INT95767

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Context Info
Confidence 0.57
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 72
Total Number 72
Disease Relevance 49.14
Pain Relevance 17.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp9) extracellular space (Mmp9) extracellular region (Mmp9)
proteinaceous extracellular matrix (Mmp9) extracellular matrix organization (Mmp9) protein complex (Mmp9)
Anatomy Link Frequency
brain 4
macrophage 3
fibroblasts 3
hippocampus 2
hepatocytes 1
Mmp9 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1392 100.00 Very High Very High Very High
Inflammation 778 100.00 Very High Very High Very High
cva 36 99.92 Very High Very High Very High
withdrawal 9 99.82 Very High Very High Very High
dexamethasone 49 99.70 Very High Very High Very High
Morphine 10 99.60 Very High Very High Very High
fibrosis 456 99.32 Very High Very High Very High
Central nervous system 206 98.88 Very High Very High Very High
Hippocampus 7 98.88 Very High Very High Very High
Multiple sclerosis 91 97.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 874 100.00 Very High Very High Very High
Injury 487 100.00 Very High Very High Very High
Cerebral Edema 50 99.96 Very High Very High Very High
Cv General 4 Under Development 41 99.92 Very High Very High Very High
Neutropenia 5 99.90 Very High Very High Very High
Syndrome 206 99.86 Very High Very High Very High
Glioma 528 99.84 Very High Very High Very High
Hydronephrosis 77 99.84 Very High Very High Very High
Middle Cerebral Artery Infarction 9 99.70 Very High Very High Very High
Autoimmune Disease 57 99.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: The discovery that deficiency of this well-characterized gelatinase/collagenase results in an inherited form of an osteolytic and arthritic disorder provides an invaluable insights for the understanding of osteolysis and arthritis and is the first genetic evidence that MMP2 deficiency is important in growth and development.


Negative_regulation (deficiency) of gelatinase
1) Confidence 0.57 Published 2005 Journal Saudi Med J Section Body Doc Link 15756348 Disease Relevance 0 Pain Relevance 0
We therefore performed an assay to investigate the ability of Marimastat to inhibit gelatinase (MMP-2, MMP-9) and interstitial collagenase (MMP-1) activities.
Negative_regulation (inhibit) of gelatinase
2) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.26 Pain Relevance 0.07
Rapid increase in serum levels of matrix metalloproteinase-9 (MMP-9) postoperatively is associated with a decrease in the amount of intracellular MMP-9.
Negative_regulation (decrease) of MMP-9 associated with metalloproteinase
3) Confidence 0.49 Published 2005 Journal Surgical innovation Section Title Doc Link 16424954 Disease Relevance 0.17 Pain Relevance 0.20
Inhibition of MMP-9 in conjunction with these operations might be useful to decrease possible brain damage.
Negative_regulation (Inhibition) of MMP-9 in brain associated with metalloproteinase
4) Confidence 0.48 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 1.16 Pain Relevance 0.56
In animal experiments it has been demonstrated that inhibition of MMP-9 reduces brain injury after stroke 23.
Negative_regulation (inhibition) of MMP-9 in brain associated with stroke, metalloproteinase and brain injury
5) Confidence 0.48 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1868659 Disease Relevance 0.75 Pain Relevance 0.41
Injection of KB-R7785 (100 mg/kg) 30 min before MCAO significantly decreased both MMP-9 activity and infarct volume determined at 24 h.
Negative_regulation (decreased) of MMP-9 associated with middle cerebral artery infarction
6) Confidence 0.46 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11356303 Disease Relevance 0.80 Pain Relevance 0.47
The correlation of these levels with differences in hydroxyproline levels in the lungs of bleomycin-treated mice strongly suggests that a reduced molar pro-MMP-9/TIMP-1 ratio in BAL fluid is associated with collagen deposition, beginning as early as the inflammatory events at day 1 after bleomycin administration.
Negative_regulation (reduced) of pro-MMP-9/TIMP-1 in molar associated with inflammation
7) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.89 Pain Relevance 0.29
MMP-9 activity was also reduced in conditioned media from LP07 cells treated with celecoxib.
Negative_regulation (reduced) of MMP-9
8) Confidence 0.42 Published 2004 Journal Int. J. Cancer Section Abstract Doc Link 15170663 Disease Relevance 1.78 Pain Relevance 0.46
In this study, mice treated with BB-94 as well as mice deficient in Mmp2, Mmp3 or Mmp9 had lower levels of apoptosis and necrosis of hepatocytes, and better survival.
Negative_regulation (deficient) of Mmp9 in hepatocytes associated with necrosis and apoptosis
9) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.83 Pain Relevance 0.09
Marimastat efficiently inhibits MMP-2, MMP-3, MMP-7, MMP-9, MMP-13 and TACE activity, with IC50s in the nM range [26], [54].
Negative_regulation (inhibits) of MMP-9
10) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.10 Pain Relevance 0.03
The serum concentration of TIMP-1, an inhibitor of MMP-9, was also higher in SSc patients than in healthy controls (157.1 ± 13.2 ng/ml versus 77.7 ± 12.5 ng/ml, P < 0.001), but SSc patients had higher MMP-9/TIMP-1 ratios than healthy controls (233.0 ± 27.1 versus 69.5 ± 24.3, P < 0.001).
Negative_regulation (inhibitor) of MMP-9 associated with systemic sclerosis
11) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 0.65 Pain Relevance 0.03
In the present study, we measured the expression of MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9, in the sera and culture supernatants of dermal fibroblasts from SSc patients and compared them with serum concentrations of transforming growth factor ?
Negative_regulation (inhibitor) of MMP-9 in fibroblasts associated with metalloproteinase and systemic sclerosis
12) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.40 Pain Relevance 0.41
In the present study, we measured the expression of MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9, in the sera and culture supernatants of dermal fibroblasts from SSc patients and compared them with serum concentrations of transforming growth factor ?
Negative_regulation (inhibitor) of MMP-9 in fibroblasts associated with metalloproteinase and systemic sclerosis
13) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.36 Pain Relevance 0.40
Morphine withdrawal-induced MMP-9 activity is also reduced by an nNOS inhibitor.
Negative_regulation (reduced) of MMP-9 associated with withdrawal and morphine
14) Confidence 0.37 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20519536 Disease Relevance 0.44 Pain Relevance 1.60
Densitometric analysis of the zones of gelatinolysis revealed a reduced proteolytic activity of MMP-9 in those supernatants derived from PBMCs treated with minocycline (3.0 mg/ml) compared to control (PBS).
Negative_regulation (reduced) of MMP-9 associated with metalloproteinase
15) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613526 Disease Relevance 0.21 Pain Relevance 0.36
We show that after a single dose of CCl4 animals deficient in Mmp9 exhibited similar hepatic injury compared to their wild type controls, as assessed by histology and serum ALT levels after 24 h.
Negative_regulation (deficient) of Mmp9 associated with injury
16) Confidence 0.36 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.94 Pain Relevance 0.08
Melatonin at a dose of 60 mg/kg b.w. downregulated MMP-9 and -3 both at the enzyme and protein levels in mouse gastric tissues during prevention as well as healing of acute gastric ulcers.
Negative_regulation (downregulated) of MMP-9 associated with peptic ulcer
17) Confidence 0.36 Published 2009 Journal J. Pineal Res. Section Abstract Doc Link 19522738 Disease Relevance 0.88 Pain Relevance 0.66
The patients (n = 42) with SSc had higher concentrations of MMP-9 and of tissue inhibitor of metalloproteinase-1 (TIMP-1) and a higher ratio of MMP-9 to TIMP-1 in sera than healthy controls (n = 32).
Negative_regulation (inhibitor) of MMP-9 associated with metalloproteinase and systemic sclerosis
18) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064883 Disease Relevance 0.91 Pain Relevance 0.18
Doxycycline shown as a TTR fibril disrupter in vitro [9], when tested in transgenic TTR V30M mice, was capable of disaggregating amyloid deposits with concomitant decrease of metalloproteinase 9 (MMP-9), tissue inhibitor of metalloproteinase (TIMP-1), serum amyloid P component (SAP) and neutrophil gelatinase-associated lipocalin NGAL [10,11].
Negative_regulation (decrease) of MMP-9 in neutrophil associated with targeted disruption, alzheimer's dementia, metalloproteinase and amyloid plaque
19) Confidence 0.34 Published 2010 Journal J Transl Med Section Body Doc Link PMC2922089 Disease Relevance 1.49 Pain Relevance 0.24
Detection of MMP-9 activities by gel zymography
Negative_regulation (Detection) of MMP-9
20) Confidence 0.34 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 0.07 Pain Relevance 0

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