INT95790

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Context Info
Confidence 0.61
First Reported 2001
Last Reported 2011
Negated 7
Speculated 4
Reported most in Abstract
Documents 55
Total Number 59
Disease Relevance 21.17
Pain Relevance 16.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
brain 3
neurons 3
macrophages 2
sciatic nerve 2
spinal cord dorsal horn 2
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nav1.7 1 99.90 Very High Very High Very High
Spinal cord 77 99.84 Very High Very High Very High
Kinase C 61 99.76 Very High Very High Very High
sodium channel 23 99.76 Very High Very High Very High
Ventral tegmentum 67 99.68 Very High Very High Very High
Sciatic nerve 56 99.68 Very High Very High Very High
Glutamate receptor 26 99.68 Very High Very High Very High
Morphine 92 99.66 Very High Very High Very High
Dorsal horn neuron 29 99.44 Very High Very High Very High
cocaine 254 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 193 100.00 Very High Very High Very High
Congenital Anomalies 12 100.00 Very High Very High Very High
Nociception 45 99.36 Very High Very High Very High
Neuropathic Pain 95 99.18 Very High Very High Very High
Apoptosis 169 99.12 Very High Very High Very High
Chronic Myeloid Leukemia 33 98.88 Very High Very High Very High
Hyperplasia 22 98.80 Very High Very High Very High
Endometriosis 17 98.76 Very High Very High Very High
INFLAMMATION 214 98.64 Very High Very High Very High
Depression 49 98.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was designed to determine whether chronic morphine treatment could influence the activity of extracellular signal regulated kinase (ERK) in the mouse brain.
Regulation (influence) of ERK in brain associated with morphine
1) Confidence 0.61 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11988336 Disease Relevance 0 Pain Relevance 1.00
In hyperactive mice psychostimulant-mediated behavioral inhibition and ERK regulation are also mimicked by the serotonergic drugs fluoxetine and 5-carboxamidotryptamine, thereby revealing the involvement of serotonin-dependent inhibition of striatal ERK signaling.
Regulation (regulation) of ERK associated with serotonin and fluoxetine
2) Confidence 0.60 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16954211 Disease Relevance 0.61 Pain Relevance 0.46
In the present studies, we sought to test the hypothesis that group I mGluRs modulate nociceptive transmission or plasticity via modulation of ERK signaling in dorsal horn neurons.
Regulation (modulation) of ERK in neurons associated with nociception and dorsal horn neuron
3) Confidence 0.45 Published 2001 Journal J. Neurosci. Section Abstract Doc Link 11356865 Disease Relevance 0.60 Pain Relevance 0.70
Role of the ERK pathway in spontaneous and acute D-amph- and cocaine-induced hyperlocomotion
Regulation (Role) of ERK associated with cocaine
4) Confidence 0.44 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.24
Role of the ERK pathway in the development of locomotor sensitization induced by D-amph
Regulation (Role) of ERK
5) Confidence 0.44 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0.12 Pain Relevance 0.18
In contrast, when the animals were already sensitized by D-amph, ERK blockade did not affect the expression of sensitized response.


Neg (not) Regulation (affect) of ERK
6) Confidence 0.44 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.27
Role of different brain regions in ERK-dependent behavioral sensitization
Regulation (Role) of ERK in brain
7) Confidence 0.44 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1420315 Disease Relevance 0 Pain Relevance 0.25
The extracellular signal-regulated kinase (Erk) cascades are suggested to contribute to excitatory synaptic plasticity in the CNS, including the spinal cord dorsal horn.
Regulation (contribute) of Erk in spinal cord dorsal horn associated with dorsal horn and spinal cord
8) Confidence 0.42 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16421305 Disease Relevance 0.12 Pain Relevance 0.46
The extracellular signal-regulated kinase (Erk) cascades are suggested to contribute to excitatory synaptic plasticity in the CNS, including the spinal cord dorsal horn.
Regulation (contribute) of extracellular signal-regulated kinase in spinal cord dorsal horn associated with dorsal horn and spinal cord
9) Confidence 0.42 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 16421305 Disease Relevance 0.12 Pain Relevance 0.46
However, these pharmacological studies have not been able to determine the specific role of the two predominant isoforms of ERK (ERK1 and ERK2) in these processes.
Spec (determine) Regulation (role) of ERK2
10) Confidence 0.42 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16407894 Disease Relevance 0.07 Pain Relevance 0.35
However, these pharmacological studies have not been able to determine the specific role of the two predominant isoforms of ERK (ERK1 and ERK2) in these processes.
Spec (determine) Regulation (role) of ERK
11) Confidence 0.42 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16407894 Disease Relevance 0.07 Pain Relevance 0.35
The purpose of our study was to investigate the role of the ERK pathway in the development of endometriosis and to test the effects of protein kinase inhibitors on the proliferation of endometriotic cells in vitro and in vivo.
Spec (investigate) Regulation (role) of ERK associated with endometriosis
12) Confidence 0.41 Published 2010 Journal J. Pathol. Section Abstract Doc Link 20821752 Disease Relevance 0.90 Pain Relevance 0.29
In the present study, we investigated whether a state of neuropathic pain induced by sciatic nerve ligation could change the activities of the extracellular signal-regulated kinase (ERK) and p38 in the mouse lower midbrain area including the ventral tegmental area (VTA), and these changes could directly affect the development of the morphine-induced rewarding effect in mice.
Regulation (change) of ERK in sciatic nerve associated with ventral tegmentum, neuropathic pain, midbrain, sciatic nerve and morphine
13) Confidence 0.40 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15009639 Disease Relevance 0.34 Pain Relevance 1.02
Role of extracellular signal-regulated kinase in the ventral tegmental area in the suppression of the morphine-induced rewarding effect in mice with sciatic nerve ligation.
Regulation (Role) of extracellular signal-regulated kinase in ventral associated with ventral tegmentum, sciatic nerve and morphine
14) Confidence 0.40 Published 2004 Journal J. Neurochem. Section Title Doc Link 15009639 Disease Relevance 0.31 Pain Relevance 1.04
In the present study, we investigated whether a state of neuropathic pain induced by sciatic nerve ligation could change the activities of the extracellular signal-regulated kinase (ERK) and p38 in the mouse lower midbrain area including the ventral tegmental area (VTA), and these changes could directly affect the development of the morphine-induced rewarding effect in mice.
Regulation (change) of extracellular signal-regulated kinase in sciatic nerve associated with ventral tegmentum, neuropathic pain, midbrain, sciatic nerve and morphine
15) Confidence 0.40 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 15009639 Disease Relevance 0.34 Pain Relevance 1.00
The changes in ERK and Akt phosphorylation levels were also observed in white adipose tissues of UCP1-knockout mice fed the evodiamine diet.
Regulation (changes) of ERK in adipose tissues associated with targeted disruption
16) Confidence 0.39 Published 2008 Journal Endocrinology Section Abstract Doc Link 17884939 Disease Relevance 0.38 Pain Relevance 0.13
Our present data provide the first evidence that Ng is involved in the regulation of ERK activity and neuronal skeleton network, suggesting its important role in neuron growth and differentiation.



Regulation (regulation) of ERK in neuron
17) Confidence 0.37 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.18 Pain Relevance 0.10
Thus, altogether these data support a role of Hcy on ERK activation, via complex mechanisms, starting with a control of glutamate release, which in turn activates ionotropic and metabotropic receptor subtypes and produces increases in intracellular calcium levels.
Regulation (role) of ERK associated with glutamate
18) Confidence 0.37 Published 2005 Journal Neuroscience Section Abstract Doc Link 15916860 Disease Relevance 0.18 Pain Relevance 0.29
is modulated, in addition to ligand binding, by phosphorylation of a serine residue by MAPKs, such as extracellular signal-regulated protein kinases-1/2 (ERK-1/2), or by nucleocytoplasmic compartmentalization through the ERK activators MAPK kinases-1/2 (MEK-1/2).
Regulation (regulated) of ERK
19) Confidence 0.35 Published 2008 Journal PPAR Research Section Abstract Doc Link PMC2440494 Disease Relevance 0.66 Pain Relevance 0.04
Then we tested the effects of JNK or p38 inhibitor on the induction of cingulate LTP, because the MAPK signaling pathways include extracellular signal-regulated (ERK), c-Jun N-terminal kinase (JNK), p38 and ERK5 [17].
Regulation (regulated) of ERK associated with long-term potentiation
20) Confidence 0.35 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.29

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