INT95788

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2001
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 83
Total Number 84
Disease Relevance 24.75
Pain Relevance 25.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
cortex 8
neuronal 8
CeA 7
frontal cortex 4
spinal cord 4
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 305 100.00 Very High Very High Very High
substance P 29 100.00 Very High Very High Very High
Cannabinoid 15 100.00 Very High Very High Very High
adenocard 12 100.00 Very High Very High Very High
Inflammation 501 99.98 Very High Very High Very High
Nucleus accumbens 164 99.96 Very High Very High Very High
c fibre 62 99.92 Very High Very High Very High
Morphine 33 99.84 Very High Very High Very High
fluoxetine 9 99.84 Very High Very High Very High
agonist 49 99.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 120 100.00 Very High Very High Very High
INFLAMMATION 525 99.98 Very High Very High Very High
Nociception 139 99.80 Very High Very High Very High
Apoptosis 128 99.76 Very High Very High Very High
Injury 43 99.72 Very High Very High Very High
Targeted Disruption 115 99.70 Very High Very High Very High
Inflammatory Pain 50 99.70 Very High Very High Very High
Cancer 733 99.58 Very High Very High Very High
Retinal Neovascularization 4 99.12 Very High Very High Very High
Diabetes Mellitus 341 99.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord.
Positive_regulation (leads) of Positive_regulation (activation) of ERK2 in spinal cord associated with spinal cord
1) Confidence 0.69 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.60 Pain Relevance 0.71
The results demonstrated that the DNAzyme could attenuate the expression of mPer1 in CNS in mice and downregulate the increased extracellular signal-regulated kinase (ERK) activity induced by morphine in whole brain and the nucleus accumbens, the key region of drug addiction.
Positive_regulation (induced) of Positive_regulation (increased) of extracellular signal-regulated kinase in nucleus accumbens associated with drug dependence, addiction, nucleus accumbens and morphine
2) Confidence 0.65 Published 2007 Journal Neuroscience Section Abstract Doc Link 17320300 Disease Relevance 0.17 Pain Relevance 0.71
The results demonstrated that the DNAzyme could attenuate the expression of mPer1 in CNS in mice and downregulate the increased extracellular signal-regulated kinase (ERK) activity induced by morphine in whole brain and the nucleus accumbens, the key region of drug addiction.
Positive_regulation (increased) of Positive_regulation (induced) of ERK in nucleus accumbens associated with drug dependence, addiction, nucleus accumbens and morphine
3) Confidence 0.65 Published 2007 Journal Neuroscience Section Abstract Doc Link 17320300 Disease Relevance 0.17 Pain Relevance 0.71
We observed that primary afferent stimulation recruiting C-fibers was required for both SP and BDNF release and ERK activation in post-synaptic dorsal horn neurons.
Positive_regulation (required) of Positive_regulation (activation) of ERK in neurons associated with c fibre, dorsal horn neuron and substance p
4) Confidence 0.62 Published 2003 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 14572451 Disease Relevance 0 Pain Relevance 0.92
Furthermore, we find that inflammation-evoked ERK activation, which is required for nociceptive plasticity, is downstream of mGluR1 and mGluR5.
Positive_regulation (required) of Positive_regulation (activation) of ERK associated with nociception and inflammation
5) Confidence 0.50 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.60 Pain Relevance 0.72
In the NAcc, activation of the ERK pathway is the main factor responsible for the induction of Fos family genes (including c-fos, fosB and fra2), Zif268 and Egr3 in response to cocaine, D-amph and 3,4-methylenedioxymethamphetamine (MDMA) [15,19,20,24].
Positive_regulation (induction) of Positive_regulation (activation) of ERK associated with nucleus accumbens and cocaine
6) Confidence 0.49 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.52
The involvement of ERK pathway in cannabinoid chronic exposure was also confirmed in Ras-GRF1 knock out mice, a useful model where cannabinoid-induced ERK activation is lost.
Positive_regulation (cannabinoid-induced) of Positive_regulation (activation) of ERK associated with targeted disruption and cannabinoid
7) Confidence 0.49 Published 2004 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15033164 Disease Relevance 0.10 Pain Relevance 0.33
Moreover, chronic THC exposure induced increases in the ERK cascade (ERK, pCREB, and Fos B) in the prefrontal cortex and hippocampus, suggesting that different neuronal circuits seem to be involved in the early phase and late phase of exposure.
Positive_regulation (induced) of Positive_regulation (increases) of ERK in cortex associated with hippocampus
8) Confidence 0.49 Published 2004 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15033164 Disease Relevance 0.08 Pain Relevance 0.26
Moreover, chronic THC exposure induced increases in the ERK cascade (ERK, pCREB, and Fos B) in the prefrontal cortex and hippocampus, suggesting that different neuronal circuits seem to be involved in the early phase and late phase of exposure.
Positive_regulation (induced) of Positive_regulation (increases) of ERK in cortex associated with hippocampus
9) Confidence 0.49 Published 2004 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 15033164 Disease Relevance 0.08 Pain Relevance 0.26
The infused volume and doses of U0126 and U0124 were selected based on our previous biochemical experiments that showed that inhibition of ERK activation by U0126 under these conditions is restricted to the CeA and that 1.5 nmoles of U0126 is the lowest dose that significantly inhibits formalin-induced ERK activation in the CeA [4].


Positive_regulation (induced) of Positive_regulation (activation) of ERK associated with amygdala
10) Confidence 0.48 Published 2008 Journal Mol Pain Section Body Doc Link PMC2443116 Disease Relevance 0.15 Pain Relevance 0.16
Reduced ERK activation after formalin in DN MEK mice
Positive_regulation (after) of Positive_regulation (activation) of ERK
11) Confidence 0.48 Published 2006 Journal Mol Pain Section Body Doc Link PMC1382249 Disease Relevance 0.93 Pain Relevance 0.79
Pretreatment with DRz164 significant attenuated the morphine-induced activation of ERK and CREB in the frontal cortex, hippocampus, and striatum.
Positive_regulation (induced) of Positive_regulation (activation) of ERK in frontal cortex
12) Confidence 0.47 Published 2008 Journal Am J Drug Alcohol Abuse Section Body Doc Link 18850497 Disease Relevance 0 Pain Relevance 0
Activity-dependent ERK activation in vivo
Positive_regulation (dependent) of Positive_regulation (activation) of ERK
13) Confidence 0.47 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.09 Pain Relevance 0.60
Using the formalin test as a mouse model of persistent inflammatory pain, we show that activation of ERK in the amygdala is both necessary for and sufficient to induce long-lasting peripheral hypersensitivity to tactile stimulation.
Positive_regulation (necessary) of Positive_regulation (activation) of ERK in amygdala associated with ipn, hypersensitivity and amygdala
14) Confidence 0.47 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17301163 Disease Relevance 1.19 Pain Relevance 0.90
Addictive and non-addictive drugs induce distinct and specific patterns of ERK activation in mouse brain.
Positive_regulation (induce) of Positive_regulation (activation) of ERK in brain
15) Confidence 0.47 Published 2004 Journal Eur. J. Neurosci. Section Title Doc Link 15078556 Disease Relevance 0 Pain Relevance 0.52
The strong activation of ERK induced by drugs of abuse raises the question of its functional role.
Positive_regulation (activation) of Positive_regulation (induced) of ERK
16) Confidence 0.46 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.20
The strong activation of ERK induced by drugs of abuse raises the question of its functional role.
Positive_regulation (induced) of Positive_regulation (activation) of ERK
17) Confidence 0.46 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.20
Drugs of abuse induce a rapid and strong activation of ERK in a precise and limited set of brain areas including NAcc, bed nucleus of stria terminalis, central amygdala, prefrontal cortex [15,18].
Positive_regulation (induce) of Positive_regulation (activation) of ERK in prefrontal associated with nucleus accumbens and amygdala
18) Confidence 0.46 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.31
These results strongly support the involvement of the ERK pathway in the delayed consequences of repeated psychostimulants administration, confirming and extending our previous finding that ERK activation was necessary for the induction of behavioral sensitization induced by a single injection of cocaine or D-amph [16].


Positive_regulation (necessary) of Positive_regulation (activation) of ERK associated with cocaine
19) Confidence 0.46 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.23
Potential of endogenously expressed insulin receptors (IR) and PDGFR to act as surrogate protein scaffolds during ERK activation by ?
Positive_regulation (during) of Positive_regulation (activation) of ERK
20) Confidence 0.45 Published 2002 Journal BMC Pharmacol Section Body Doc Link PMC88976 Disease Relevance 0.24 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox