INT95641

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.67
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Fbn1) proteinaceous extracellular matrix (Fbn1)
Anatomy Link Frequency
skin 4
Fbn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 2 99.98 Very High Very High Very High
Pain 6 99.80 Very High Very High Very High
fibrosis 43 97.32 Very High Very High Very High
analgesia 1 89.52 High High
topical agent 1 88.72 High High
anesthesia 1 38.84 Quite Low
cytokine 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 96 99.28 Very High Very High Very High
Systemic Sclerosis 22 99.04 Very High Very High Very High
Pain 4 98.36 Very High Very High Very High
Fibrosis 45 97.32 Very High Very High Very High
Marfan Syndrome 12 96.72 Very High Very High Very High
Disease 11 93.24 High High
Ectopia Lentis 4 90.12 High High
Contracture 8 89.00 High High
Cleidocranial Dysplasia 64 86.04 High High
Injury 18 84.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study indicates that all-trans retinoic acid can significantly affect fibrillin-1 content in photoaged skin.
Regulation (affect) of fibrillin-1 in skin
1) Confidence 0.45 Published 2001 Journal J. Invest. Dermatol. Section Abstract Doc Link 11348454 Disease Relevance 0.16 Pain Relevance 0.04
It seems that an altered FBN-1/TGF-?
Spec (seems) Regulation (altered) of FBN-1
2) Confidence 0.44 Published 2008 Journal Radiat Oncol Section Body Doc Link PMC2599892 Disease Relevance 1.11 Pain Relevance 0.16
Analgesic effects of skin-to-skin contact and breastfeeding in procedural pain in healthy term neonates.
Regulation (effects) of skin-to-skin in skin associated with pain and analgesic
3) Confidence 0.37 Published 2010 Journal Ann Trop Paediatr Section Title Doc Link 20522298 Disease Relevance 0.19 Pain Relevance 0.58
Recently, domain-specific mutations affecting fibrillin-1 were reported in SSS, the cardinal manifestation of which is skin fibrosis and restricted joint movement [10].
Regulation (affecting) of fibrillin-1 in skin associated with fibrosis and syndrome
4) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941456 Disease Relevance 1.35 Pain Relevance 0.08
In this respect, it resembles human stiff skin syndrome and the Tight skin mouse, each of which is caused by gene defects affecting fibrillin-1, a major component of tissue microfibrils.
Regulation (affecting) of fibrillin-1 in skin associated with syndrome
5) Confidence 0.31 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2941456 Disease Relevance 0.86 Pain Relevance 0.05

General Comments

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