INT95670

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Context Info
Confidence 0.60
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 5.59
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

PDB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 1 95.28 Very High Very High Very High
Pain 11 94.68 High High
rheumatoid arthritis 4 94.04 High High
Analgesic 1 69.44 Quite High
cINOD 1 68.32 Quite High
Nerve growth factor 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bone Disease 115 100.00 Very High Very High Very High
Osteolysis 8 99.96 Very High Very High Very High
Disease 46 98.76 Very High Very High Very High
Nerve Compression Syndromes 1 98.56 Very High Very High Very High
Osteogenic Sarcomas 16 98.08 Very High Very High Very High
Deafness 3 97.24 Very High Very High Very High
Spontaneous Fractures 4 96.20 Very High Very High Very High
Syndrome 19 95.36 Very High Very High Very High
Osteoarthritis 1 95.28 Very High Very High Very High
Pain 9 94.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Loss of heterozygosity (LOH) affecting the PDB/FEO critical region has also been described in osteosarcomas suggesting that TNFRSF11A might also be involved in the development of osteosarcoma.
Regulation (affecting) of PDB associated with osteolysis, osteogenic sarcomas and bone disease
1) Confidence 0.60 Published 2001 Journal Calcif. Tissue Int. Section Abstract Doc Link 11351498 Disease Relevance 2.30 Pain Relevance 0.07
Bisphosphonates are widely regarded as the treatment of choice for Paget's disease of bone (PDB) because of their potent inhibitory effects on bone turnover, but the effects of bisphosphonate therapy on symptoms and complications of PDB have been little studied.
Regulation (effects) of PDB associated with bone disease
2) Confidence 0.27 Published 2010 Journal J. Bone Miner. Res. Section Abstract Doc Link 19580457 Disease Relevance 0.60 Pain Relevance 0.21
Genetic factors play an important role in PDB and mutations or polymorphisms have been identified in four genes that cause classical Paget's disease and related syndromes.
Regulation (role) of PDB associated with syndrome and disease
3) Confidence 0.04 Published 2008 Journal Bone Section Abstract Doc Link 18672105 Disease Relevance 1.04 Pain Relevance 0.14
PDB mutations do not, however, appear to affect p62 protein half-life [22], suggesting that their mechanism of action is unlikely to involve altered protein turnover and expression levels.
Regulation (affect) of PDB associated with bone disease
4) Confidence 0.04 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 0.37 Pain Relevance 0
This article focuses on the role of ubiquitin and the ubiquitin proteasome system (UPS) in the latter condition, PDB [MIM 167250, 602080], which is common in Caucasian populations, affecting up to 3% of individuals aged over 55 years [1].
Regulation (affecting) of PDB associated with bone disease
5) Confidence 0.02 Published 2007 Journal BMC Biochem Section Body Doc Link PMC2106369 Disease Relevance 1.29 Pain Relevance 0.12

General Comments

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