INT95738

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Context Info
Confidence 0.70
First Reported 2001
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 40
Total Number 42
Disease Relevance 23.46
Pain Relevance 13.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
liver 8
spinal cord 6
spinal 4
neurons 4
astrocytes 4
Mapk8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 33 100.00 Very High Very High Very High
dorsal root ganglion 22 100.00 Very High Very High Very High
Paracetamol 16 99.98 Very High Very High Very High
cva 15 99.98 Very High Very High Very High
tolerance 64 99.84 Very High Very High Very High
noradrenaline 22 99.82 Very High Very High Very High
Nerve growth factor 10 99.76 Very High Very High Very High
Sciatic nerve 14 99.64 Very High Very High Very High
Morphine 9 99.64 Very High Very High Very High
Thermal hyperalgesia 9 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 160 100.00 Very High Very High Very High
Ganglion Cysts 24 100.00 Very High Very High Very High
Hemorrhage 14 99.98 Very High Very High Very High
Nervous System Injury 7 99.90 Very High Very High Very High
Diabetes Mellitus 110 99.84 Very High Very High Very High
Poisoning 29 99.54 Very High Very High Very High
Hyperalgesia 43 99.52 Very High Very High Very High
Diabetic Neuropathy 52 99.38 Very High Very High Very High
Neuropathic Pain 17 99.36 Very High Very High Very High
Apoptosis 216 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subcutaneous bee venom (BV)-induced persistent pain stimulation resulted in a significant increase in the phosphorylation of both JNK isoforms in each area for a long period (lasting at least 48 h).
Positive_regulation (crease i) of Phosphorylation (osphorylation o) of JNK associated with pain and lasting pain
1) Confidence 0.70 Published 2007 Journal Neurosci. Lett. Section Abstract Doc Link 17923323 Disease Relevance 0.30 Pain Relevance 0.54
An i.pl. injection of nerve growth factor (NGF) also induced the phosphorylation of JNK as well as thermal hyperalgesia, and SP600125 improved hyperalgesia.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK in nerve associated with hyperalgesia, nerve growth factor and thermal hyperalgesia
2) Confidence 0.69 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16055088 Disease Relevance 1.31 Pain Relevance 1.02
Additionally, KA increased the phosphorylation of JNK, especially JNK1, which was attenuated by CHX.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of JNK
3) Confidence 0.64 Published 2001 Journal Mol. Cells Section Abstract Doc Link 11355693 Disease Relevance 0 Pain Relevance 0.27
G. elata resulted in phosphorylation and dephosphorylation of ERK1/2 and JNK1/2-p38 MAPKs (members of the serine/threonine kinase family), respectively, as revealed by Western blot analysis.
Positive_regulation (resulted) of Phosphorylation (phosphorylation) of JNK
4) Confidence 0.49 Published 2004 Journal Life Sci. Section Abstract Doc Link 15261768 Disease Relevance 0.77 Pain Relevance 0.09
G. elata resulted in phosphorylation and dephosphorylation of ERK1/2 and JNK1/2-p38 MAPKs (members of the serine/threonine kinase family), respectively, as revealed by Western blot analysis.
Positive_regulation (resulted) of Phosphorylation (dephosphorylation) of JNK
5) Confidence 0.49 Published 2004 Journal Life Sci. Section Abstract Doc Link 15261768 Disease Relevance 0.77 Pain Relevance 0.09
The induction of tolerance by SLH leads to phosphorylation of both p44/42 and SAPK/JNK MAP-kinases.
Positive_regulation (leads) of Phosphorylation (phosphorylation) of JNK associated with tolerance and cva
6) Confidence 0.49 Published 2002 Journal Shock Section Abstract Doc Link 12166775 Disease Relevance 0.85 Pain Relevance 0.65
CONCLUSIONS/INTERPRETATION: Fidarestat-sensitive phosphorylation of JNK and c-Jun occurs in fast-conduction mechanoceptors-the same class of neurones that registers the changes in sensory nerve conduction velocity-and in nociceptors.
Positive_regulation (occurs) of Phosphorylation (phosphorylation) of JNK in nociceptors
7) Confidence 0.45 Published 2006 Journal Diabetologia Section Body Doc Link 16456679 Disease Relevance 0 Pain Relevance 0
Moreover, PSNL increased the phosphorylation of mitogen activated protein (MAP) kinases, including the extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), but not p38, in glia-like cells in these same areas.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of JNK
8) Confidence 0.44 Published 2002 Journal Pain Section Abstract Doc Link 12237195 Disease Relevance 0.33 Pain Relevance 0.57
Moreover, PSNL increased the phosphorylation of mitogen activated protein (MAP) kinases, including the extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK), but not p38, in glia-like cells in these same areas.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of c-Jun N-terminal kinase
9) Confidence 0.44 Published 2002 Journal Pain Section Abstract Doc Link 12237195 Disease Relevance 0.33 Pain Relevance 0.57
Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of c-Jun N-terminal kinase in astrocytes associated with spinal dorsal horn and sciatic nerve
10) Confidence 0.44 Published 2002 Journal Pain Section Title Doc Link 12237195 Disease Relevance 0.35 Pain Relevance 0.51
Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of JNK in astrocytes associated with spinal dorsal horn and sciatic nerve
11) Confidence 0.44 Published 2002 Journal Pain Section Title Doc Link 12237195 Disease Relevance 0.35 Pain Relevance 0.51
To elucidate the involvement of the noradrenergic system in the regulation of spinal microglial activity, we examined the effects of noradrenaline (NA) on the phosphorylation of three MAP kinases (extracellular signal-regulated kinase (ERK), p38, or c-Jun N-terminal kinase (JNK)) stimulated by ATP in rat cultured spinal microglia using Western blotting.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of c-Jun N-terminal kinase in spinal associated with noradrenaline
12) Confidence 0.41 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0 Pain Relevance 0.27
To elucidate the involvement of the noradrenergic system in the regulation of spinal microglial activity, we examined the effects of noradrenaline (NA) on the phosphorylation of three MAP kinases (extracellular signal-regulated kinase (ERK), p38, or c-Jun N-terminal kinase (JNK)) stimulated by ATP in rat cultured spinal microglia using Western blotting.
Positive_regulation (stimulated) of Phosphorylation (phosphorylation) of JNK in spinal associated with noradrenaline
13) Confidence 0.41 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19524113 Disease Relevance 0 Pain Relevance 0.27
JNK phosphorylation in liver, muscle and adipose tissue were increased in septic animals and atorvastatin induced a downmodulation in the phosphorylation of this serine kinase (Fig. 4A–C).
Positive_regulation (increased) of Phosphorylation (phosphorylation) of JNK in liver associated with obesity
14) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.75 Pain Relevance 0.07
Our data showing that atorvastatin inhibits JNK phosphorylation/activation in septic rats indicate that the beneficial effect of this drug in improving survival and reducing insulin resistance is mediated by different pathways.
Positive_regulation (activation) of Phosphorylation (phosphorylation) of JNK associated with insulin resistance
15) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 1.22 Pain Relevance 0.14
JNK activation was determined by monitoring phosphorylation of JNK (Thr183 and Tyr185) and c-Jun (Ser63), which is a substrate of JNK.
Positive_regulation (substrate) of Phosphorylation (phosphorylation) of JNK
16) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.80 Pain Relevance 0.12
JNK phosphorylation in liver, muscle and adipose tissue were increased in septic animals and atorvastatin induced a downmodulation in the phosphorylation of this serine kinase (Fig. 4A–C).
Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK in liver associated with obesity
17) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2997789 Disease Relevance 0.76 Pain Relevance 0.07
In addition, administration of arjunolic acid 4 h after acetaminophen intoxication reduced acetaminophen-induced JNK and downstream Bcl-2 and Bcl-xL phosphorylation, thus protecting against mitochondrial permeabilization, loss of mitochondrial membrane potential, and cytochrome c release.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of JNK associated with paracetamol and poisoning
18) Confidence 0.31 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19969075 Disease Relevance 0.57 Pain Relevance 1.01
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Positive_regulation (induction) of Phosphorylation (phosphorylation) of JNK in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
19) Confidence 0.31 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.07 Pain Relevance 0.56
We have demonstrated, in rats with streptozotocin-induced diabetes, that mechanical hyperalgesia, a common symptom of diabetic neuropathy, was correlated with an early increase in extracellular signal-regulated protein kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) phosphorylation in the spinal cord and dorsal root ganglion at 3 weeks after induction of diabetes.
Positive_regulation (increase) of Phosphorylation (phosphorylation) of JNK in spinal cord associated with ganglion cysts, dorsal root ganglion, hyperalgesia, diabetes mellitus, diabetic neuropathy and spinal cord
20) Confidence 0.31 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16868181 Disease Relevance 1.06 Pain Relevance 0.51

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