INT95669

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 2001
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 10.01
Pain Relevance 0.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF11A) cell-cell signaling (TNFRSF11A)
Anatomy Link Frequency
blood 1
skeleton 1
neutrophils 1
PBMC 1
TNFRSF11A (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 2 98.52 Very High Very High Very High
Angina 3 97.48 Very High Very High Very High
Pain 7 97.24 Very High Very High Very High
cytokine 18 91.16 High High
rheumatoid arthritis 58 68.24 Quite High
Inflammation 31 5.00 Very Low Very Low Very Low
Osteoarthritis 10 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 1 100.00 Very High Very High Very High
Hypercalcemia 12 99.84 Very High Very High Very High
Metastasis 96 99.60 Very High Very High Very High
Osteolysis 21 99.40 Very High Very High Very High
Solid Tumor 2 99.16 Very High Very High Very High
Osteogenic Sarcomas 10 99.00 Very High Very High Very High
Multiple Myeloma 6 99.00 Very High Very High Very High
Spinal Cord Compression 2 99.00 Very High Very High Very High
Cancer 101 98.94 Very High Very High Very High
Pagets Disease 1 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeting RANK/RANKL in the treatment of solid tumours and myeloma.
Regulation (Targeting) of RANK/RANKL associated with solid tumor
1) Confidence 0.56 Published 2010 Journal Curr. Pharm. Des. Section Title Doc Link 20166980 Disease Relevance 1.33 Pain Relevance 0.08
, neutrophils expressed OPG with no change of RANK-L.
Neg (no) Regulation (change) of RANK in neutrophils
2) Confidence 0.44 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906801 Disease Relevance 0.19 Pain Relevance 0.14
OBJECTIVES: The purpose of this study was to investigate the effect of circulating levels of oxidized low-density lipoprotein (ox-LDL) on nuclear factor-kappa B (NF-kB) activation in peripheral blood mononuclear cells (PBMC) of patients with unstable angina (UA) or stable angina (SA) and control subjects.
Spec (investigate) Regulation (effect) of NF-kB in PBMC associated with angina
3) Confidence 0.41 Published 2005 Journal J. Am. Coll. Cardiol. Section Abstract Doc Link 16139128 Disease Relevance 0.27 Pain Relevance 0.27
In these cancers that affect the skeleton in this way the abnormally regulated RANK/RANKL system appears to be the final effector pathway.
Regulation (regulated) of RANK/RANKL in skeleton associated with cancer
4) Confidence 0.41 Published 2010 Journal Curr. Pharm. Des. Section Abstract Doc Link 20166980 Disease Relevance 1.26 Pain Relevance 0.09
Early-onset familial Paget disease of bone (EoPDB) is a rare condition caused by a 27-bp insertion mutation affecting the signal peptide of TNFRSF11A, which encodes RANK.
Regulation (affecting) of TNFRSF11A associated with pagets disease
5) Confidence 0.35 Published 2008 Journal Calcif. Tissue Int. Section Abstract Doc Link 18836673 Disease Relevance 0.27 Pain Relevance 0
In another study, conducted in the same animal model, exogenous RANK-Fc administration was effective at preventing osteolysis and reducing tumor volume in mixed osteolytic and osteoblastic bone lesions [45].
Regulation (effective) of RANK-Fc associated with cancer, osteoporosis and osteolysis
6) Confidence 0.34 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1924520 Disease Relevance 1.51 Pain Relevance 0.03
No specific abnormalities of the TNFRSF11A gene were identified in a Pagetic osteosarcoma, the osteosarcoma cell lines, DNA extracted from Pagetic bone lesions, or DNA extracted from peripheral blood in patients with familial or sporadic Paget's disease including several individuals with early onset Paget's disease.
Neg (No) Regulation (abnormalities) of TNFRSF11A in blood associated with congenital anomalies, disease and osteogenic sarcomas
7) Confidence 0.25 Published 2001 Journal Calcif. Tissue Int. Section Abstract Doc Link 11351498 Disease Relevance 2.24 Pain Relevance 0.05
Three proteins, RANKL, RANK, and OPG have been recently identified as key determinants of osteoclastogenesis and the regulation of bone resorption.
Spec (determinants) Regulation (regulation) of RANK associated with hypercalcemia
8) Confidence 0.06 Published 2008 Journal Cancer Treat. Rev. Section Abstract Doc Link 17964729 Disease Relevance 1.47 Pain Relevance 0.15
RANK ligand as a therapeutic target for bone metastases and multiple myeloma.
Regulation (target) of RANK associated with multiple myeloma and metastasis
9) Confidence 0.04 Published 2008 Journal Cancer Treat. Rev. Section Title Doc Link 17964729 Disease Relevance 1.47 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox