INT95726

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Context Info
Confidence 0.45
First Reported 2001
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 8
Disease Relevance 1.43
Pain Relevance 13.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Naa15) cytoplasm (Naa15)
Anatomy Link Frequency
brainstem 10
spinal cord 6
Naa15 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 72 100.00 Very High Very High Very High
Spinal cord 40 100.00 Very High Very High Very High
medulla 40 100.00 Very High Very High Very High
intrathecal 40 98.92 Very High Very High Very High
withdrawal 64 98.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Substance Withdrawal Syndrome 8 97.20 Very High Very High Very High
Opiate Addiction 8 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal injection of nNOS AS-ONs significantly inhibited the increased expression of NMDA1AR mRNA in the spinal cord and brainstem of morphine-withdrawal rats.
Positive_regulation (increased) of Gene_expression (expression) of NMDA1AR mRNA in brainstem associated with medulla, withdrawal, morphine, spinal cord and intrathecal
1) Confidence 0.45 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 11354793 Disease Relevance 0.17 Pain Relevance 1.75
The expression of NMDA1AR mRNA in the spinal cord and brainstem increased in morphine-dependent rats and increased to a greater extent in morphine-withdrawal rats.
Positive_regulation (increased) of Gene_expression (expression) of NMDA1AR mRNA in brainstem associated with medulla, withdrawal, morphine and spinal cord
2) Confidence 0.45 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 11354793 Disease Relevance 0.19 Pain Relevance 1.67
The expression of NMDA1AR mRNA in the spinal cord and brainstem increased in morphine-dependent rats and increased to a greater extent in morphine-withdrawal rats.
Positive_regulation (increased) of Gene_expression (expression) of NMDA1AR mRNA in brainstem associated with medulla, withdrawal, morphine and spinal cord
3) Confidence 0.45 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 11354793 Disease Relevance 0.19 Pain Relevance 1.70
[Intrathecal injection of NOS antisense oligonucleotides inhibits the increase of NMDA1AR mRNA expression in the spinal cord and brainstem of morphine-withdrawal rats].
Positive_regulation (increase) of Gene_expression (expression) of NMDA1AR mRNA in spinal cord associated with medulla, withdrawal, morphine, spinal cord and intrathecal
4) Confidence 0.45 Published 2001 Journal Sheng Li Xue Bao Section Title Doc Link 11354793 Disease Relevance 0.17 Pain Relevance 1.54
The expression of NMDA1AR mRNA in the spinal cord and brainstem increased in morphine-dependent rats and increased to a greater extent in morphine-withdrawal rats.
Positive_regulation (increased) of in spinal cord Gene_expression (expression) of NMDA1AR mRNA in brainstem associated with medulla, withdrawal, morphine and spinal cord
5) Confidence 0.15 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 11354793 Disease Relevance 0.19 Pain Relevance 1.70
Intrathecal injection of nNOS AS-ONs significantly inhibited the increased expression of NMDA1AR mRNA in the spinal cord and brainstem of morphine-withdrawal rats.
Positive_regulation (increased) of in spinal cord Gene_expression (expression) of NMDA1AR mRNA in brainstem associated with medulla, withdrawal, morphine, spinal cord and intrathecal
6) Confidence 0.15 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 11354793 Disease Relevance 0.17 Pain Relevance 1.75
[Intrathecal injection of NOS antisense oligonucleotides inhibits the increase of NMDA1AR mRNA expression in the spinal cord and brainstem of morphine-withdrawal rats].
Positive_regulation (increase) of in brainstem Gene_expression (expression) of NMDA1AR mRNA in spinal cord associated with medulla, withdrawal, morphine, spinal cord and intrathecal
7) Confidence 0.15 Published 2001 Journal Sheng Li Xue Bao Section Title Doc Link 11354793 Disease Relevance 0.17 Pain Relevance 1.54
The expression of NMDA1AR mRNA in the spinal cord and brainstem increased in morphine-dependent rats and increased to a greater extent in morphine-withdrawal rats.
Positive_regulation (increased) of in spinal cord Gene_expression (expression) of NMDA1AR mRNA in brainstem associated with medulla, withdrawal, morphine and spinal cord
8) Confidence 0.15 Published 2001 Journal Sheng Li Xue Bao Section Abstract Doc Link 11354793 Disease Relevance 0.19 Pain Relevance 1.67

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