INT95667

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Context Info
Confidence 0.22
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.95
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb2) signal transduction (Nfkb2) nucleus (Nfkb2)
extracellular matrix organization (Nfkb2) DNA binding (Nfkb2) cytoplasm (Nfkb2)
Anatomy Link Frequency
macrophage 1
Nfkb2 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1 99.80 Very High Very High Very High
Pain 2 90.76 High High
iatrogenic 1 83.76 Quite High
Paracetamol 5 76.32 Quite High
Inflammatory mediators 1 70.64 Quite High
Inflammation 1 68.24 Quite High
chemokine 2 68.08 Quite High
Arthritis 1 67.20 Quite High
Analgesic 1 55.64 Quite High
Disease Link Frequency Relevance Heat
Necrosis 1 99.34 Very High Very High Very High
Apoptosis 5 99.26 Very High Very High Very High
Cancer 2 99.16 Very High Very High Very High
Bone Disease 5 98.36 Very High Very High Very High
Adhesions 1 98.12 Very High Very High Very High
Osteogenic Sarcomas 10 97.56 Very High Very High Very High
Targeted Disruption 6 95.84 Very High Very High Very High
Osteoporosis 1 92.60 High High
Hypercalcemia 1 92.08 High High
Pain 2 90.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conclusion: The decreased rate of apoptosis in the knockout mice correlated with an almost undetectable and significantly decreased level of activated caspase-3 and significantly increased levels of X-linked inhibitor of apoptosis protein, which also correlated with increased levels of nuclear factor kappa B p52 and decreased levels of c-Jun N-terminal kinase; this provides a possible mechanism for the decrease in apoptosis seen in CXCR2 knockout mice.
Positive_regulation (increased) of B p52 associated with targeted disruption and apoptosis
1) Confidence 0.22 Published 2010 Journal Hepatology Section Abstract Doc Link 20683965 Disease Relevance 1.40 Pain Relevance 0.49
It is derived from hematopoietic progenitors in the macrophage lineage and differentiates in response to the tumor necrosis factor family cytokine receptor activator of NF kappa B ligand. alpha v beta 3 integrin mediates cell adhesion necessary for polarization and formation of an isolated, acidified resorptive microenvironment.
Positive_regulation (activator) of NF kappa B in macrophage associated with necrosis, cancer, adhesions and cytokine
2) Confidence 0.11 Published 2008 Journal Annual review of pathology Section Abstract Doc Link 18039135 Disease Relevance 0.69 Pain Relevance 0.22
Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma.
Positive_regulation (activator) of NF kappa B associated with osteogenic sarcomas and bone disease
3) Confidence 0.05 Published 2001 Journal Calcif. Tissue Int. Section Title Doc Link 11351498 Disease Relevance 1.86 Pain Relevance 0.09

General Comments

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