence 0.47 Published 2006 Journal J. Periodont. Res. Section Body Doc Link 16409253 Disease Relevance 0 Pain Relevance 0
Capsaicin-induced local elevations in collagenase-2 (matrix metalloproteinase-8) levels in human gingival crevice fluid.
Positive_regulation (elevations) of matrix metalloproteinase-8 associated with qutenza and metalloproteinase
8) Confidence 0.47 Published 2006 Journal J. Periodont. Res. Section Title Doc Link 16409253 Disease Relevance 0.55 Pain Relevance 0.75
RESULTS: Painful stimulation of the upper central incisor caused significant elevations in GCF SP and MMP-8 levels of the stimulated tooth.
Positive_regulation (elevations) of MMP-8 in incisor
9) Confidence 0.46 Published 2008 Journal Acta Odontol. Scand. Section Body Doc Link 18320414 Disease Relevance 0.08 Pain Relevance 0
During the experiments, no marked changes occurred in MMP-8 levels in the GCF of distantly located teeth.
Neg (no) Positive_regulation (occurred) of MMP-8 in teeth
10) Confidence 0.44 Published 2006 Journal J. Periodont. Res. Section Body Doc Link 16409253 Disease Relevance 0 Pain Relevance 0
High levels of MMPs mRNA and proteins, especially MMP-1, MMP-2, MMP-8, MMP-9, and MMP-13, were shown in human atherosclerotic plaques.
Positive_regulation (levels) of MMP-8 in plaques associated with atherosclerotic plaque and metalloproteinase
11) Confidence 0.42 Published 2010 Journal Atherosclerosis Section Abstract Doc Link 19674746 Disease Relevance 0.64 Pain Relevance 0.59
This capsaicin-evoked MMP-8 elevation lasted several minutes after stimulation.
Positive_regulation (elevation) of MMP-8
12) Confidence 0.41 Published 2006 Journal J. Periodont. Res. Section Body Doc Link 16409253 Disease Relevance 0 Pain Relevance 0
Western immunoblot revealed that both neutrophil- and mesenchymal-type MMP-8 isoforms were elevated and activated, together with 110 kDa high-molecular size MMP-8 species.
Positive_regulation (elevated) of MMP-8 in neutrophil
13) Confidence 0.41 Published 2006 Journal J. Periodont. Res. Section Body Doc Link 16409253 Disease Relevance 0 Pain Relevance 0
Western immunoblot revealed elevations in both neutrophil- and mesenchymal-type MMP-8 isoforms.
Positive_regulation (elevations) of MMP-8 in neutrophil associated with metalloproteinase
14) Confidence 0.41 Published 2005 Journal J. Dent. Res. Section Abstract Doc Link 15790739 Disease Relevance 0.30 Pain Relevance 1.00
CONCLUSIONS: These data indicate that experimental tooth pain can induce local elevations of SP and MMP-8 levels in GCF simultaneously.
Positive_regulation (elevations) of MMP-8 in tooth
15) Confidence 0.40 Published 2008 Journal Acta Odontol. Scand. Section Body Doc Link 18320414 Disease Relevance 0.07 Pain Relevance 0
With this background, we studied whether experimental tooth pain can trigger changes in GCF levels of the neuropeptide substance P (SP) and MMP-8.
Positive_regulation (trigger) of MMP-8 in tooth associated with pain, metalloproteinase, neuropeptide and substance p
16) Confidence 0.40 Published 2008 Journal Acta Odontol. Scand. Section Abstract Doc Link 18320414 Disease Relevance 0.43 Pain Relevance 0.75
The laboring groups had higher concentrations of MMP-8 and MMP-9, where the difference was statistically significant between the term in labor and not in labor groups (Fig. 2).
Positive_regulation (concentrations) of MMP-8 associated with metalloproteinase
17) Confidence 0.16 Published 2008 Journal Molecular Human Reproduction Section Body Doc Link PMC2639405 Disease Relevance 0.08 Pain Relevance 0.70
Women with PPROM had elevated levels of MMP-8.
Positive_regulation (elevated) of MMP-8
18) Confidence 0.16 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1769412 Disease Relevance 0.24 Pain Relevance 0.04
This was determined to be in sharp contrast to the women who had the inflammation profile present (with or without bleeding) who had significantly lower glucose and elevated LDH activity, WBC, RBC counts and elevated levels of IL-6 and MMP-8.
Positive_regulation (elevated) of MMP-8 associated with inflammation and hemorrhage
19) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2315798 Disease Relevance 1.04 Pain Relevance 0.29
Interestingly, similar to what we have found in our case, patients with metabolic syndrome also display increased circulating concentrations of pro-MMP-9, MMP-8, and TIMP-1, which were associated with increased concentrations of pro-inflammatory mediators and adhesion molecules [28].
Positive_regulation (increased) of MMP-8 associated with inflammatory mediators, metabolic syndrome and adhesions
20) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820097 Disease Relevance 1.11 Pain Relevance 0.55

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