INT95784

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Context Info
Confidence 0.11
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 9
Disease Relevance 3.48
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
spinal cord 2
internal 2
synapses 2
dorsal horn 2
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 6 99.68 Very High Very High Very High
depression 78 99.40 Very High Very High Very High
Dorsal horn neuron 12 99.40 Very High Very High Very High
Hippocampus 22 98.84 Very High Very High Very High
Spinal cord 9 98.44 Very High Very High Very High
Neuronal excitability 10 98.24 Very High Very High Very High
Kinase C 1 97.64 Very High Very High Very High
potassium channel 2 97.28 Very High Very High Very High
antagonist 27 95.28 Very High Very High Very High
Calcium channel 28 94.72 High High
Disease Link Frequency Relevance Heat
Depression 78 99.40 Very High Very High Very High
Nociception 16 96.12 Very High Very High Very High
Targeted Disruption 20 94.68 High High
INFLAMMATION 2 93.76 High High
Injury 2 87.84 High High
Hypersensitivity 2 87.04 High High
Neurodegenerative Disease 1 86.08 High High
Disease 11 82.08 Quite High
Anxiety Disorder 30 81.36 Quite High
Schizophrenia 16 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord.
Positive_regulation (leads) of Positive_regulation (activation) of mGluR5 in spinal cord associated with spinal cord
1) Confidence 0.11 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.60 Pain Relevance 0.71
This medium-duration ADP is rapidly and reversibly induced by activation of mGluR5 and requires activation of phospholipase C (PLC) and release of calcium from internal stores.
Positive_regulation (induced) of Positive_regulation (activation) of mGluR5 in internal
2) Confidence 0.07 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.40
Stimulation of mGluR5 leads to the release of calcium from intracellular supplies and protein kinase C activation.
Positive_regulation (leads) of Positive_regulation (Stimulation) of mGluR5 associated with kinase c
3) Confidence 0.07 Published 2007 Journal Curr Top Med Chem Section Abstract Doc Link 17979788 Disease Relevance 0.77 Pain Relevance 0.59
Thus, as previously described at the PrPFC to nucleus accumbens synapses [28], activation of mGluR5 is necessary to induce eCB-LTD via a yet unidentified eCB that activates presynaptic CB1R.
Positive_regulation (necessary) of Positive_regulation (activation) of mGluR5 in synapses associated with nucleus accumbens and depression
4) Confidence 0.06 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.86 Pain Relevance 0.72
Accomplishing this task will require that the balance of two competing factors be determined: the enhanced activation of mGluRs during periods of high activity and the activity-dependent inhibition of the ADP during high-frequency spiking.
Positive_regulation (enhanced) of Positive_regulation (activation) of mGluRs
5) Confidence 0.06 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.11
Activation of mGluR5 is necessary for L-LTP, via the phosphorylation of p70 S6 kinase, which is a major regulator of translation required for the protein synthesis-dependent L-LTP [41].
Positive_regulation (necessary) of Positive_regulation (Activation) of mGluR5
6) Confidence 0.04 Published 2009 Journal Mol Brain Section Body Doc Link PMC2663561 Disease Relevance 0.07 Pain Relevance 0.08
The reasons for the efficiency of this frequency range are not clear but it is possible that this frequency allows for the full activation of perisynaptic mGluR5 [46].
Positive_regulation (allows) of Positive_regulation (activation) of mGluR5
7) Confidence 0.04 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 0.18 Pain Relevance 0.16
These effects were mediated by activation of mGlu5, but not mGlu1, and were dependent on ERK activation.
Positive_regulation (mediated) of Positive_regulation (activation) of mGlu5
8) Confidence 0.01 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18045912 Disease Relevance 0.54 Pain Relevance 0.60
Altogether, our results indicate that activation of mGlu5 leads to ERK-mediated phosphorylation and modulation of Kv4.2-containing potassium channels in dorsal horn neurons.
Positive_regulation (leads) of Positive_regulation (activation) of mGlu5 in dorsal horn associated with potassium channel and dorsal horn neuron
9) Confidence 0.01 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18045912 Disease Relevance 0.45 Pain Relevance 0.64

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