INT95760

Context Info Confidence 0.00 First Reported 2001 Last Reported 2001 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.93 Pain Relevance 0.20

cytosol (ACO1) mitochondrion (ACO1) lyase activity (ACO1) Golgi apparatus (ACO1) endoplasmic reticulum (ACO1) RNA binding (ACO1)

ACO1 (Homo sapiens)

Pain Link Frequency Relevance Heat anesthesia 2 68.24 imagery 2 64.40

Disease Link Frequency Relevance Heat Adrenoleukodystrophy 6 95.00 Muscle Hypotonia 2 74.24 Convulsion 2 72.64 Ocular Toxicity (including Many Sub-types) 4 70.48 Disease 2 58.16 Neurological Disease 2 49.76 Cognitive Disorder 2 47.28 Neuropathic Pain 2 40.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The disorders of peroxisomal beta-oxidation, which have been well characterised at the molecular level, include defects of acyl-CoA oxidase, defects of the D-bifunctional protein (D-BP) (including specific defects of its enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase components), defects of the very-long-chain fatty acid (VLCFA)-CoA importer [X-linked adrenoleukodystrophy (ALD)] and alpha-methylacyl-CoA racemase deficiency.

Negative_regulation (defects) of Gene_expression (defects) of hydratase associated with adrenoleukodystrophy

1) Confidence 0.00 Published 2001 Journal Biochem. Soc. Trans. Section Abstract Doc Link 11356171 Disease Relevance 0.46 Pain Relevance 0.10

The disorders of peroxisomal beta-oxidation, which have been well characterised at the molecular level, include defects of acyl-CoA oxidase, defects of the D-bifunctional protein (D-BP) (including specific defects of its enoyl-CoA hydratase and D-3-hydroxyacyl-CoA dehydrogenase components), defects of the very-long-chain fatty acid (VLCFA)-CoA importer [X-linked adrenoleukodystrophy (ALD)] and alpha-methylacyl-CoA racemase deficiency.

Negative_regulation (defects) of Gene_expression (defects) of hydratase associated with adrenoleukodystrophy

2) Confidence 0.00 Published 2001 Journal Biochem. Soc. Trans. Section Abstract Doc Link 11356171 Disease Relevance 0.46 Pain Relevance 0.10

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