INT95655

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.66
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (MKI67) nucleolus (MKI67) nucleus (MKI67)
intracellular (MKI67) cell cycle (MKI67) DNA metabolic process (MKI67)
MKI67 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dismenorea 4 99.08 Very High Very High Very High
imagery 1 69.88 Quite High
cytokine 2 46.24 Quite Low
cva 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stomach Cancer 24 99.84 Very High Very High Very High
Carcinoma 8 99.36 Very High Very High Very High
Dysmenorrhea 4 99.08 Very High Very High Very High
Breast Cancer 57 98.52 Very High Very High Very High
Endometroid Carcinoma 3 98.08 Very High Very High Very High
Cancer 150 97.76 Very High Very High Very High
Disease 13 95.08 Very High Very High Very High
Malignant Neoplastic Disease 9 88.12 High High
Adenocarcinoma 3 87.16 High High
Endometriosis (extended) 6 81.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry showed expression of p53 oncoprotein and Ki-67 antigen in the carcinoma cells.
Negative_regulation (showed) of Gene_expression (expression) of Ki-67 associated with carcinoma
1) Confidence 0.41 Published 2001 Journal Pathol. Int. Section Abstract Doc Link 11350616 Disease Relevance 1.32 Pain Relevance 0.36
Ki-67 expression in benign breast cells obtained from RPFNA is also a reversible, a potential risk and a possible surrogate response biomarker.
Spec (possible) Negative_regulation (reversible) of Gene_expression (expression) of Ki-67
2) Confidence 0.37 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1929099 Disease Relevance 0.40 Pain Relevance 0
After treatment with NCTD, the expression of PCNA (0.932+/-0.031 vs. 0.318+/-0.023, P<0.001) and Ki-67 (0.964+/-0.092 vs. 0.297+/-0.018, P<0.001) proteins were decreased significantly.
Negative_regulation (decreased) of Gene_expression (expression) of Ki-67
3) Confidence 0.31 Published 2004 Journal HBPD INT Section Body Doc Link 15567755 Disease Relevance 0.07 Pain Relevance 0
As reviewed by Brown and Gatter [27], the PI of any tissue is determined by the growth fraction, which can be assessed by Ki-67 expression, and the time it takes the cell to complete the cell cycle.
Negative_regulation (assessed) of Gene_expression (expression) of Ki-67
4) Confidence 0.17 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1143573 Disease Relevance 0.14 Pain Relevance 0
The third aim of this study was to examine the expression of COX-2, p53, and Ki-67 in gastric cancer and their relationship with clinicopathological characteristics including patient prognosis.
Spec (examine) Negative_regulation (examine) of Spec (examine) Gene_expression (expression) of Ki-67 associated with stomach cancer
5) Confidence 0.09 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721998 Disease Relevance 1.05 Pain Relevance 0
Consistent with this finding, Miller and colleagues also reported that neoadjuvant letrozole produces rapid and profound decreases in expression of Ki67 and PgR that do not always correlate with clinical and pathological responses [47].


Negative_regulation (decreases) of Gene_expression (expression) of Ki67
6) Confidence 0.03 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001223 Disease Relevance 0.69 Pain Relevance 0

General Comments

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