INT95636

Context Info Confidence 0.44 First Reported 2001 Last Reported 2010 Negated 3 Speculated 0 Reported most in Body Documents 23 Total Number 25 Disease Relevance 19.87 Pain Relevance 1.75

cytosol (ACTG2) cytoskeleton (ACTG2) cytoplasm (ACTG2)

Anatomy Link Frequency smooth muscle 11 muscle 7 leukocytes 2 stromal cells 2 adipose tissue 1 ACTG2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory marker 2 96.96 Lasting pain 2 94.48 Pain 67 90.68 cINOD 34 87.84 agonist 63 85.04 headache 1 83.44 imagery 10 82.20 pain flank 6 81.08 Inflammation 60 78.08 ischemia 49 76.60

Disease Link Frequency Relevance Heat Cancer 418 99.86 Fibroma 76 98.84 Necrosis 23 98.16 Desmoid Disease 75 97.32 INFLAMMATION 72 96.96 Nasal Tumor 37 96.96 Fibrosis 2 96.80 Obesity 10 96.72 Rotator Cuff Tears 2 96.40 Gastrointestinal Stromal Tumor 146 95.80

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Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunohistochemically, these rhabdoid cells were positive for vimentin, epithelial membrane antigen, smooth-muscle actin, cytokeratin, S-100 protein, and glial fibrillary acidic protein.

Gene_expression (positive) of smooth-muscle actin in muscle

1) Confidence 0.44 Published 2007 Journal Arq Neuropsiquiatr Section Abstract Doc Link 17876420 Disease Relevance 1.12 Pain Relevance 0.15

The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff.

Gene_expression (presence) of smooth muscle actin in fibroblasts

2) Confidence 0.44 Published 2001 Journal J. Orthop. Res. Section Title Doc Link 11347694 Disease Relevance 0.28 Pain Relevance 0.09

Differential expression analysis of the metastatic and primary tumor samples shows that a large number of the most highly downregulated genes such as TAGLN, ACTG2, TPM1, MYH111 and DES have been previously identified as expressed mostly in the prostatic stromal cells [15].

Gene_expression (expressed) of ACTG2 in stromal cells associated with cancer

3) Confidence 0.44 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 0.52 Pain Relevance 0

The provided tissue (0.5 cm3) was diagnostic for nasopharyngeal angiofibroma after routine hematoxylin and eosin (H&E) staining (Figure 1), the stromal cells were negative for both cluster of differentiation (CD) 34 antigen and smooth muscle actin (SMA) antibodies and C-kit antibody was rarely detected in single cells.

Gene_expression (antibodies) of smooth muscle actin in stromal cells associated with nasal tumor

4) Confidence 0.39 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2535598 Disease Relevance 1.02 Pain Relevance 0

Fragments of the tumor were fixed in 10% formaldehyde, included in paraffin, and the sections were stained with HE, VG and immunohistochemically with vimentin (VIM), MNF116, SyN, smooth muscle actin (ACT), desmin, CD68, S100, HMB45, and CD117.

Gene_expression (stained) of smooth muscle actin in smooth muscle associated with cancer

5) Confidence 0.35 Published 2007 Journal Rom J Morphol Embryol Section Abstract Doc Link 18060198 Disease Relevance 0.92 Pain Relevance 0.23

The notable finding of this study was the presence of a contractile actin isoform, alpha-smooth muscle actin (SMA), in nonvascular cells in all of the seven torn human rotator cuff specimens evaluated immunohistochemically.

Gene_expression (presence) of smooth muscle actin in smooth muscle

6) Confidence 0.33 Published 2001 Journal J. Orthop. Res. Section Abstract Doc Link 11347694 Disease Relevance 0.28 Pain Relevance 0.09

Smooth muscle actin (SMA) was positive in two of the four cases of CMF (50%; 2/4) [Figure 5C].

Gene_expression (positive) of Smooth muscle actin in Smooth muscle associated with fibroma

7) Confidence 0.33 Published 2007 Journal Diagn Pathol Section Body Doc Link PMC2203974 Disease Relevance 0.96 Pain Relevance 0

The tumor cells were positive for CD99 and bcl-2 in all cases and for CD56 in two cases and negative for CD34 and smooth muscle actin in all cases.

Neg (negative) Gene_expression (negative) of smooth muscle actin in smooth muscle associated with cancer

8) Confidence 0.31 Published 2004 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 15105652 Disease Relevance 1.17 Pain Relevance 0.06

Immunohistochemical analysis showed that the tumour cells expressed vimentin, but not smooth-muscle actin, CD34, or desmin.

Neg (not) Gene_expression (expressed) of smooth-muscle actin in muscle associated with cancer

9) Confidence 0.27 Published 2008 Journal World J Surg Oncol Section Abstract Doc Link PMC2270274 Disease Relevance 1.77 Pain Relevance 0.29

Immunohistochemical analysis showed that the tumour cells expressed vimentin, but not smooth-muscle actin (SMA), CD34, or desmin.

Gene_expression (expressed) of smooth-muscle actin in muscle associated with cancer

10) Confidence 0.27 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2270274 Disease Relevance 1.93 Pain Relevance 0.13

Defensin antibodies were visualized with an excitation filter of 555 nm (bandpass of 28 nm) and an emission filter of 617 nm (bandpass of 73 nm) and smooth muscle actin was acquired with an excitation filter of 640 nm (bandpass 20 nm) and emission filter of 685 (bandpass of 40 nm).

Gene_expression (acquired) of smooth muscle actin in smooth muscle

11) Confidence 0.23 Published 2010 Journal Eplasty Section Body Doc Link PMC2803769 Disease Relevance 0.07 Pain Relevance 0

The tumour cells expressed S-100 protein and glial fibrillary acidic protein (GFAP) and were negative for HMB45, melan A, smooth muscle actin (SMA), desmin, CD34 and CD117.

Neg (negative) Gene_expression (negative) of smooth muscle actin in smooth muscle associated with cancer

12) Confidence 0.21 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2430707 Disease Relevance 0.66 Pain Relevance 0

The majority of GISTs are usually positive for CD117 (near 95% of cases), CD34 (positive in 70–80% of cases), smooth muscle actin (positive in 40% of cases), PS 100 (positive near 5% of cases), and desmin (positive in approximately 2% of cases) [1-3].

Gene_expression (positive) of smooth muscle actin in smooth muscle

13) Confidence 0.18 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2034569 Disease Relevance 0.99 Pain Relevance 0

The tumor cells coexpressed CD34 and smooth muscle actin and were negative for staining desmin and S-100 protein.

Gene_expression (coexpressed) of smooth muscle actin in smooth muscle associated with cancer

14) Confidence 0.13 Published 2002 Journal Harefuah Section Abstract Doc Link 12534196 Disease Relevance 1.38 Pain Relevance 0.07

In particular, geNorm classifies GAPDH and Act-B as the best two controls of the group (Table 2), while the best position in the stability ranking produced by NormFinder is occupied by Act-B, followed by hCyPB, GAPDH and HPRT1 (Table 2).

Gene_expression (classifies) of Act-B

15) Confidence 0.11 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 0 Pain Relevance 0.05

All the four house-keeping genes tested in this work (Act-B, GAPDH, hCyPB, HPRT1) were classified as optimal controls and showed a constant expression in human leukocytes samples.

Gene_expression (expression) of Act-B in leukocytes

16) Confidence 0.10 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2588574 Disease Relevance 0.07 Pain Relevance 0.15

All four house-keeping genes considered in this study (Act-B, GAPDH, hCyPB, HPRT1) were classified as optimal controls and showed stable expression in human leukocytes samples.

Gene_expression (expression) of Act-B in leukocytes

17) Confidence 0.10 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588574 Disease Relevance 0 Pain Relevance 0

To clarify the development of the subepithelial spaces, the basement membrane, demarcating the lamina propria from the epithelial cells, and the underlying network of myofibroblasts within the villus lamina propria were studied, by staining collagen IV and smooth muscle actin (SMA), respectively [29], [30].

Gene_expression (staining) of smooth muscle actin in smooth muscle

18) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561292 Disease Relevance 0.19 Pain Relevance 0.10

Tumour cells were strongly immunolabelled for vimentin and some expressed smooth-muscle actin and desmin.

Gene_expression (expressed) of smooth-muscle actin in muscle associated with cancer

19) Confidence 0.07 Published 2003 Journal J. Comp. Pathol. Section Abstract Doc Link 12634100 Disease Relevance 0.68 Pain Relevance 0.09

Typically the IMT is characterized by the expression of vimentin, smooth muscle actin, and cytokeratins, corresponded to that of myofibroblasts along with other inflammatory markers [10].

Gene_expression (expression) of smooth muscle actin in smooth muscle associated with cancer and inflammatory marker

20) Confidence 0.06 Published 2005 Journal World J Surg Oncol Section Body Doc Link PMC1276822 Disease Relevance 1.77 Pain Relevance 0.21

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