INT95786

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Context Info
Confidence 0.40
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.27
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) protein complex assembly (Mapk3) protein complex (Mapk3)
cytoplasm (Mapk3) cytosol (Mapk3) signal transduction (Mapk3)
Anatomy Link Frequency
spinal cord 2
mesangial cells 2
Mapk3 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 3 99.32 Very High Very High Very High
fibrosis 2 99.24 Very High Very High Very High
Dorsal horn neuron 4 98.12 Very High Very High Very High
Inflammation 6 95.52 Very High Very High Very High
nociceptor 1 88.44 High High
Glutamate receptor 3 75.92 Quite High
IPN 1 75.00 Quite High
Pain 1 60.88 Quite High
chemokine 1 35.24 Quite Low
Bioavailability 1 29.44 Quite Low
Disease Link Frequency Relevance Heat
Fibrosis 3 99.24 Very High Very High Very High
INFLAMMATION 4 95.52 Very High Very High Very High
Nociception 5 94.84 High High
Diabetes Mellitus 28 93.88 High High
Disease 8 93.20 High High
Renal Disease 23 76.72 Quite High
Inflammatory Pain 1 75.00 Quite High
Vasculitis 1 67.56 Quite High
Stress 1 66.52 Quite High
Chronic Renal Failure 64 54.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord.
Positive_regulation (leads) of Positive_regulation (activation) of ERK1 in spinal cord associated with spinal cord
1) Confidence 0.40 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.60 Pain Relevance 0.71
Activation of the (pro)renin receptor in mesangial cells also activates mitogen-activated protein kinase, ERK 1 and 2 and several fibrosis/remodeling mediators such as TGF?
Positive_regulation (activates) of Positive_regulation (mitogen-activated protein kinase) of ERK 1 in mesangial cells associated with fibrosis
2) Confidence 0.05 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.67 Pain Relevance 0.08

General Comments

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