INT95699

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.14
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Gad2) Golgi apparatus (Gad2) plasma membrane (Gad2)
cytoplasm (Gad2)
Anatomy Link Frequency
synaptic vesicles 1
Gad2 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 46 100.00 Very High Very High Very High
imagery 13 98.38 Very High Very High Very High
gABA 68 97.80 Very High Very High Very High
Pyramidal cell 28 90.76 High High
adenocard 2 88.00 High High
agonist 4 59.60 Quite High
Glutamate 34 50.00 Quite Low
Neurotransmitter 12 41.36 Quite Low
excitatory amino acid 2 38.28 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Cerebral Palsy 86 83.60 Quite High
Phobia 2 83.56 Quite High
Spasticity 40 83.48 Quite High
Dyskinesias 2 73.40 Quite High
Epilepsy 20 72.60 Quite High
Neurological Disease 6 71.84 Quite High
Anxiety Disorder 2 70.68 Quite High
Generalized Anxiety Disorder 35 64.72 Quite High
Muscle Rigidity 4 58.16 Quite High
Ceroid Lipofuscinosis 6 50.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The N-terminus of GAD65 is palmitoylated and binds to the cellular membrane.
GAD65 Binding (binds) of
1) Confidence 0.40 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.69 Pain Relevance 0.15
Area of imaging was selected solely on the basis of the YFP channel, hence the experimenter was blind to the GAD65 staining.
GAD65 Binding (blind) of associated with imagery
2) Confidence 0.37 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2686200 Disease Relevance 0 Pain Relevance 0.18
We observed modest evidence of association (P = 0.05) between BI and the glutamic acid decarboxylase gene (65 kDA isoform), which encodes an enzyme involved in GABA synthesis.
glutamic acid decarboxylase gene Binding (association) of associated with gaba
3) Confidence 0.35 Published 2001 Journal Am. J. Med. Genet. Section Abstract Doc Link 11353440 Disease Relevance 0.22 Pain Relevance 0.14
GAD65, an isoform of glutamic acid decarboxylase, is localized to GABAergic presynaptic terminals and physically coupled to synaptic vesicles ([29]).
GAD65 Binding (coupled) of in synaptic vesicles associated with gabaergic
4) Confidence 0.31 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.15
This shift analysis revealed a highly significant 30% decrease in GAD65-GFAP association (p ?
GAD65-GFAP Binding (association) of
5) Confidence 0.31 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2689695 Disease Relevance 0 Pain Relevance 0.09
These N-terminal domains are thought to be responsible for sub-cellular targeting and the formation of GAD65–GAD67 heterodimers [26].
GAD65 Binding (formation) of
6) Confidence 0.30 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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