INT9578

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Context Info
Confidence 0.09
First Reported 1989
Last Reported 2010
Negated 2
Speculated 2
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.21
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Adarb1) mRNA processing (Adarb1) nucleolus (Adarb1)
RNA binding (Adarb1) nucleus (Adarb1) intracellular (Adarb1)
Anatomy Link Frequency
neurons 2
cerebral cortex 2
Adarb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Versed 4 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
Substantia gelatinosa neuron 2 100.00 Very High Very High Very High
noradrenaline 2 100.00 Very High Very High Very High
gABA 1 100.00 Very High Very High Very High
agonist 12 99.78 Very High Very High Very High
fortral 4 99.74 Very High Very High Very High
opiate 15 99.62 Very High Very High Very High
Immobilon 3 99.16 Very High Very High Very High
opioid receptor 1 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 3 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chronic opiate agonist treatment (24 h) of the cultured cells with either 10 microM U50488 (a selective kappa agonist), or 1 microM etorphine (a nonselective opiate agonist), did not change the number of kappa receptors and their binding affinity to [3H]diprenorphine.
Neg (not) Regulation (change) of receptors Binding (affinity) of associated with agonist, opiate and immobilon
1) Confidence 0.09 Published 1990 Journal Brain Res. Section Abstract Doc Link 2165432 Disease Relevance 0.21 Pain Relevance 1.31
There was no apparent alteration in binding to delta receptors.
Neg (no) Regulation (alteration) of receptors Binding (binding) of
2) Confidence 0.05 Published 1989 Journal Neuroscience Section Abstract Doc Link 2542839 Disease Relevance 0 Pain Relevance 0.62
Thus, the effects of midazolam on extrasynaptic gamma-aminobutyric acid (GABA) type A receptors in substantia gelatinosa neurons and interaction with noradrenaline, a transmitter of the descending inhibitory systems, were investigated.
Spec (investigated) Regulation (effects) of receptors Binding (interaction) of in neurons associated with gaba, versed, noradrenaline and substantia gelatinosa neuron
3) Confidence 0.04 Published 2010 Journal Anesthesiology Section Abstract Doc Link 20613474 Disease Relevance 0 Pain Relevance 0.67
We examined the effects of NTB on the specific binding of radiolabeled ligands for opioid mu and kappa2 receptors, and the effects on the release of [3H]norepinephrine ([3H]NE) in rat cerebral cortex slices.
Spec (examined) Regulation (effects) of receptors Spec (examined) Binding (ligands) of in cerebral cortex associated with cerebral cortex and opioid
4) Confidence 0.03 Published 2001 Journal Life Sci. Section Abstract Doc Link 11233997 Disease Relevance 0 Pain Relevance 0.39
Differential effects of cytochrome P-450 induction on ligand binding to sigma receptors.
Regulation (effects) of receptors Binding (binding) of associated with fortral
5) Confidence 0.02 Published 1992 Journal Eur. J. Pharmacol. Section Title Doc Link 1426026 Disease Relevance 0 Pain Relevance 0.38

General Comments

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