INT9573

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Context Info
Confidence 0.43
First Reported 1992
Last Reported 2009
Negated 2
Speculated 3
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 6.04
Pain Relevance 8.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Bdkrb2) plasma membrane (Bdkrb2) signal transducer activity (Bdkrb2)
Anatomy Link Frequency
nerve 2
Blood 1
sciatic nerve 1
smooth muscle 1
knee joint 1
Bdkrb2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 198 100.00 Very High Very High Very High
b2 receptor 138 100.00 Very High Very High Very High
antagonist 29 100.00 Very High Very High Very High
intrathecal 3 100.00 Very High Very High Very High
Analgesic 4 99.98 Very High Very High Very High
nociceptor 6 99.64 Very High Very High Very High
agonist 150 99.60 Very High Very High Very High
Pain 3 99.36 Very High Very High Very High
Hyperalgesia 6 99.30 Very High Very High Very High
qutenza 15 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 14 99.76 Very High Very High Very High
Pain 5 99.36 Very High Very High Very High
Increased Venous Pressure Under Development 12 99.32 Very High Very High Very High
Hyperalgesia 9 99.30 Very High Very High Very High
INFLAMMATION 10 99.04 Very High Very High Very High
Disease 1 98.40 Very High Very High Very High
Cancer 200 96.08 Very High Very High Very High
Arthritis 1 95.92 Very High Very High Very High
Nociception 6 95.16 Very High Very High Very High
Asthma 2 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study measured the densities of B1R and B2R binding sites in the spinal cord and dorsal root ganglia (DRG) by quantitative autoradiography, and evaluated the effects of two selective non-peptide antagonists at B1R (LF22-0542) and B2R (LF16-0687) on pain behavior after partial ligation of the left sciatic nerve.
Spec (partial) Regulation (effects) of B2R in sciatic nerve associated with pain, antagonist, sciatic nerve and spinal cord
1) Confidence 0.43 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18182225 Disease Relevance 0.45 Pain Relevance 0.64
Blood half-life of Gd-DTPA as a result of the infusion of bradykinin B2 receptor agonists
Regulation (infusion) of bradykinin B2 in Blood associated with agonist and b2 receptor
2) Confidence 0.40 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.30 Pain Relevance 0.39
The effect of peripheral and intrathecal administration of the bradykinin B2 receptor antagonist HOE140 and the non-steroidal anti-inflammatory drug indomethacin were studied on the response of dorsal horn nociceptive neurones to formalin in the anaesthetized rat.
Regulation (effect) of bradykinin B2 receptor in dorsal horn associated with nociception, inflammation, antagonist, dorsal horn, b2 receptor and intrathecal
3) Confidence 0.40 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1425970 Disease Relevance 0.32 Pain Relevance 0.38
In vitro and in vivo effects of the new nonpeptide bradykinin B2 receptor antagonist, LF 16-0335C, on guinea-pig and rat kinin receptors.
Regulation (effects) of B2 receptor associated with antagonist and b2 receptor
4) Confidence 0.39 Published 1999 Journal Fundam Clin Pharmacol Section Title Doc Link 10027091 Disease Relevance 0.24 Pain Relevance 0.52
We have examined the effect of a tachykinin NK1 and a bradykinin B2 antagonist, and a mu-opioid agonist on plasma extravasation observed in response to two differing nerve stimulating parameters (10 V, 1 ms, 2 Hz and 25 V, 2 ms, 10 Hz).
Spec (examined) Regulation (effect) of bradykinin B2 in nerve associated with mu agonist, antagonist and bradykinin
5) Confidence 0.38 Published 1998 Journal Neurosci. Lett. Section Abstract Doc Link 9857952 Disease Relevance 0.39 Pain Relevance 0.57
The bradykinin B2 receptor antagonist Hoe 140 affected neither PNV- nor capsaicin-induced responses.
Neg (neither) Regulation (affected) of bradykinin B2 receptor associated with qutenza, antagonist and b2 receptor
6) Confidence 0.25 Published 2001 Journal Life Sci. Section Abstract Doc Link 11554618 Disease Relevance 0.72 Pain Relevance 1.10
Bradykinin B2 receptor agonists are vasodilator peptides that act on the G-protein coupled bradykinin B2 receptors expressed on the endothelial and smooth muscle cells of the microvasculature supplying most tissues and organs[10,11].
Regulation (act) of bradykinin B2 in smooth muscle cells associated with agonist, b2 receptor and bradykinin
7) Confidence 0.24 Published 2009 Journal J Transl Med Section Body Doc Link PMC2689161 Disease Relevance 0.98 Pain Relevance 0.33
These findings support the hypothesis that acid-induced and afferent nerve-mediated mesenteric hyperemia is modulated by a mechanism that involves bradykinin B2 receptor.
Regulation (involves) of bradykinin B2 receptor in nerve associated with b2 receptor and increased venous pressure under development
8) Confidence 0.23 Published 2002 Journal Life Sci. Section Abstract Doc Link 11837250 Disease Relevance 0.68 Pain Relevance 0.65
This depended on the B2 receptor, PLC activation, and inositol triphosphate-mediated Ca2+ release.
Regulation (depended) of B2 receptor associated with b2 receptor
9) Confidence 0.16 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485565 Disease Relevance 0.38 Pain Relevance 0.67
The Randall-Selitto paradigm (maximal tolerated pressure externally applied by a mechanical device) was used to develop a rat model of localized inflammatory hyperalgesia in order to compare the analgesic effects of bradykinin (BK) B1 and B2 receptor antagonists and of a non-steroidal anti-inflammatory drug (NSAID).
Regulation (effects) of B2 receptor associated with hyperalgesia, inflammation, antagonist, analgesic, cinod, b2 receptor and bradykinin
10) Confidence 0.14 Published 2000 Journal Immunopharmacology Section Abstract Doc Link 10647872 Disease Relevance 0.68 Pain Relevance 1.00
This increase was sensitive to calcineurin and B2 receptor inhibition.
Regulation (sensitive) of B2 receptor associated with b2 receptor
11) Confidence 0.07 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17485565 Disease Relevance 0.14 Pain Relevance 0.55
In the present study, we examined the effects of a novel, potent, selective, and orally active nonpeptide bradykinin B2 receptor antagonist, FR167344 (N-[N-[3-[(3-bromo-2-methylimidazo[1,2-a]pyridin-8-yl)oxymethyl]-2 ,4-dichlorophenyl]-N-methylaminocarbonylmethyl]-4-(dimethylamin ocarbonyl)cinnamylamide hydrochloride), on guinea-pig tracheal smooth muscle bradykinin receptors.
Spec (examined) Regulation (effects) of B2 receptor in smooth muscle associated with antagonist, b2 receptor and bradykinin
12) Confidence 0.06 Published 1998 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 10100888 Disease Relevance 0.28 Pain Relevance 0.60
Bradykinin B1 and B2 receptor antagonists do not change the ongoing activity of slowly conducting articular afferents in the inflamed knee joint of the cat.
Neg (not) Regulation (change) of B2 receptor in knee joint associated with antagonist, b2 receptor and bradykinin
13) Confidence 0.02 Published 1993 Journal Neurosci. Lett. Section Title Doc Link 8152602 Disease Relevance 0.47 Pain Relevance 1.02

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