INT95778

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.30
Pain Relevance 2.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcb) histone binding (Prkcb) plasma membrane (Prkcb)
nucleus (Prkcb) kinase activity (Prkcb) cytoplasm (Prkcb)
Anatomy Link Frequency
spinal cord 2
duct 2
kidney 1
Prkcb (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 29 100.00 Very High Very High Very High
Spinal cord 10 99.44 Very High Very High Very High
Calcitonin gene-related peptide 1 97.68 Very High Very High Very High
substance P 1 94.80 High High
intrathecal 8 90.08 High High
agonist 8 85.84 High High
antagonist 1 84.24 Quite High
Pain 1 83.88 Quite High
anesthesia 5 81.84 Quite High
Enkephalin 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Acid Base Imbalance 4 97.04 Very High Very High Very High
Targeted Disruption 9 94.56 High High
Diabetes Mellitus 12 94.12 High High
Pain 1 83.88 Quite High
Frailty 1 81.92 Quite High
Neuropathic Pain 2 75.20 Quite High
Attention Deficit Hyperactivity Disorder 2 75.00 Quite High
Nociception 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Considering that PKC-beta I and -beta II are coexpressed with PKC-alpha in mouse medullary collecting duct, the present results indicate that conventional PKC isoenzymes cannot fully compensate for each other.
Gene_expression (coexpressed) of PKC-beta in duct associated with kinase c
1) Confidence 0.75 Published 2004 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15039142 Disease Relevance 0.05 Pain Relevance 0.62
In conclusion, first evidence is presented that (i) PKC-beta contributes to the regulation of arterial blood pressure, and (ii) PKC-beta is required for normal acid-base balance, which may relate to its expression and function in intercalated cells of the collecting duct.
Gene_expression (contributes) of PKC-beta in duct
2) Confidence 0.67 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16582576 Disease Relevance 0.24 Pain Relevance 0.15
The conventional protein kinase C isoenzyme beta (PKC-beta) is expressed in various structures of mouse kidney.
Gene_expression (expressed) of PKC-beta in kidney associated with kinase c
3) Confidence 0.52 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16582576 Disease Relevance 0.17 Pain Relevance 0.15
Membrane PKC-betaII isoform expression was contrariwise increased.
Gene_expression (expression) of PKC-betaII isoform associated with kinase c
4) Confidence 0.08 Published 2004 Journal Diabetes Section Abstract Doc Link 15561956 Disease Relevance 1.85 Pain Relevance 0.41
Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.
Gene_expression (levels) of PKCbetaII in spinal cord associated with spinal cord
5) Confidence 0.07 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.83
Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.
Gene_expression (levels) of PKCbetaI in spinal cord associated with spinal cord
6) Confidence 0.07 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.82

General Comments

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