INT95789

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Context Info
Confidence 0.55
First Reported 2001
Last Reported 2011
Negated 1
Speculated 0
Reported most in Abstract
Documents 42
Total Number 66
Disease Relevance 20.10
Pain Relevance 33.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
spinal cord 5
neurons 5
pyramidal neurons 4
forebrain 4
nerve 3
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate receptor 241 100.00 Very High Very High Very High
Spinal cord 53 100.00 Very High Very High Very High
Pyramidal cell 430 99.96 Very High Very High Very High
Glutamate 257 99.96 Very High Very High Very High
antagonist 186 99.96 Very High Very High Very High
Calcium channel 350 99.84 Very High Very High Very High
Neuronal excitability 87 99.84 Very High Very High Very High
Morphine 61 99.84 Very High Very High Very High
Dorsal horn neuron 32 99.84 Very High Very High Very High
Spinal nerve ligature 20 99.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 53 100.00 Very High Very High Very High
Schizophrenia 52 99.96 Very High Very High Very High
INFLAMMATION 12 99.76 Very High Very High Very High
Hyperalgesia 36 99.50 Very High Very High Very High
Disease 87 99.44 Very High Very High Very High
Stress 4 99.40 Very High Very High Very High
Depression 160 98.98 Very High Very High Very High
Nervous System Injury 15 98.56 Very High Very High Very High
Targeted Disruption 188 98.46 Very High Very High Very High
Pain 26 98.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings support the idea that the increased mGluR5 following repeated treatment with morphine leads to enhanced neuronal excitability and synaptic transmission in the dorsal horn of the spinal cord and, in turn, suppresses the morphine-induced antinociception in mice.
Positive_regulation (increased) of mGluR5 in neuronal associated with antinociception, neuronal excitability, dorsal horn, spinal cord and morphine
1) Confidence 0.55 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000152 Disease Relevance 0 Pain Relevance 1.65
Double-labeling experiments showed that the increased mGluR5 was predominantly expressed in the neurons and sparsely expressed in the processes of astrocytes following repeated treatment with morphine.
Positive_regulation (increased) of mGluR5 in astrocytes associated with morphine
2) Confidence 0.55 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000152 Disease Relevance 0 Pain Relevance 1.63
Furthermore, repeated treatment with morphine produced a significant increase in the level of mGluR5 immunoreactivity in the dorsal horn of the mouse spinal cord.
Positive_regulation (increase) of mGluR5 in spinal cord associated with dorsal horn, spinal cord and morphine
3) Confidence 0.55 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000152 Disease Relevance 0 Pain Relevance 1.48
Using the receptor binding assay, we found here that the number of mGluR5 in the mouse spinal cord was significantly increased by repeated treatment with morphine.
Positive_regulation (increased) of mGluR5 in spinal cord associated with morphine and spinal cord
4) Confidence 0.48 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16000152 Disease Relevance 0 Pain Relevance 1.40
In addition to AMPA/kainate, NMDA and mGluR5 receptor activation and oxidative stress, BMAA may also induce toxicity by inhibiting the reuptake of glutamate.
Positive_regulation (activation) of mGluR5 associated with stress, toxicity and glutamate
5) Confidence 0.45 Published 2011 Journal International Journal of Microbiology Section Body Doc Link PMC2957129 Disease Relevance 0.28 Pain Relevance 0.37
Moreover, we demonstrate that phosphorylation of extracellular-signal regulated kinase 1/2 (ERK1/2) is downstream of mGluR5 activation in the CeA and is necessary for the full expression of peripheral inflammation-induced behavioral sensitization.
Positive_regulation (activation) of mGluR5 in CeA associated with inflammation and amygdala
6) Confidence 0.23 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554871 Disease Relevance 0.99 Pain Relevance 0.76
We demonstrate that unilateral pharmacological activation of mGluR5 in the CeA produces distinct behavioral responses depending on whether the right or left amygdala is injected.
Positive_regulation (activation) of mGluR5 in amygdala associated with amygdala
7) Confidence 0.23 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20554871 Disease Relevance 0.96 Pain Relevance 0.84
QSAR models capable of combining the structural diversity of different chemical scaffolds into a single model could inform the discovery of new chemotypes for allosteric potentiation of the mGluR5 glutamate response.
Positive_regulation (potentiation) of mGluR5 associated with glutamate
8) Confidence 0.20 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0.07 Pain Relevance 0.34
Machine learning techniques were applied to generate specific QSAR models for allosteric potentiation of the mGluR5 glutamate response.
Positive_regulation (potentiation) of mGluR5 associated with glutamate
9) Confidence 0.20 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0.27
Activation of mGluR5 potentiates NMDAR function in forebrain circuits thought to be disrupted in schizophrenia.
Positive_regulation (Activation) of mGluR5 in forebrain associated with schizophrenia
10) Confidence 0.18 Published 2010 Journal ACS Chemical Neuroscience Section Body Doc Link PMC2857954 Disease Relevance 1.08 Pain Relevance 0.31
These results represent an enrichment factor of 23 for pure potentiation of the mGluR5 glutamate response and 30 for overall mGluR5 modulation activity when compared with those of the original mGluR5 experimental screening data (0.94% hit rate).
Positive_regulation (potentiation) of mGluR5 associated with glutamate
11) Confidence 0.17 Published 2010 Journal ACS Chemical Neuroscience Section Abstract Doc Link PMC2857954 Disease Relevance 0 Pain Relevance 0.24
The effect of group I metabotropic glutamate receptor (mGluR1 and mGluR5) activation on identified melanin-concentrating hormone (MCH) neurons was studied using patch-clamp recording in hypothalamic slices from green fluorescent protein-expressing transgenic mice.
Positive_regulation (activation) of mGluR5 in neurons associated with targeted disruption and glutamate receptor
12) Confidence 0.17 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17959799 Disease Relevance 0.09 Pain Relevance 0.20
These results show that mGluR1 and mGluR5 are activated in dorsal horn neurons in response to peripheral inflammation and that activation of these group I mGluRs leads to activation of ERK1 and ERK2, resulting in enhanced pain sensitivity.
Positive_regulation (activated) of mGluR5 in neurons associated with pain, inflammation and dorsal horn neuron
13) Confidence 0.11 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.73 Pain Relevance 0.72
We show that activation of mGluR1 and mGluR5 leads to activation of ERK1 and ERK2 in the spinal cord.
Positive_regulation (activation) of mGluR5 in spinal cord associated with spinal cord
14) Confidence 0.11 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.60 Pain Relevance 0.71
This medium-duration ADP is rapidly and reversibly induced by activation of mGluR5 and requires activation of phospholipase C (PLC) and release of calcium from internal stores.
Positive_regulation (activation) of mGluR5 in internal
15) Confidence 0.10 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.40
Identifying the contribution of mGluR activation to neuronal excitability in vivo will be a crucial step for ultimately establishing the importance of this mechanism for hippocampal function.
Positive_regulation (activation) of mGluR in neuronal associated with neuronal excitability
16) Confidence 0.10 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.12
Indeed, a number of reports implicate the activation of cation currents following group I mGluR activation in hippocampal neurons [34]–[39].
Positive_regulation (activation) of mGluR in neurons
17) Confidence 0.10 Published 2010 Journal PLoS Biology Section Body Doc Link PMC2982802 Disease Relevance 0.05 Pain Relevance 0.08
Effects of mGluR activation on subthreshold membrane potential changes are negligible but are large following action potential firing.
Positive_regulation (activation) of mGluR associated with action potential
18) Confidence 0.10 Published 2010 Journal PLoS Biology Section Abstract Doc Link PMC2982802 Disease Relevance 0 Pain Relevance 0.43
Excessive activation of mGluR5 has been associated with psychiatric, neurological and neurodegenerative diseases, including Parkinson's disease, anxiety, depression, schizophrenia, pain, epilepsy, focal and global ischemia diseases. 2-methyl-6-(phenylethynyl)pyridine (MPEP) and 2-methyl-4-(pyridin-3-ylethynyl)thiazole (MTEP) are the first generation of non-competitive mGluR5 antagonists with potent, selective and systemically active properties.
Positive_regulation (activation) of mGluR5 associated with pain, depression, ischemia, anxiety disorder, disease, schizophrenia, epilepsy, antagonist and neurodegenerative disease
19) Confidence 0.10 Published 2007 Journal Curr Top Med Chem Section Abstract Doc Link 17979788 Disease Relevance 0.91 Pain Relevance 0.64
Stimulation of mGluR5 leads to the release of calcium from intracellular supplies and protein kinase C activation.
Positive_regulation (Stimulation) of mGluR5 associated with kinase c
20) Confidence 0.10 Published 2007 Journal Curr Top Med Chem Section Abstract Doc Link 17979788 Disease Relevance 0.77 Pain Relevance 0.59

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