INT95693

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.46
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC4A1) transmembrane transport (SLC4A1)
SLC4A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 2 94.08 High High
Potency 2 88.80 High High
Pain 1 84.28 Quite High
Inflammation 1 76.00 Quite High
backache 2 49.00 Quite Low
Spinal cord 2 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 15 99.88 Very High Very High Very High
Ependymoma 37 98.72 Very High Very High Very High
Carcinoma 16 95.80 Very High Very High Very High
INFLAMMATION 3 93.84 High High
Adenocarcinoma 1 92.48 High High
Chordoma 9 87.24 High High
Pain 1 84.28 Quite High
Epstein-barr Virus 2 82.48 Quite High
Cholangiocarcinoma 2 77.64 Quite High
Recurrence 2 70.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical study revealed that both tumors were immunoreactive with AE1/AE3, cytokeratin 7, and cytokeratin 19 but negative for carcinoembryonic antigen and cytokeratin 20.
Negative_regulation (immunoreactive) of AE1 associated with cancer
1) Confidence 0.41 Published 2001 Journal Mod. Pathol. Section Abstract Doc Link 11353065 Disease Relevance 0.92 Pain Relevance 0.12
Both our cases were positive for CAM5.2, AE1AE3, EMA and CK7 but negative for CK20.
Negative_regulation (positive) of AE1
2) Confidence 0.41 Published 2008 Journal Diagn Pathol Section Body Doc Link PMC2584038 Disease Relevance 1.37 Pain Relevance 0
In Cl-/HCO3- exchange assays, which depend on functional CA to produce transport substrate, 40 microM celecoxib inhibited AE1 by 62+/-4%.
Negative_regulation (inhibited) of AE1
3) Confidence 0.37 Published 2004 Journal Mol. Membr. Biol. Section Abstract Doc Link 15764372 Disease Relevance 0.08 Pain Relevance 0.12
Celecoxib and four of the novel compounds significantly inhibited AE1 Cl-/NO3- exchange activity with EC50 values in the range 0.22-2.8 microM.
Negative_regulation (inhibited) of AE1
4) Confidence 0.37 Published 2004 Journal Mol. Membr. Biol. Section Abstract Doc Link 15764372 Disease Relevance 0.09 Pain Relevance 0.14

General Comments

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