INT957

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Context Info
Confidence 0.70
First Reported 1978
Last Reported 2010
Negated 5
Speculated 5
Reported most in Abstract
Documents 136
Total Number 141
Disease Relevance 36.84
Pain Relevance 40.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH) extracellular region (GHRH) cell-cell signaling (GHRH)
Anatomy Link Frequency
plasma 29
pituitary 7
cerebrospinal fluid 3
thyroid 3
body 3
GHRH (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 225 100.00 Very High Very High Very High
antagonist 41 100.00 Very High Very High Very High
Catecholamine 18 100.00 Very High Very High Very High
substance P 16 100.00 Very High Very High Very High
opiate 38 99.98 Very High Very High Very High
Sumatriptan 21 99.98 Very High Very High Very High
fluoxetine 97 99.84 Very High Very High Very High
narcan 85 99.84 Very High Very High Very High
dexamethasone 24 99.84 Very High Very High Very High
anesthesia 16 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Growth Hormone Deficiency 12 100.00 Very High Very High Very High
Stress 151 99.98 Very High Very High Very High
Hyperplasia 9 99.90 Very High Very High Very High
Critical Illness 110 99.84 Very High Very High Very High
Hypertension 23 99.84 Very High Very High Very High
Gastric Motility Disorder 17 99.84 Very High Very High Very High
Diabetes Mellitus 94 99.80 Very High Very High Very High
Hypopituitarism 12 99.76 Very High Very High Very High
Thyroid Disease 21 99.72 Very High Very High Very High
Obesity 129 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exploration of the pituitary gland only revealed somatotrophic hyperplasia and his plasma growth hormone (GH) levels remained elevated.
Positive_regulation (elevated) of his plasma growth hormone in plasma associated with hyperplasia
1) Confidence 0.70 Published 1996 Journal Jpn. J. Clin. Oncol. Section Abstract Doc Link 8551667 Disease Relevance 1.34 Pain Relevance 0.06
Persistent elevation of growth hormone promotes hypertrophy of the bones and ligaments, resulting in widening of the thoracolumbar vertebral bodies, and developmental narrowing of the spinal canal.
Positive_regulation (elevation) of growth hormone in spinal associated with hypertrophy
2) Confidence 0.69 Published 1982 Journal J. Neurosurg. Section Abstract Doc Link 7054412 Disease Relevance 0.60 Pain Relevance 0.20
Corticoid-induced growth hormone (GH) secretion in GH-deficient and normal children.
Positive_regulation (induced) of growth hormone
3) Confidence 0.69 Published 1992 Journal J. Clin. Endocrinol. Metab. Section Title Doc Link 1639956 Disease Relevance 0.08 Pain Relevance 0.11
Serum GH levels increased significantly in response to GHRH, clonidine, and moxonidine.
Positive_regulation (increased) of GHRH associated with clonidine
4) Confidence 0.68 Published 1995 Journal Exp. Clin. Endocrinol. Diabetes Section Abstract Doc Link 7584524 Disease Relevance 0 Pain Relevance 0.79
The intravenous (iv) administration of thyrotrophin releasing hormone (TRH, at 1.0 or 10.0 micrograms/kg) or human pancreatic growth hormone-releasing factor (hpGRF(1-44)NH2, at 10 micrograms/kg) markedly increased the growth hormone (GH) concentration in the plasma of immature or adult cockerels anaesthetized by sodium pentabarbitone (30 mg/kg, iv).
Positive_regulation (increased) of growth hormone in plasma
5) Confidence 0.68 Published 1985 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3926599 Disease Relevance 0 Pain Relevance 0
Installation of saline solution containing 10 microM capsaicin produced a significant increase of mean urine output, an increase of GRF, of EPRF and of [Na+] and [K+] urine concentration.
Positive_regulation (increase) of GRF in urine associated with qutenza
6) Confidence 0.67 Published 1995 Journal Scand. J. Urol. Nephrol. Section Abstract Doc Link 7618049 Disease Relevance 0.42 Pain Relevance 0.69
Whereas L-dopa elicited a growth hormone response of similar magnitude in both groups, clonidine infusion induced a significant increase in serum growth hormone in normotensive, but not in hypertensive, subjects. 3.
Positive_regulation (increase) of serum growth hormone associated with hypertension and clonidine
7) Confidence 0.65 Published 1980 Journal Clin. Sci. Section Abstract Doc Link 7357832 Disease Relevance 0.44 Pain Relevance 0.32
Medetomidine had a powerful and dose-dependent effect in reducing noradrenaline (by a maximum of 75%) and increasing human growth hormone levels in plasma.
Positive_regulation (increasing) of growth hormone in plasma associated with noradrenaline
8) Confidence 0.61 Published 1989 Journal Acta Vet Scand Suppl Section Abstract Doc Link 2571265 Disease Relevance 0 Pain Relevance 0.21
However, a mean 59% inhibition of the clonidine-induced peak elevation of plasma growth hormone was observed (p less than 0.05).
Positive_regulation (elevation) of growth hormone in plasma associated with clonidine
9) Confidence 0.60 Published 1989 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2568210 Disease Relevance 0.23 Pain Relevance 0.76
The control subjects had significantly increased plasma growth hormone (GH) levels after GH-RF infusion whereas panic disorder patients did not.
Positive_regulation (increased) of plasma growth hormone in plasma associated with panic disorder
10) Confidence 0.59 Published 1989 Journal Am J Psychiatry Section Abstract Doc Link 2492166 Disease Relevance 0.26 Pain Relevance 0.07
Endogenous and exogenous opiate-like compounds have been found to cause increased serum growth hormone and prolactin levels in animals, and, in some cases, humans.
Positive_regulation (increased) of growth hormone associated with opiate
11) Confidence 0.59 Published 1979 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 116298 Disease Relevance 0 Pain Relevance 0.27
The net increase in GRF and moment of z axis during perturbation in CI group can be attributed to increased COP excursion velocity during postural adjustments response movements in low back pain patients after stability exercises (Figure 2, 3, 4 and 5).
Positive_regulation (increase) of GRF associated with low back pain and backache
12) Confidence 0.58 Published 2010 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2903540 Disease Relevance 0.29 Pain Relevance 0.29
A single oral dose of clonidine (0.15 mg), a selective alpha-adrenergic stimulating agent, was able to increase plasma growth hormone (GH) levels (above 5 ng/ml) in 6 out of 7 normal men tested.
Positive_regulation (increase) of growth hormone in plasma associated with clonidine
13) Confidence 0.57 Published 1979 Journal J. Endocrinol. Invest. Section Abstract Doc Link 119798 Disease Relevance 0.09 Pain Relevance 0.31
Sumatriptan significantly elevated plasma growth hormone but did not alter plasma prolactin.
Neg (not) Positive_regulation (elevated) of growth hormone in plasma associated with sumatriptan
14) Confidence 0.57 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9040124 Disease Relevance 0 Pain Relevance 0.48
Sumatriptan decreases food intake and increases plasma growth hormone in healthy women.
Positive_regulation (increases) of growth hormone in plasma associated with sumatriptan
15) Confidence 0.57 Published 1997 Journal Psychopharmacology (Berl.) Section Title Doc Link 9040124 Disease Relevance 0 Pain Relevance 0.49
Suminiski and associates [10] reported that the ingestion of arginine (1.5 g) and lysine (1.5 g) resulted in a 2.7-fold increase in plasma growth hormone concentrations in resistance trained males.
Positive_regulation (increase) of growth hormone in plasma
16) Confidence 0.55 Published 2004 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129157 Disease Relevance 0 Pain Relevance 0.04
The researchers found that growth hormone concentrations were elevated during a marathon run to a greater degree than exercise would elicit alone.
Positive_regulation (elevated) of growth hormone
17) Confidence 0.55 Published 2004 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129157 Disease Relevance 0 Pain Relevance 0.03
Dermorphin (D) significantly increased plasma growth hormone (GH) concentrations.
Positive_regulation (increased) of plasma growth hormone in plasma
18) Confidence 0.51 Published 1983 Journal Neuroendocrinology Section Abstract Doc Link 6633818 Disease Relevance 0 Pain Relevance 0.30
Both MK-462 and sumatriptan provoked mild increases in serum growth hormone without any effect on serum prolactin concentrations.
Positive_regulation (increases) of serum growth hormone
19) Confidence 0.51 Published 1997 Journal Br J Clin Pharmacol Section Body Doc Link 9056052 Disease Relevance 0 Pain Relevance 0
The stimulatory effect of clonidine and L-dopa on GH release is mediated via GHRH.
Positive_regulation (mediated) of GHRH associated with clonidine
20) Confidence 0.50 Published 1991 Journal Neuroendocrinology Section Abstract Doc Link 1901390 Disease Relevance 0.18 Pain Relevance 0.14

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