INT95786

Context Info Confidence 0.40 First Reported 2001 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.27 Pain Relevance 0.80

nucleoplasm (Mapk3) protein complex assembly (Mapk3) protein complex (Mapk3) cytoplasm (Mapk3) cytosol (Mapk3) signal transduction (Mapk3)

Anatomy Link Frequency spinal cord 2 mesangial cells 2 Mapk3 (Mus musculus)

Pain Link Frequency Relevance Heat Spinal cord 3 99.32 fibrosis 2 99.24 Dorsal horn neuron 4 98.12 Inflammation 6 95.52 nociceptor 1 88.44 Glutamate receptor 3 75.92 IPN 1 75.00 Pain 1 60.88 chemokine 1 35.24 Bioavailability 1 29.44

Disease Link Frequency Relevance Heat Fibrosis 3 99.24 INFLAMMATION 4 95.52 Nociception 5 94.84 Diabetes Mellitus 28 93.88 Disease 8 93.20 Renal Disease 23 76.72 Inflammatory Pain 1 75.00 Vasculitis 1 67.56 Stress 1 66.52 Chronic Renal Failure 64 54.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord.

Positive_regulation (leads) of Positive_regulation (activation) of ERK1 in spinal cord associated with spinal cord

1) Confidence 0.40 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.60 Pain Relevance 0.71

Activation of the (pro)renin receptor in mesangial cells also activates mitogen-activated protein kinase, ERK 1 and 2 and several fibrosis/remodeling mediators such as TGF?

Positive_regulation (activates) of Positive_regulation (mitogen-activated protein kinase) of ERK 1 in mesangial cells associated with fibrosis

2) Confidence 0.05 Published 2010 Journal Cardiovasc Drugs Ther Section Body Doc Link PMC2887501 Disease Relevance 0.67 Pain Relevance 0.08

General Comments

This test has worked.