INT9569

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 0.84
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv3)
Anatomy Link Frequency
neurons 1
brain 1
Trpv3 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 98.42 Very High Very High Very High
Inflammation 2 98.42 Very High Very High Very High
agonist 11 97.92 Very High Very High Very High
Potency 3 97.60 Very High Very High Very High
antinociception 5 96.64 Very High Very High Very High
opioid receptor 1 92.80 High High
Antinociceptive 2 90.96 High High
qutenza 13 88.48 High High
Thermal hyperalgesia 1 86.84 High High
nociceptor 5 85.68 High High
Disease Link Frequency Relevance Heat
Pain 5 93.84 High High
INFLAMMATION 1 87.48 High High
Hyperalgesia 1 86.84 High High
Ganglion Cysts 81 85.28 High High
Acidosis 1 79.60 Quite High
Hypothermia 1 68.00 Quite High
Inflammatory Pain 1 52.00 Quite High
Targeted Disruption 1 25.00 Low Low
Death 4 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results are also agreement with that DS-Nh mice having TRPV3 gain-of-function mutation exhibited higher Ca2+ influx upon thermal stimulation in the epidermal sheet preparation [20, 30].
Negative_regulation (exhibited) of TRPV3
1) Confidence 0.40 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2745623 Disease Relevance 0.24 Pain Relevance 0.25
Indeed, mice lacking TRPV3 or TRPV4 have been reported to exhibit abnormal thermo-related behaviors [25, 28].
Negative_regulation (lacking) of TRPV3
2) Confidence 0.40 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2745623 Disease Relevance 0 Pain Relevance 0.26
However, mice deficient of TRPV2 and TRPV1 or TRPV3 or TRPV4 show no major impairment of noxious heat sensing.
Negative_regulation (deficient) of TRPV3
3) Confidence 0.33 Published 2009 Journal Exp Brain Res Section Abstract Doc Link 19404626 Disease Relevance 0.41 Pain Relevance 0.76
We recently reported that H-Lys psi (CH2NH)Lys-Pro-Tyr-Ile-Leu-OH (JMV 449), a pseudopeptide analogue of neurotensin-(8-13) with a reduced CH2NH bond in position 8-9, was about 3 times more potent than neurotensin in binding to mouse brain membranes and in contracting the guinea-pig ileum, and was markedly more resistant to degradation than neurotensin when exposed to rat brain membranes.
Negative_regulation (reduced) of CH2NH in brain
4) Confidence 0.02 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1425958 Disease Relevance 0.07 Pain Relevance 0.20
Atropine and hexamethonium decreased the effect of NH3, indicating that part of the response was mediated by cholinergic effector neurons, but a noncholinergic effect clearly remained.
Negative_regulation (decreased) of NH3 in neurons
5) Confidence 0.00 Published 1987 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3579009 Disease Relevance 0 Pain Relevance 0.51
Estimates of NH3 and N2O losses during housing and storage were derived from the difference between the total amount of TAN in excreta deposited in and around buildings, and the total amount of TAN in manure (i.e. the excreta deposited in and around buildings after collection and storage) prior to spreading and were ca. 64-88 x 10(3) t.
Negative_regulation (losses) of NH3
6) Confidence 0.00 Published 2001 Journal Environ. Pollut. Section Abstract Doc Link 11202744 Disease Relevance 0.07 Pain Relevance 0.07
Endomorphin 1[psi] and endomorphin 2[psi], endomorphins analogues containing a reduced (CH2NH) amide bond between Tyr1 and Pro2, display partial agonist potency but significant antinociception.
Negative_regulation (reduced) of CH2NH associated with antinociception, inflammation, agonist and potency
7) Confidence 0.00 Published 2005 Journal Life Sci. Section Title Doc Link 15878600 Disease Relevance 0.05 Pain Relevance 0.99

General Comments

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