INT95692

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Context Info
Confidence 0.24
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.07
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

KRT19 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 18 99.18 Very High Very High Very High
agonist 17 91.96 High High
Pain 1 84.28 Quite High
withdrawal 2 77.40 Quite High
Bile 3 63.76 Quite High
cytokine 1 54.24 Quite High
abdominal pain 1 50.68 Quite High
Crohn's disease 1 50.08 Quite High
medulla 7 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 187 99.88 Very High Very High Very High
Frailty 1 99.40 Very High Very High Very High
INFLAMMATION 16 99.18 Very High Very High Very High
Breast Cancer 39 99.10 Very High Very High Very High
Injury 12 98.76 Very High Very High Very High
Carcinoma 26 95.80 Very High Very High Very High
Adenocarcinoma 48 92.48 High High
Infarction 1 89.44 High High
Colon Cancer 24 87.80 High High
Epstein-barr Virus 2 85.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon various types of injury such as inflammation or atrophy these cells may additionally switch on K7 and K19, sometimes also K17 (as well as vimentin) and thus express four to five instead of two keratins (Moll et al. 1991).
Negative_regulation (switch) of K19 associated with inflammation, frailty and injury
1) Confidence 0.24 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386534 Disease Relevance 0.45 Pain Relevance 0.05
Immunohistochemical study revealed that both tumors were immunoreactive with AE1/AE3, cytokeratin 7, and cytokeratin 19 but negative for carcinoembryonic antigen and cytokeratin 20.
Negative_regulation (immunoreactive) of cytokeratin 19 associated with cancer
2) Confidence 0.18 Published 2001 Journal Mod. Pathol. Section Abstract Doc Link 11353065 Disease Relevance 0.93 Pain Relevance 0.12
resulting in the inhibition of cell proliferation, suppression of keratin 19,
Negative_regulation (suppression) of keratin 19
3) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2605846 Disease Relevance 1.51 Pain Relevance 0.25
Immuno-histochemistry indicated a primary breast tumour as the cells were strongly positive for ER, positive for CK19 and EMA and negative for TTF1, CK20, WT1, CK7, Ca19.9 and Ca125.
Negative_regulation (positive) of CK19 associated with breast cancer
4) Confidence 0.04 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2694193 Disease Relevance 1.18 Pain Relevance 0.08

General Comments

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