INT95785

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.59
Pain Relevance 3.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm1) plasma membrane (Grm1) nucleus (Grm1)
signal transducer activity (Grm1)
Anatomy Link Frequency
pyramidal neurons 2
spinal cord 2
VPL 2
Grm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 5 99.98 Very High Very High Very High
depression 57 99.96 Very High Very High Very High
Pain 9 99.96 Very High Very High Very High
Dorsal horn neuron 8 99.40 Very High Very High Very High
Spinal cord 8 98.44 Very High Very High Very High
Neuronal excitability 5 98.24 Very High Very High Very High
Pyramidal cell 15 95.16 Very High Very High Very High
Intracerebroventricular 1 94.92 High High
Inflammation 6 93.76 High High
antagonist 9 93.16 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 99.98 Very High Very High Very High
Depression 57 99.96 Very High Very High Very High
Pain 7 99.96 Very High Very High Very High
Nociception 14 96.12 Very High Very High Very High
INFLAMMATION 3 93.76 High High
Targeted Disruption 15 93.60 High High
Inflammatory Pain 5 90.20 High High
Injury 1 87.84 High High
Hypersensitivity 1 87.04 High High
Congenital Anomalies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord.
Positive_regulation (leads) of Positive_regulation (activation) of mGluR1 in spinal cord associated with spinal cord
1) Confidence 0.49 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.60 Pain Relevance 0.71
We also show for the first time that i.t. injection of pSM2 (pShag Magic version 2)-grin2b (coding for an short-hairpin RNA to the NR2B subunit of the NMDAR) resulted in a dose-dependent decrease in the NR2B protein and blockade of hyperalgesia induced by activation of the mGluR1/5 in (S)-3,5-DHPG-treated mice.
Positive_regulation (induced) of Positive_regulation (activation) of mGluR1 associated with hyperalgesia
2) Confidence 0.49 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17405869 Disease Relevance 0.34 Pain Relevance 0.66
Furthermore, activation of mGluR1 at the VPL enhanced pain behavior in the second phase in the wild-type mice.
Positive_regulation (enhanced) of Positive_regulation (activation) of mGluR1 in VPL associated with pain
3) Confidence 0.06 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12954872 Disease Relevance 1.32 Pain Relevance 0.89
Ca2+ influx through voltage-gated Ca2+ channels, mGluR1 activation and AMPA receptor activation are required to induce LTD [36], [37].
Positive_regulation (induce) of Positive_regulation (activation) of mGluR1 associated with depression
4) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386150 Disease Relevance 0.79 Pain Relevance 0.39
Our finding that both mGluR5 and mGluR1 activation are required for the full effect of DHPG is consistent with previous work demonstrating the effects of both receptor subtypes in CA1 pyramidal neurons [26],[41],[44], despite greater expression of the mGluR5 subunit [50]–[55].
Positive_regulation (required) of Positive_regulation (activation) of mGluR1 in pyramidal neurons associated with pyramidal cell
5) Confidence 0.02 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.05
These effects were mediated by activation of mGlu5, but not mGlu1, and were dependent on ERK activation.
Positive_regulation (mediated) of Positive_regulation (activation) of mGlu1
6) Confidence 0.00 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 18045912 Disease Relevance 0.55 Pain Relevance 0.60

General Comments

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