INT95780

Context Info Confidence 0.50 First Reported 2001 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 4 Disease Relevance 0.48 Pain Relevance 2.06

cytosol (Prkcb) histone binding (Prkcb) plasma membrane (Prkcb) nucleus (Prkcb) kinase activity (Prkcb) cytoplasm (Prkcb)

Anatomy Link Frequency spinal cord 2 blood 1 duct 1 Prkcb (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 10 99.44 Kinase C 10 91.96 intrathecal 8 90.64 agonist 8 86.40 anesthesia 4 86.20 Enkephalin 4 75.00 Opioid 4 75.00 opioid receptor 2 52.68

Disease Link Frequency Relevance Heat Acid Base Imbalance 4 100.00 Targeted Disruption 2 69.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In conclusion, first evidence is presented that (i) PKC-beta contributes to the regulation of arterial blood pressure, and (ii) PKC-beta is required for normal acid-base balance, which may relate to its expression and function in intercalated cells of the collecting duct.

Positive_regulation (required) of PKC-beta in duct

1) Confidence 0.50 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16582576 Disease Relevance 0.23 Pain Relevance 0.14

Chronic acid loading (NH4Cl) did not affect blood pH in PKC-beta+/+ mice, but induced a modest metabolic acidosis in PKC-beta-/- mice.

Positive_regulation (induced) of PKC-beta in blood associated with acid base imbalance

2) Confidence 0.50 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16582576 Disease Relevance 0.24 Pain Relevance 0.16

Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.

Positive_regulation (increased) of PKCbetaI in spinal cord associated with spinal cord

3) Confidence 0.04 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.88

Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.

Positive_regulation (increased) of PKCbetaII in spinal cord associated with spinal cord

4) Confidence 0.04 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.88

General Comments

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