INT95780

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.50
First Reported 2001
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.48
Pain Relevance 2.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcb) histone binding (Prkcb) plasma membrane (Prkcb)
nucleus (Prkcb) kinase activity (Prkcb) cytoplasm (Prkcb)
Anatomy Link Frequency
spinal cord 2
blood 1
duct 1
Prkcb (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 10 99.44 Very High Very High Very High
Kinase C 10 91.96 High High
intrathecal 8 90.64 High High
agonist 8 86.40 High High
anesthesia 4 86.20 High High
Enkephalin 4 75.00 Quite High
Opioid 4 75.00 Quite High
opioid receptor 2 52.68 Quite High
Disease Link Frequency Relevance Heat
Acid Base Imbalance 4 100.00 Very High Very High Very High
Targeted Disruption 2 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, first evidence is presented that (i) PKC-beta contributes to the regulation of arterial blood pressure, and (ii) PKC-beta is required for normal acid-base balance, which may relate to its expression and function in intercalated cells of the collecting duct.
Positive_regulation (required) of PKC-beta in duct
1) Confidence 0.50 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16582576 Disease Relevance 0.23 Pain Relevance 0.14
Chronic acid loading (NH4Cl) did not affect blood pH in PKC-beta+/+ mice, but induced a modest metabolic acidosis in PKC-beta-/- mice.
Positive_regulation (induced) of PKC-beta in blood associated with acid base imbalance
2) Confidence 0.50 Published 2006 Journal Kidney Blood Press. Res. Section Abstract Doc Link 16582576 Disease Relevance 0.24 Pain Relevance 0.16
Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.
Positive_regulation (increased) of PKCbetaI in spinal cord associated with spinal cord
3) Confidence 0.04 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.88
Western blotting analysis showed that chronic DAMGO treatment increased the levels of PKCgamma, but not PKCalpha, PKCbetaI, and PKCbetaII isoforms, in spinal cord membranes.
Positive_regulation (increased) of PKCbetaII in spinal cord associated with spinal cord
4) Confidence 0.04 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356858 Disease Relevance 0 Pain Relevance 0.88

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox