INT95652

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2010
Negated 29
Speculated 2
Reported most in Body
Documents 54
Total Number 56
Disease Relevance 53.69
Pain Relevance 3.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Krt20) structural molecule activity (Krt20) cytoplasm (Krt20)
Anatomy Link Frequency
blood 3
colon 2
upper 2
bladder 1
epithelium 1
Krt20 (Mus musculus)
Pain Link Frequency Relevance Heat
Bile 27 98.48 Very High Very High Very High
Serotonin 1 97.92 Very High Very High Very High
Pain 22 92.96 High High
imagery 88 92.88 High High
Inflammation 9 92.20 High High
endometriosis 7 90.04 High High
abdominal pain 13 84.92 Quite High
Dysuria 3 83.92 Quite High
backache 3 83.24 Quite High
palliative 26 82.48 Quite High
Disease Link Frequency Relevance Heat
Mucinous Adenocarcinoma 32 99.98 Very High Very High Very High
Adenocarcinoma 337 99.88 Very High Very High Very High
Cancer 1066 99.84 Very High Very High Very High
Colon Cancer 233 99.84 Very High Very High Very High
Intestinal Cancer 5 99.64 Very High Very High Very High
Renal Cancer 29 99.54 Very High Very High Very High
Ovarian Cancer 220 99.14 Very High Very High Very High
Leydig Cell Tumor 13 98.84 Very High Very High Very High
Malignant Neoplastic Disease 89 98.60 Very High Very High Very High
Endometroid Carcinoma 3 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The tumor cells, intrahepatic bile ducts, and ductules were consistently reactive with cytokeratin (CK) 7 and negative for CK20.
Neg (negative) Gene_expression (negative) of CK20 in ductules associated with bile and cancer
1) Confidence 0.61 Published 2004 Journal Surg. Today Section Abstract Doc Link 15526136 Disease Relevance 1.22 Pain Relevance 0.16
It is also well described that monitoring expression of Krt7 and Krt20 could distinguish between ovarian and gastro-intestinal tract tumors (reviewed in [60]).
Gene_expression (expression) of Krt20 associated with cancer
2) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.70 Pain Relevance 0
Both the 1946 and the 2223 patients presented different epithelium specific Krt expression (Figure 2A and 2E) but did not express Krt20.
Neg (not) Gene_expression (express) of Krt20 in epithelium
3) Confidence 0.50 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.88 Pain Relevance 0
Immunohistochemically, the tumor cells were stained positive for cytokeratin (CK) AE1/AE3 and partially positive for CK7, but negative for CK20.
Neg (negative) Gene_expression (negative) of CK20 associated with cancer
4) Confidence 0.48 Published 2009 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19498300 Disease Relevance 0.44 Pain Relevance 0.16
Immunohistochemical studies showed that 29 of 29 tumors (100%) were positive for CK20; focal CK7 positivity was seen in 5 of 30 cases (17%).
Gene_expression (positive) of CK20 associated with cancer
5) Confidence 0.47 Published 2006 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16434891 Disease Relevance 1.21 Pain Relevance 0.07
Taken together, the expression patterns of CEA, CK20 and CK7 conform well to previous observations in PMP, and findings within each of the two models were consistent throughout the examined passages.
Gene_expression (expression) of CK20 associated with pseudomyxoma peritonei
6) Confidence 0.40 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1920528 Disease Relevance 1.05 Pain Relevance 0
The uniformly high expression of CK20 is also in agreement with previously published results and with the appendiceal origin of PMP [1].
Gene_expression (expression) of CK20 associated with pseudomyxoma peritonei
7) Confidence 0.40 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1920528 Disease Relevance 1.24 Pain Relevance 0
The two intestinal tumor markers, CEA and CK20, were highly expressed in both primary tumors, main surgical specimens and in all specimens harvested from the first six animal passages, with membranous and cytoplasmic staining observed in 100% of tumor cells in all but one section.
Gene_expression (expressed) of CK20 associated with cancer and intestinal cancer
8) Confidence 0.35 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1920528 Disease Relevance 0.99 Pain Relevance 0
The gastro-intestinal tract tumor marker Krt20 was absent in both tumor tissues and all cell lines (Figure 2B and 2F).
Neg (absent) Gene_expression (absent) of Krt20 associated with cancer
9) Confidence 0.34 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2467432 Disease Relevance 0.80 Pain Relevance 0
Taken together, the expression patterns of CEA, CK20 and CK7 conform well to previous observations in PMP, and findings within each of the two models were consistent throughout the examined passages.
Gene_expression (patterns) of CK20 associated with pseudomyxoma peritonei
10) Confidence 0.31 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1920528 Disease Relevance 1.05 Pain Relevance 0
Immunohistochemistry showed that the adenocarcinoma cells were diffusely positive for cytokeratin 20 (CK20) and caudal-type homeobox transcription factor-2 (CDX2) but negative for CK7, confirming the colonic phenotype.
Neg (negative) Gene_expression (positive) of CK20 associated with adenocarcinoma
11) Confidence 0.31 Published 2008 Journal Pathol. Int. Section Abstract Doc Link 19067855 Disease Relevance 1.25 Pain Relevance 0.08
Immunohistochemistry showed that the adenocarcinoma cells were diffusely positive for cytokeratin 20 (CK20) and caudal-type homeobox transcription factor-2 (CDX2) but negative for CK7, confirming the colonic phenotype.
Neg (negative) Gene_expression (positive) of cytokeratin 20 associated with adenocarcinoma
12) Confidence 0.31 Published 2008 Journal Pathol. Int. Section Abstract Doc Link 19067855 Disease Relevance 1.25 Pain Relevance 0.08
The tumor cells were immunopositive for cytokeratin 7, but negative for cytokeratin 20, and the tumor was histologically diagnosed as endometrioid adenocarcinoma of the mesocolon.
Neg (negative) Gene_expression (negative) of cytokeratin 20 associated with endometroid carcinoma and cancer
13) Confidence 0.25 Published 2005 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 15741306 Disease Relevance 1.41 Pain Relevance 0.26
Denis et al. demonstrated CTC in whole blood samples in 4 of 5 patients with metastatic CRC using mAb BerEP coated magnetic beads and subsequent analysis with RT-PCR assays for CK8, CK19 and CK20 gene expression [15].
Gene_expression (expression) of CK20 gene in blood associated with colon cancer
14) Confidence 0.23 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2868015 Disease Relevance 0.51 Pain Relevance 0
The human colon cancer cell line HT29 expressing EpCAM and Cytokeratin 20 (CK20) was purchased from American Type Cell Culture (Austria Branch).
Gene_expression (expressing) of CK20 in colon associated with colon cancer
15) Confidence 0.23 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2868015 Disease Relevance 0.33 Pain Relevance 0.06
An immunohistochemical examination of cytokeratin (CK) 7 and CK20 exhibited CK7 (+)/CK20 (-) tumors in the primary and metastatic lesions.
Gene_expression (exhibited) of CK20 associated with cancer
16) Confidence 0.21 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2917439 Disease Relevance 1.62 Pain Relevance 0.13
An immunohistochemical examination of cytokeratin (CK) 7 and CK20 exhibited CK7 (+)/CK20 (-) tumors in the primary and metastatic lesions.
Gene_expression (exhibited) of CK20 associated with cancer
17) Confidence 0.21 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2917439 Disease Relevance 1.57 Pain Relevance 0.13
This result differed from the profile of CK7/CK20 in CRC and was compatible with the profile of CK7/CK20 in SBA reported previously [14].
Gene_expression (profile) of CK20 associated with adenocarcinoma and colon cancer
18) Confidence 0.21 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2917439 Disease Relevance 1.65 Pain Relevance 0.11
The tumor cells, intrahepatic bile ducts, and ductules were consistently reactive with cytokeratin (CK) 7 and negative for CK20.
Neg (negative) Gene_expression (negative) of CK20 in intrahepatic bile ducts associated with bile and cancer
19) Confidence 0.21 Published 2004 Journal Surg. Today Section Abstract Doc Link 15526136 Disease Relevance 1.22 Pain Relevance 0.16
As for clear cell RCC, lack of both CK7 and CK20 expression has been found [15-17], although papillary and chromophobe RCC were reported to have some CK7 expression [18-20].
Gene_expression (expression) of CK20 associated with renal cancer
20) Confidence 0.21 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2858138 Disease Relevance 1.14 Pain Relevance 0

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