INT95694

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Context Info
Confidence 0.36
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 11
Disease Relevance 4.27
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrnb1) transport (Chrnb1) plasma membrane (Chrnb1)
neurological system process (Chrnb1)
Anatomy Link Frequency
neuronal 3
4T1 1
fibroblast 1
muscle fiber 1
Chrnb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuronal nitric oxide synthase 2 100.00 Very High Very High Very High
cytokine 37 99.92 Very High Very High Very High
agonist 7 99.36 Very High Very High Very High
Nicotine 5 97.32 Very High Very High Very High
Antinociceptive 2 86.80 High High
Analgesic 5 81.12 Quite High
lidocaine 1 79.52 Quite High
fibrosis 1 70.80 Quite High
Inflammation 24 67.92 Quite High
antinociception 2 64.56 Quite High
Disease Link Frequency Relevance Heat
Benign Prostatic Hypertrophy 115 100.00 Very High Very High Very High
Prostate Cancer 45 100.00 Very High Very High Very High
Myasthenia Gravis 3 98.72 Very High Very High Very High
Neurodegenerative Disease 22 96.76 Very High Very High Very High
Disease 105 88.84 High High
Muscle Weakness 2 86.36 High High
Autoimmune Disease 8 84.80 Quite High
Toxicity 1 73.20 Quite High
Prion Diseases 96 71.96 Quite High
Pulmonary Fibrosis 1 71.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Like (-)-nicotine and carbachol, they all act as full agonists in the (86)rubidium ion efflux experiment with intact mouse fibroblast M10 cells stably expressing the alpha 4 beta 2 nicotinic AChR.
Gene_expression (expressing) of AChR in fibroblast associated with nicotine and agonist
1) Confidence 0.36 Published 2001 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 11708903 Disease Relevance 0.07 Pain Relevance 0.85
Those expressed extracellularly and with an average expression level at least three-fold greater in BPH RNA pools than in the prostate cancer RNA pools included: CDH13, CHRNB1, COL4A5, EFEMP2, EMP3, F10 (16-fold), FGF2, FGFBP1 (10-fold), IGF1, IGF2 (18-fold), LIPG, RARB, SGCA, SGCD, TGFB1, TGFB3 (14-fold), TGFBR2 and TIMP2 of the “high in BPH, moderate in prostate cancer” group; SMOC1 (26-fold) in the “high in BPH, low in prostate cancer” group; and SCGB3A1 (15-fold) and SCGB1A1 (14-fold) in the “moderate in BPH, low in prostate cancer” group.


Gene_expression (expressed) of CHRNB1 associated with benign prostatic hypertrophy and prostate cancer
2) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793011 Disease Relevance 2.44 Pain Relevance 0
We investigated whether the changes in acetylcholine receptor (AChR) distribution and neuronal nitric oxide synthase (nNOS) expression reported for the skeletal muscle of mdx mice were a consequence of muscle fiber regeneration rather than of the absence of dystrophin.
Gene_expression (expression) of AChR in muscle fiber associated with neuronal nitric oxide synthase
3) Confidence 0.17 Published 2001 Journal Muscle Nerve Section Abstract Doc Link 11353428 Disease Relevance 0 Pain Relevance 0.17
Most individual AChR ‘spots’ are 3–5 ?
Gene_expression (spots) of AChR
4) Confidence 0.13 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0 Pain Relevance 0
To determine whether RVG-9r could deliver siRNA specifically to AchR-expressing neuronal cells when complexed with liposomes, we exposed LSPCs composed of either DyLight 488-labeled RVG-9r or control RVM-9r peptide and increasing concentrations of liposomes to N2a cells in the presence of 10% fetal bovine serum (FBS).
Gene_expression (expressing) of AchR in neuronal
5) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.19 Pain Relevance 0
Liposome-siRNA-peptide complexes (LSPCs) delivered PrP siRNA specifically to AchR-expressing cells, suppressed PrPC expression and eliminated PrPRES formation in vitro.
Gene_expression (expressing) of AchR
6) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2885418 Disease Relevance 0.15 Pain Relevance 0
RVG-9r LSPCs were delivered to AchR-expressing cells in as little as one hour, with LSPC dissociation and siRNA movement to the perinuclear space by twenty hours after treatment.
Gene_expression (expressing) of AchR
7) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.06 Pain Relevance 0
Both HeLa and 293T cells have been shown to lack AchRs[26], and several microarray analyses have failed to demonstrate AchR expression in 4T1 cells [52], [53], [54], consistent with lack of RVG binding to them.
Gene_expression (expression) of AchR in 4T1
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.07 Pain Relevance 0
We further show that AchR-expressing neuronal cells specifically targeted by RVG-9r LSPCs also express PrPC, which was suppressed 70% by PrP siRNA LSPCs 48 hours after treatment.
Gene_expression (expressing) of AchR in neuronal
9) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.06 Pain Relevance 0
These data validate the use of LSPCs to protect siRNAs from serum degradation and deliver them across the BBB to AchR-expressing neuronal cells throughout the brain to potentially cure prion and perhaps other neurodegenerative diseases.


Gene_expression (expressing) of AchR in neuronal associated with neurodegenerative disease
10) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885418 Disease Relevance 0.16 Pain Relevance 0
By the effect of cytokines on AchR expression they proved the contributions of IFN?
Gene_expression (expression) of AchR associated with cytokine
11) Confidence 0.05 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654796 Disease Relevance 1.06 Pain Relevance 0.31

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