INT95668

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Context Info
Confidence 0.47
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 10.14
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
osteoclast 2
juvenile 1
bone marrow 1
myeloid cell 1
adipocytes 1
Tnfrsf11a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 20 99.40 Very High Very High Very High
cytokine 72 95.28 Very High Very High Very High
Pain 12 91.00 High High
Arthritis 91 86.88 High High
rheumatoid arthritis 73 83.60 Quite High
Spinal cord 1 75.84 Quite High
Inflammation 114 72.84 Quite High
addiction 7 70.96 Quite High
Infliximab 1 70.04 Quite High
Etanercept 2 69.44 Quite High
Disease Link Frequency Relevance Heat
Cancer 167 99.02 Very High Very High Very High
Bone Disease 158 98.60 Very High Very High Very High
Hypercalcemia 43 98.30 Very High Very High Very High
Necrosis 7 98.08 Very High Very High Very High
Obesity 14 97.92 Very High Very High Very High
Osteogenic Sarcomas 83 97.80 Very High Very High Very High
Bone Cancer 13 96.86 Very High Very High Very High
Solid Tumor 2 94.24 High High
Disease 96 93.84 High High
Metastasis 71 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Denosumab interferes with RANK signalling by blocking RANKL and, just like OPG, preventing RANK activation.
Positive_regulation (activation) of RANK
1) Confidence 0.47 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2374958 Disease Relevance 1.16 Pain Relevance 0.04
To what extent these discrepancies represent differences in experimental protocols and perhaps the artificial effect of protein over-expression remains to be seen, but clearly further studies are required to precisely clarify the effects of p62 (and indeed RANK) mutations on NF-?
Positive_regulation (indeed) of RANK
2) Confidence 0.46 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.38 Pain Relevance 0.05
Whilst RANK and OPG clearly function as upstream components of this signalling pathway, it is presently unclear as to the role(s) played by VCP in osteoclast NF-?
Positive_regulation (Whilst) of RANK in osteoclast
3) Confidence 0.46 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.13 Pain Relevance 0.04
Secondly, as OPG is a negative regulator of RANK signalling, loss of OPG wild-type function in juvenile hyperphosphatasia is also predicted to promote RANK-NF-?
Positive_regulation (promote) of RANK in juvenile
4) Confidence 0.46 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.79 Pain Relevance 0
RANK (receptor activator of NF?
Positive_regulation (activator) of RANK
5) Confidence 0.42 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129996 Disease Relevance 0.72 Pain Relevance 0.33
When RANK is activated, it sends signals into the cells through tumor necrosis factor receptor-associated factors (TRAFs), mainly TRAF6.
Positive_regulation (activated) of RANK associated with necrosis and cancer
6) Confidence 0.21 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1308846 Disease Relevance 0.79 Pain Relevance 0.10
Also, myeloid cell–specific genes including CD11b, RANK, and DAP12 are reduced in the MDL-1–Ig fusion group and elevated in anti–MDL-1 agonist group.
Positive_regulation (elevated) of RANK in myeloid cell associated with agonist
7) Confidence 0.21 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2839155 Disease Relevance 0.43 Pain Relevance 0.30
OPG-L is the pivotal mediator of osteoclast differentiation and activation; it triggers the cells through RANK (receptor activator of NF-?
Positive_regulation (activator) of RANK in osteoclast
8) Confidence 0.18 Published 2001 Journal Arthritis Res Section Body Doc Link PMC128880 Disease Relevance 0.56 Pain Relevance 0.28
In another hand, adipocytes highly express Adiponectin (also designed as adipose most abundant gene transcript) which was shown to stimulate Receptor Activator of NF-?
Positive_regulation (stimulate) of Receptor Activator in adipocytes associated with obesity
9) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882323 Disease Relevance 1.21 Pain Relevance 0.03
Bone tumors are related to the existence of a vicious cycle between bone resorption and tumor proliferation in which the molecular triad osteoprotegerin (OPG)/receptor activator of NF-kappaB (RANK)/RANK ligand (RANKL) plays a pivotal role.
Positive_regulation (activator) of RANK associated with cancer, hypercalcemia and bone cancer
10) Confidence 0.08 Published 2010 Journal Biochim. Biophys. Acta Section Abstract Doc Link 19733222 Disease Relevance 0.98 Pain Relevance 0.09
However, we observed that incubation of bone marrow cells in vitro with autotaxin-containing tumor cell conditioned media or recombinant autotaxin enhanced M-CSF/RANK-L induced differentiation of mature osteoclasts, indicating that through its lysoPLD activity autotaxin might also control directly osteoclastogenesis.
Positive_regulation (enhanced) of RANK-L in bone marrow associated with cancer
11) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2840030 Disease Relevance 1.11 Pain Relevance 0
Mutation screening of the TNFRSF11A gene encoding receptor activator of NF kappa B (RANK) in familial and sporadic Paget's disease of bone and osteosarcoma.
Positive_regulation (activator) of RANK associated with osteogenic sarcomas and bone disease
12) Confidence 0.04 Published 2001 Journal Calcif. Tissue Int. Section Title Doc Link 11351498 Disease Relevance 1.87 Pain Relevance 0.09

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