INT95759

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Context Info
Confidence 0.51
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 13
Disease Relevance 2.55
Pain Relevance 5.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (DIO3) small molecule metabolic process (DIO3) plasma membrane (DIO3)
cellular nitrogen compound metabolic process (DIO3) biological_process (DIO3)
Anatomy Link Frequency
spinal cord 3
striatum 3
gray matter 2
cortex 2
nucleus accumbens 1
DIO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 599 99.62 Very High Very High Very High
Spinal cord 396 99.40 Very High Very High Very High
Nucleus accumbens 6 95.20 Very High Very High Very High
Central nervous system 9 93.28 High High
Substantia nigra 15 91.00 High High
Pain 64 83.12 Quite High
Tetrahydrobiopterin 2 78.56 Quite High
Dorsal horn 45 76.96 Quite High
spinal dorsal horn 18 75.44 Quite High
dopamine receptor 11 75.00 Quite High
Disease Link Frequency Relevance Heat
Adhesions 6 99.26 Very High Very High Very High
Dystonia 10 96.56 Very High Very High Very High
Adrenoleukodystrophy 3 95.32 Very High Very High Very High
Pain 55 83.12 Quite High
Muscle Hypotonia 1 74.88 Quite High
Uveitis 1 74.48 Quite High
Convulsion 1 73.28 Quite High
Parkinson's Disease 324 72.84 Quite High
Disease 66 71.76 Quite High
Ocular Toxicity (including Many Sub-types) 2 71.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Males also expressed higher activities of genes promoting cell adhesion (cell adhesion molecule 1 and claudin 16), elastin deposition in the extracellular matrix (lysyl oxidase-like 1), mucin-type O-linked glycosylation (UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6), thyroid hormone inactivation (Type III iodothyronine deiodinase), lysophospholipid hydrolysis (ectonucleotide pyrophosphatase/ phosphodiesterase 2) and neurite outgrowth and arborization (neuritin 1).
Gene_expression (deposition) of Type III iodothyronine deiodinase in extracellular matrix associated with adhesions
1) Confidence 0.51 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790476 Disease Relevance 0.34 Pain Relevance 0
The disorders of peroxisomal beta-oxidation, which have been well characterised at the molecular level, include defects of acyl-CoA oxidase, defects of the D-bifunctional protein (D-BP) (including specific defects of its enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase components), defects of the very-long-chain fatty acid (VLCFA)-CoA importer [X-linked adrenoleukodystrophy (ALD)] and alpha-methylacyl-CoA racemase deficiency.
Gene_expression (defects) of D-3 associated with adrenoleukodystrophy
2) Confidence 0.29 Published 2001 Journal Biochem. Soc. Trans. Section Abstract Doc Link 11356171 Disease Relevance 0.52 Pain Relevance 0.10
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Gene_expression (expression) of D-3 in nucleus accumbens associated with nucleus accumbens and dopamine
3) Confidence 0.29 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.60
The detection of D3 labeling showed that the cells expressing D3 receptors were more homogeneously distributed within the gray matter, i.e. laminae I to X, as illustrated in Figure 2D.
Gene_expression (expressing) of D3 in gray matter
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.28
By contrast, we show that the D2 and D3 receptor subtypes are expressed in the lumbar spinal cord as in the rat where the D2 [58], [59] and D3 [60] receptor subtypes are highly expressed.
Gene_expression (expressed) of D3 in spinal cord associated with spinal cord
5) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.15 Pain Relevance 0.79
Overall, D2, D3 and D5 receptor subtypes were expressed in the lumbar spinal cord sections.
Gene_expression (expressed) of D3 in spinal cord associated with spinal cord
6) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.11 Pain Relevance 0.49
By contrast, we show that the D2 and D3 receptor subtypes are expressed in the lumbar spinal cord as in the rat where the D2 [58], [59] and D3 [60] receptor subtypes are highly expressed.
Gene_expression (expressed) of D3 in spinal cord associated with spinal cord
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.14 Pain Relevance 0.72
In the present study, the density of striatal DA terminals and DA receptors and the expression of D-1, D-2, and D-3 receptors, preproenkephalin (PPE-A), preprotachykinin (PPT), and nitric oxide synthase (NOS) mRNAs in the striatum and nucleus accumbens and nigral TH mRNA expression were examined.
Gene_expression (expression) of D-3 in striatum associated with nucleus accumbens and dopamine
8) Confidence 0.10 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530890 Disease Relevance 0.36 Pain Relevance 0.60
The detection of D3 labeling showed that the cells expressing D3 receptors were more homogeneously distributed within the gray matter, i.e. laminae I to X, as illustrated in Figure 2D.
Gene_expression (detection) of D3 in gray matter
9) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0 Pain Relevance 0.29
As expected, D1 and D2 receptor subtypes were mainly expressed within the striatum and cortex, D3 mainly expressed within the ventral striatum and the Islands of Calleja and D5 mainly expressed within the cortex (Fig. 1) [38].
Gene_expression (expressed) of D3 in striatum
10) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.14 Pain Relevance 0.35
As expected, D1 and D2 receptor subtypes were mainly expressed within the striatum and cortex, D3 mainly expressed within the ventral striatum and the Islands of Calleja and D5 mainly expressed within the cortex (Fig. 1) [38].
Gene_expression (expressed) of D3 in striatum
11) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.14 Pain Relevance 0.35
As expected, D1 and D2 receptor subtypes were mainly expressed within the striatum and cortex, D3 mainly expressed within the ventral striatum and the Islands of Calleja and D5 mainly expressed within the cortex (Fig. 1) [38].
Gene_expression (expressed) of D3 in cortex
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.14 Pain Relevance 0.35
As expected, D1 and D2 receptor subtypes were mainly expressed within the striatum and cortex, D3 mainly expressed within the ventral striatum and the Islands of Calleja and D5 mainly expressed within the cortex (Fig. 1) [38].
Gene_expression (expressed) of D3 in cortex
13) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2954154 Disease Relevance 0.14 Pain Relevance 0.35

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