INT95778

Context Info Confidence 0.75 First Reported 2001 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 2.30 Pain Relevance 2.97

cytosol (Prkcb) histone binding (Prkcb) plasma membrane (Prkcb) nucleus (Prkcb) kinase activity (Prkcb) cytoplasm (Prkcb)

Anatomy Link Frequency spinal cord 2 duct 2 kidney 1 Prkcb (Mus musculus)

Pain Link Frequency Relevance Heat Kinase C 29 100.00 Spinal cord 10 99.44 Calcitonin gene-related peptide 1 97.68 substance P 1 94.80 intrathecal 8 90.08 agonist 8 85.84 antagonist 1 84.24 Pain 1 83.88 anesthesia 5 81.84 Enkephalin 4 75.00

Disease Link Frequency Relevance Heat Acid Base Imbalance 4 97.04 Targeted Disruption 9 94.56 Diabetes Mellitus 12 94.12 Pain 1 83.88 Frailty 1 81.92 Neuropathic Pain 2 75.20 Attention Deficit Hyperactivity Disorder 2 75.00 Nociception 1 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Considering that PKC-beta I and -beta II are coexpressed with PKC-alpha in mouse medullary collecting duct, the present results indicate that conventional PKC isoenzymes cannot fully compensate for each other.

Gene_expression (coexpressed) of PKC-beta in duct associated with kinase c

1) Confidence 0.75 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15039142 Disease Relevance 0.05 Pain Relevance 0.62

In conclusion, first evidence is presented that (i) PKC-beta contributes to the regulation of arterial blood pressure, and (ii) PKC-beta is required for normal acid-base balance, which may relate to its expression and function in intercalated cells of the collecting duct.

Gene_expression (contributes) of PKC-beta in duct

2) Confidence 0.67 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16582576 Disease Relevance 0.24 Pain Relevance 0.15

The conventional protein kinase C isoenzyme beta (PKC-beta) is expressed in various structures of mouse kidney.

Gene_expression (expressed) of PKC-beta in kidney associated with kinase c

3) Confidence 0.52 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16582576 Disease Relevance 0.17 Pain Relevance 0.15

Membrane PKC-betaII isoform expression was contrariwise increased.

Gene_expression (expression) of PKC-betaII isoform associated with kinase c

4) Confidence 0.08 Published 2004 Journal Diabetes Section Abstract Doc Link 15561956 Disease Relevance 1.85 Pain Relevance 0.41

Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.

Gene_expression (levels) of PKCbetaII in spinal cord associated with spinal cord

5) Confidence 0.07 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.83

Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.

Gene_expression (levels) of PKCbetaI in spinal cord associated with spinal cord

6) Confidence 0.07 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.82

General Comments

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