INT95730

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Context Info
Confidence 0.19
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 5.65
Pain Relevance 4.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CP, SPINK1) extracellular space (CP) oxidoreductase activity (CP)
transmembrane transport (CP)
CP (Homo sapiens)
SPINK1 (Homo sapiens)
SPINK1 - N34S (6)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 435 100.00 Very High Very High Very High
medulla 6 97.40 Very High Very High Very High
alcohol 72 96.04 Very High Very High Very High
fibrosis 73 94.16 High High
Inflammation 25 85.88 High High
Inflammatory response 6 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 579 100.00 Very High Very High Very High
Fibrosis 66 94.16 High High
Nicotine Addiction 6 92.16 High High
Injury 42 91.64 High High
Cystic Fibrosis 7 91.44 High High
Disease 7 89.16 High High
INFLAMMATION 31 85.88 High High
Primary Sclerosing Cholangitis 30 74.68 Quite High
Pancreatic Cancer 12 68.92 Quite High
Syndrome 24 48.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients with idiopathic CP had a significant association with the SPINK1 N34S polymorphism as evidenced by a pooled OR of 14.66.
CP Binding (association) of SPINK1 (N34S) associated with chronic pancreatitis
1) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.85 Pain Relevance 0.52
The risk of familial and hereditary CP is strongly associated with SPINK1 N34S, but these data should be interpreted with caution.
CP Binding (associated) of SPINK1 (N34S) associated with chronic pancreatitis
2) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.99 Pain Relevance 0.64
We tested the hypothesis that the true effect size of the functional SPINK1 N34S haplotype is pathway-dependent by reviewing the world literature and gathering data from case-control studies that evaluated the association of SPINK1 N34S with CP.
CP Binding (association) of SPINK1 (N34S) associated with chronic pancreatitis
3) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.83 Pain Relevance 0.44
The association of SPINK1 N34S with the risk of alcoholic CP was significant, but the lowest of the subgroups.
CP Binding (association) of SPINK1 (N34S) associated with chronic pancreatitis
4) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.59 Pain Relevance 0.45
We found that SPINK1 N34S is strongly associated with CP overall (OR 11.00; 95% CI: 7.59–15.93), but the effect of SPINK1 N34S in alcoholic CP (OR 4.98, 95% CI: 3.16–7.85) was significantly smaller than in idiopathic CP (OR 14.97, 95% C.I.?
CP Binding (associated) of SPINK1 (N34S) associated with chronic pancreatitis
5) Confidence 0.14 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2289874 Disease Relevance 1.14 Pain Relevance 0.90
For each study, we initially evaluated the association of SPINK1 N34S high-risk haplotype with CP separately.
CP Binding (association) of SPINK1 (N34S) associated with chronic pancreatitis
6) Confidence 0.14 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289874 Disease Relevance 0.27 Pain Relevance 0.27
Recently, the N34S alteration of the pancreatic secretory trypsin inhibitor (PSTI) gene has been suggested to be closely associated with the pathogenesis of hereditary and/or idiopathic CP.
CP Binding (associated) of PSTI associated with chronic pancreatitis
7) Confidence 0.12 Published 2001 Journal J. Hum. Genet. Section Abstract Doc Link 11355022 Disease Relevance 0.97 Pain Relevance 0.80

General Comments

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